faculty

Rachel Klevit

klevit@uw.edu

University of Washington, 

Biophysical and Structural Biology

Structural biology and biochemistry of human proteins

Faculty Contact Information

Building: HSB K-Wing Room: K-466 Box: 357350 Phone: 206-543-5891 http://depts.washington.edu/labklvt/

Lab Information

Location: University of Washington Building: HSB K-wing Phone: 206-543-6391 http://depts.washington.edu/labklvt/

Accepting Students For:

Rotation, Spring
Permanent

Publications

A Bifunctional Role for the UHRF1 UBL Domain in the Control of Hemi-methylated DNA-Dependent Histone Ubiquitylation.

DaRosa PA, Harrison JS, Zelter A, Davis TN, Brzovic P, Kuhlman B, Klevit RE.

Molecular cell. 2018; 72(4):753-765.e6. NIHMSID: NIHMS1507957

PubMed [journal]
PMID:
30392931
PMCID:
PMC6239910

Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs.

DaRosa PA, Klevit RE, Xu W.

Protein science : a publication of the Protein Society. 2018; 27(6):1057-1067.

PubMed [journal]
PMID:
29604130
PMCID:
PMC5980575

Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector.

Akturk A, Wasilko DJ, Wu X, Liu Y, Zhang Y, Qiu J, Luo ZQ, Reiter KH, Brzovic PS, Klevit RE, Mao Y.

Nature. 2018; 557(7707):729-733. NIHMSID: NIHMS961338

PubMed [journal]
PMID:
29795346
PMCID:
PMC5980775

Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex.

Tuttle LM, Pacheco D, Warfield L, Luo J, Ranish J, Hahn S, Klevit RE.

Cell reports. 2018; 22(12):3251-3264. NIHMSID: NIHMS955389

PubMed [journal]
PMID:
29562181
PMCID:
PMC5908246

HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation.

Baughman HER, Clouser AF, Klevit RE, Nath A.

The Journal of biological chemistry. 2018; 293(8):2687-2700.

PubMed [journal]
PMID:
29298892
PMCID:
PMC5827454

Research Summary

We are interested in understanding the structural and chemical principles underlie important cellular processes, especially protein ubiquitylation and cellular response to stress. We are studying the enzyme responsible for protein ubiquitylation, which regulates virtually every cellular process. We are currently investigating ubiquitin E3 ligases such as BRCA1/BARD1 and HHARI, among others, with a goal towards understanding how they work and what the cellular outcomes are of their function and dysfunction. We also study the human small heat shock proteins (sHSPs), HSPB1 and HSPB5. These are th