Seattle Childrens Research Institute,
Biophysical and Structural Biology
Cancer Biology (Area Director)
Cell Signaling & Cell/Environment Interactions
Cell Adhesion in Morphogenesis and Disease
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We are interested in tissue architecture and morphogenesis, which is important for the development of embryos and organs, the maintenance and regeneration of tissues, and the control of diseases, such as cancer and inflammation. We study how cadherin adhesive function at the cell surface is regulated to control cell-cell junctions during morphogenesis, tumor metastasis, and epithelial and endothelial barrier function and inflammation. We also study how cell contacts and cadherins signal into the cell to control growth and differentiation through the Wnt-ß-catenin and Hippo signaling pathways.