Jason Smith


University of Washington, 

Developmental Biology, Stem Cells & Aging

Microbiology, Infection & Immunity

Host/Pathogen Interactions in the Intestine

Faculty Contact Information

Building: South Lake Union Building F Room: F571 Box: 358070 Phone: 206-685-6144 https://microbiology.washington.edu/users/jason-g-smith

Lab Information

Location: University of Washington Building: South Lake Union Building F Room: F560 Box: 358070 Phone: 206-616-5649 http://faculty.washington.edu/jgsmith2/Welcome.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter

Research Summary

The Smith lab is primarily focused on host/pathogen interactions at mucosal surfaces. We use 3D intestinal enteroid culture methodology to examine sensing of viruses and bacteria by host cells and to study the development, cell biology, and secretion mechanisms of intestinal epithelial cells. A major class of secreted host proteins that we study is a family of antimicrobial peptides called defensins, and we are interested in their role in viral infection and pathogenesis. We are also interested in the biology of intestinal Paneth cells and their role in Crohn’s disease.