Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
Cancer Genetics, Mouse Models
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Our lab is focused on understanding mechanisms through which cancer-mutated genes drive tumorigenesis. We study small cell lung cancer (SCLC), an aggressive neuroendocrine tumor type. We perform genomic analyses to identify and understand genes that contribute to tumor initiation, progression and therapy response. Our research make extensive use of genetically engineered mouse and patient-derived xenograft (PDX) models of SCLC. These studies are complemented with functional CRISPR inactivation and cDNA overexpression screens performed in SCLC cells and in vivo.