faculty

Barry Gumbiner

gumbiner@uw.edu

Seattle Childrens Research Institute, 

Biophysical and Structural Biology

Cancer Biology (Area Director)

Cell Signaling & Cell/Environment Interactions

Cell Adhesion in Morphogenesis and Disease

Faculty Contact Information

Building: Jack MacDonald Bldg Room: JMB 523 Box: JMB-5 Phone: 206-884-5116 http://www.seattlechildrens.org/research/developmental-biology-regenerative-medicine/gumbiner-lab/

Lab Information

Location: Seattle Childrens Research Institute Building: Jack MacDonald Building Room: JMB 523 Box: JMB-5 Phone: 206-884-5116 http://www.seattlechildrens.org/research/developmental-biology-regenerative-medicine/gumbiner-lab/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

E-cadherin in contact inhibition and cancer.

Mendonsa AM, Na TY, Gumbiner BM.

Oncogene. 2018 Aug; 35(37)4769-4780

Roles for E-cadherin cell surface regulation in cancer.

Petrova YI, Schecterson L, Gumbiner BM.

Mol Biol Cell. 2016 Nov 1; 21(27)3233-3244

Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.

Kim NG, Gumbiner BM.

J Cell Biol. 2015 Aug 3; 3(210)503-15

Research Summary

We study the molecular processes controlling tissue architecture and morphogenesis, which are important for tissue development, regeneration, physiology, and tumor metastasis. We study the structural and biochemical mechanisms underlying regulation of cadherin adhesion at the cell surface as well as how cadherin regulation controls cell junctions during physiological processes. These include epithelial and endothelial barrier function in inflammation, and tumor metastasis. We also study how cadherins signal to control growth and differentiation through the Wnt-ß-catenin and Hippo pathways.