Seattle Childrens Research Institute,
Biophysical and Structural Biology
Cancer Biology (Area Director)
Cell Signaling & Cell/Environment Interactions
Cell Adhesion in Morphogenesis and Disease
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We study the molecular processes controlling tissue architecture and morphogenesis, which are important for tissue development, regeneration, physiology, and tumor metastasis. We study the structural and biochemical mechanisms underlying regulation of cadherin adhesion at the cell surface as well as how cadherin regulation controls cell junctions during physiological processes. These include epithelial and endothelial barrier function in inflammation, and tumor metastasis. We also study how cadherins signal to control growth and differentiation through the Wnt-ß-catenin and Hippo pathways.