Jason Smith

Associate Professor

University of Washington


Microbiology, Infection & Immunity

Host/Pathogen Interactions in the Intestine

Faculty Contact Information

Building: South Lake Union Building F Room: F571 Box: 358070 Phone: 206-685-6144 https://microbiology.washington.edu/users/jason-g-smith

Research Summary

The Smith lab is primarily focused on host/pathogen interactions at mucosal surfaces. We use 3D intestinal enteroid culture methodology to examine sensing of and response to viruses and bacteria by intestinal epithelial cells. A major class of secreted host proteins that we study is a family of antimicrobial peptides called defensins, and we are investigating their role in viral infection and pathogenesis. We are also interested in the biology of intestinal Paneth cells and their role in Crohn’s disease.

DEI Statement

The Smith Lab values and is committed to a diverse, equitable, and inclusive environment in the lab, department, and school. We believe that the optimal environment to foster creativity and independence in the pursuit of knowledge is one in which everyone feels welcomed, respected, valued, and encouraged to perform to the best of their abilities.

Training Summary

Reimagining Mentoring (HHMI Gilliam, Dept. of Chemistry, UW PR2ISM, ISCRM) – April 2022

Empowering Prevention & Inclusive Communities (EPIC); Building Healthy Workplaces (Biomedical Research Programs) – September 2020

Reflecting on STEM Instructor Identity; Positionality and Privilege, Developing an Equitable STEM Curriculum; Understanding URM Undergraduate STEM Student Experiences (UW PR2ISM) – July-August 2020

Center for Improvement of Mentored Experiences in Research (CIMER) Training – November 2019

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PubMed Collection Link

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter

Lab Information

Location: University of Washington
Building: South Lake Union Building F
Room: F560
Box: 358070
Phone: 206-616-5649