Daniel Promislow
promislo@uw.eduUniversity of Washington,
Developmental Biology, Stem Cells & Aging
Genetics, Genomics & Evolution
Neuroscience
Evolutionary and quantitative genetics of aging and reproduction
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
Lee MB, Dowsett IT, Carr DT, Wasko BM, Stanton SG, Chung MS, Ghodsian N, Bode A, Kiflezghi MG, Uppal PA, Grayden KA, Elala YC, Tang TT, Tran NHB, Tran THB, Diep AB, Hope M, Promislow DEL, Kennedy SR, Kaeberlein M, Herr AJ.
Proceedings of the National Academy of Sciences of the United States of America. 2019; 116(8):3062-3071.
- PMID:
- 30718408
- PMCID:
- PMC6386679
The metabolome as a biomarker of mortality risk in the common marmoset.
Hoffman JM, Ross C, Tran V, Promislow DEL, Tardif S, Jones DP.
American journal of primatology. 2019; 81(2):e22944.
- PMID:
- 30585652
Green CL, Soltow QA, Mitchell SE, Derous D, Wang Y, Chen L, Han JJ, Promislow DEL, Lusseau D, Douglas A, Jones DP, Speakman JR.
The journals of gerontology. Series A, Biological sciences and medical sciences. 2019; 74(1):16-26.
- PMID:
- 29718123
- PMCID:
- PMC6298180
Hoffman JM, Lourenço BN, Promislow DEL, Creevy KE.
The Journal of small animal practice. 2018; 59(11):681-690.
- PMID:
- 30039567
Tudor E, Promislow DEL, Arbuthnott D.
Behavioral ecology : official journal of the International Society for Behavioral Ecology. 2018; 29(6):1409-1414.
- PMID:
- 30568395
- PMCID:
- PMC6293226
Ederer KA, Jin K, Bouslog S, Wang L, Gorman GS, Rowe GC, Abadir P, Raftery D, Moellering D, Promislow D, Jumbo-Lucioni P, De Luca M.
International journal of molecular sciences. 2018; 19(11).
- PMID:
- 30373167
- PMCID:
- PMC6274988
Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans.
Walters RO, Arias E, Diaz A, Burgos ES, Guan F, Tiano S, Mao K, Green CL, Qiu Y, Shah H, Wang D, Hudgins AD, Tabrizian T, Tosti V, Shechter D, Fontana L, Kurland IJ, Barzilai N, Cuervo AM, Promislow DEL, Huffman DM.
Cell reports. 2018; 25(3):663-676.e6. NIHMSID: NIHMS1510879
- PMID:
- 30332646
- PMCID:
- PMC6280974
Research to Promote Longevity and Health Span in Companion Dogs: A Pediatric Perspective.
Wilfond BS, Porter KM, Creevy KE, Kaeberlein M, Promislow D.
The American journal of bioethics : AJOB. 2018; 18(10):64-65. NIHMSID: NIHMS1514902
- PMID:
- 30339074
- PMCID:
- PMC6317354
Recent Advances in the Systems Biology of Aging.
McCormick MA, Promislow DEL.
Antioxidants & redox signaling. 2018; 29(10):973-984.
- PMID:
- 29020802
- PMCID:
- PMC6104255
Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.
Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM.
Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(38):9586-9591.
- PMID:
- 30185560
- PMCID:
- PMC6156608
Research Summary
My research is focused on trying to understand the basic forces that shape fitness traits in natural populations. I also use a systems biology approach to probe the mechanisms by which genotypes shape phenotypes. The evolution of aging serves as a conceptual focus for much of our work, but the lab is equally marked by the diversity of interests of the students and post-docs, including neurodegenerative disease, sexual selection, and epigenetics. While most lab studies are on flies, I also run an NIH-funded nationwide study on the systems biology of aging in pet dogs (dogagingproject.com).