faculty

Robert Bradley

rbradley@fredhutch.org

Fred Hutch, 

Biophysical and Structural Biology

Cancer Biology

Genetics, Genomics & Evolution

RNA in human disease

Faculty Contact Information

Building: Arnold Building Room: M1-B853 Box: M1-B514 Phone: 206-667-5662 http://bradleybiology.org/

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Weintraub Building Room: B3-111 Box: A3-015 Phone: 206-667-3193 http://bradleybiology.org/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia.

Wang E, Lu SX, Pastore A, Chen X, Imig J, Chun-Wei Lee S, Hockemeyer K, Ghebrechristos YE, Yoshimi A, Inoue D, Ki M, Cho H, Bitner L, Kloetgen A, Lin KT, Uehara T, Owa T, Tibes R, Krainer AR, Abdel-Wahab O, Aifantis I.

Cancer cell. 2019; 35(3):369-384.e7. NIHMSID: NIHMS1520966

PubMed [journal]
PMID:
30799057
PMCID:
PMC6424627

Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy.

Jagannathan S, Ogata Y, Gafken PR, Tapscott SJ, Bradley RK.

eLife. 2019; 8.

PubMed [journal]
PMID:
30644821
PMCID:
PMC6349399

Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing.

Blazquez L, Emmett W, Faraway R, Pineda JMB, Bajew S, Gohr A, Haberman N, Sibley CR, Bradley RK, Irimia M, Ule J.

Molecular cell. 2018; 72(3):496-509.e9.

PubMed [journal]
PMID:
30388411
PMCID:
PMC6224609

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1.

Fei DL, Zhen T, Durham B, Ferrarone J, Zhang T, Garrett L, Yoshimi A, Abdel-Wahab O, Bradley RK, Liu P, Varmus H.

Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(44):E10437-E10446.

PubMed [journal]
PMID:
30322915
PMCID:
PMC6217397

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.

Lee SC, North K, Kim E, Jang E, Obeng E, Lu SX, Liu B, Inoue D, Yoshimi A, Ki M, Yeo M, Zhang XJ, Kim MK, Cho H, Chung YR, Taylor J, Durham BH, Kim YJ, Pastore A, Monette S, Palacino J, Seiler M, Buonamici S, Smith PG, Ebert BL, Bradley RK, Abdel-Wahab O.

Cancer cell. 2018; 34(2):225-241.e8. NIHMSID: NIHMS989816

PubMed [journal]
PMID:
30107174
PMCID:
PMC6373472

Research Summary

We are interested in discovering new roles for RNA in human disease. We study all aspects of the RNA life cycle, from splicing to translation to degradation. Our broad goal is to uncover new biological phenomena that are relevant to the initiation, progression, or treatment of diseases such as leukemia and muscular dystrophy.