Rachel Klevit
klevit@uw.eduUniversity of Washington,
Biophysical and Structural Biology
Structural biology and biochemistry of human proteins
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
DaRosa PA, Harrison JS, Zelter A, Davis TN, Brzovic P, Kuhlman B, Klevit RE.
Molecular cell. 2018; 72(4):753-765.e6. NIHMSID: NIHMS1507957
- PMID:
- 30392931
- PMCID:
- PMC6239910
Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs.
DaRosa PA, Klevit RE, Xu W.
Protein science : a publication of the Protein Society. 2018; 27(6):1057-1067.
- PMID:
- 29604130
- PMCID:
- PMC5980575
Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector.
Akturk A, Wasilko DJ, Wu X, Liu Y, Zhang Y, Qiu J, Luo ZQ, Reiter KH, Brzovic PS, Klevit RE, Mao Y.
Nature. 2018; 557(7707):729-733. NIHMSID: NIHMS961338
- PMID:
- 29795346
- PMCID:
- PMC5980775
Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex.
Tuttle LM, Pacheco D, Warfield L, Luo J, Ranish J, Hahn S, Klevit RE.
Cell reports. 2018; 22(12):3251-3264. NIHMSID: NIHMS955389
- PMID:
- 29562181
- PMCID:
- PMC5908246
Baughman HER, Clouser AF, Klevit RE, Nath A.
The Journal of biological chemistry. 2018; 293(8):2687-2700.
- PMID:
- 29298892
- PMCID:
- PMC5827454
De novo mutation in RING1 with epigenetic effects on neurodevelopment.
Pierce SB, Stewart MD, Gulsuner S, Walsh T, Dhall A, McClellan JM, Klevit RE, King MC.
Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(7):1558-1563.
- PMID:
- 29386386
- PMCID:
- PMC5816211
Wilburn DB, Tuttle LM, Klevit RE, Swanson WJ.
Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(6):1310-1315.
- PMID:
- 29348201
- PMCID:
- PMC5819389
Stewart MD, Zelin E, Dhall A, Walsh T, Upadhyay E, Corn JE, Chatterjee C, King MC, Klevit RE.
Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(6):1316-1321.
- PMID:
- 29367421
- PMCID:
- PMC5819413
RING-Between-RING E3 Ligases: Emerging Themes amid the Variations.
Dove KK, Klevit RE.
Journal of molecular biology. 2017; 429(22):3363-3375. NIHMSID: NIHMS900838
- PMID:
- 28827147
- PMCID:
- PMC5675740
Dove KK, Kemp HA, Di Bona KR, Reiter KH, Milburn LJ, Camacho D, Fay DS, Miller DL, Klevit RE.
Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(32):E6576-E6584.
- PMID:
- 28739890
- PMCID:
- PMC5559030
Research Summary
We are interested in understanding the structural and chemical principles underlie important cellular processes, especially protein ubiquitylation and cellular response to stress. We are studying the enzyme responsible for protein ubiquitylation, which regulates virtually every cellular process. We are currently investigating ubiquitin E3 ligases such as BRCA1/BARD1 and HHARI, among others, with a goal towards understanding how they work and what the cellular outcomes are of their function and dysfunction. We also study the human small heat shock proteins (sHSPs), HSPB1 and HSPB5. These are th