Daniel Promislow
promislo@uw.eduUniversity of Washington,
Developmental Biology, Stem Cells & Aging
Genetics, Genomics & Evolution
Neuroscience
Evolutionary and quantitative genetics of aging and reproduction
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
Recent Advances in the Systems Biology of Aging.
McCormick MA, Promislow DEL.
Antioxidants & redox signaling. 2018; 29(10):973-984.
- PMID:
- 29020802
- PMCID:
- PMC6104255
Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.
Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM.
Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(38):9586-9591.
- PMID:
- 30185560
- PMCID:
- PMC6156608
Derous D, Mitchell SE, Green CL, Wang Y, Han JDJ, Chen L, Promislow DEL, Lusseau D, Douglas A, Speakman JR.
The journals of gerontology. Series A, Biological sciences and medical sciences. 2018; 73(3):279-288.
- PMID:
- 28575190
- PMCID:
- PMC5861923
Tissue-specific insulin signaling mediates female sexual attractiveness.
Fedina TY, Arbuthnott D, Rundle HD, Promislow DEL, Pletcher SD.
PLoS genetics. 2017; 13(8):e1006935.
- PMID:
- 28817572
- PMCID:
- PMC5560536
Derous D, Mitchell SE, Wang L, Green CL, Wang Y, Chen L, Han JJ, Promislow DEL, Lusseau D, Douglas A, Speakman JR.
Aging. 2017; 9(7):1770-1824.
- PMID:
- 28768896
- PMCID:
- PMC5559174
Proteomics and metabolomics in ageing research: from biomarkers to systems biology.
Hoffman JM, Lyu Y, Pletcher SD, Promislow DEL.
Essays in biochemistry. 2017; 61(3):379-388. NIHMSID: NIHMS929265
- PMID:
- 28698311
- PMCID:
- PMC5743054
Green CL, Mitchell SE, Derous D, Wang Y, Chen L, Han JJ, Promislow DEL, Lusseau D, Douglas A, Speakman JR.
Aging cell. 2017; 16(3):529-540.
- PMID:
- 28139067
- PMCID:
- PMC5418186
Perceptive costs of reproduction drive ageing and physiology in male Drosophila.
Harvanek ZM, Lyu Y, Gendron CM, Johnson JC, Kondo S, Promislow DEL, Pletcher SD.
Nature ecology & evolution. 2017; 1(6):152. NIHMSID: NIHMS862756
- PMID:
- 28812624
- PMCID:
- PMC5657004
Urfer SR, Kaeberlein TL, Mailheau S, Bergman PJ, Creevy KE, Promislow DEL, Kaeberlein M.
GeroScience. 2017; 39(2):117-127.
- PMID:
- 28374166
- PMCID:
- PMC5411365
Mitchell SE, Tang Z, Kerbois C, Delville C, Derous D, Green CL, Wang Y, Han JJ, Chen L, Douglas A, Lusseau D, Promislow DE, Speakman JR.
Oncotarget. 2017; 8(11):17453-17474.
- PMID:
- 28193912
- PMCID:
- PMC5392262
Research Summary
My research is focused on trying to understand the basic forces that shape fitness traits in natural populations. I also use a systems biology approach to probe the mechanisms by which genotypes shape phenotypes. The evolution of aging serves as a conceptual focus for much of our work, but the lab is equally marked by the diversity of interests of the students and post-docs, including neurodegenerative disease, sexual selection, and epigenetics. While most lab studies are on flies, I also run a large national long-term study on the systems biology of aging in dogs.