Barry Gumbiner
gumbiner@uw.eduSeattle Childrens Research Institute,
Biophysical and Structural Biology
Cancer Biology (Area Director)
Cell Signaling & Cell/Environment Interactions
Cell Adhesion in Morphogenesis and Disease
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
The following publications were retrieved from PubMed:
E-cadherin in contact inhibition and cancer.
Mendonsa AM, Na TY, Gumbiner BM.
Oncogene. 2018 Aug; 35(37)4769-4780
Roles for E-cadherin cell surface regulation in cancer.
Petrova YI, Schecterson L, Gumbiner BM.
Mol Biol Cell. 2016 Nov 1; 21(27)3233-3244
Deregulation of the Hippo pathway in mouse mammary stem cells promotes mammary tumorigenesis.
Li H, Gumbiner BM.
Mamm Genome. 2016 Dec; 11-12(27)556-564
Maiden SL, Petrova YI, Gumbiner BM.
PLoS One. 2016; 2(11)e0148574
Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.
Kim NG, Gumbiner BM.
J Cell Biol. 2015 Aug 3; 3(210)503-15
Allosteric Regulation of E-Cadherin Adhesion.
Shashikanth N, Petrova YI, Park S, Chekan J, Maiden S, Spano M, Ha T, Gumbiner BM, Leckband DE.
J Biol Chem. 2015 Aug 28; 35(290)21749-61
Cadherin-6B is required for the generation of Islet-1-expressing dorsal interneurons.
Park KS, Gumbiner BM.
Biochem Biophys Res Commun. 2015 Apr 10; 3(459)504-8
Park KS, Dubon MJ, Gumbiner BM.
Tumour Biol. 2015 May; 5(36)3549-56
The Hippo-YAP signaling pathway and contact inhibition of growth.
Gumbiner BM, Kim NG.
J Cell Sci. 2014 Feb 15; Pt 4(127)709-17
Fan R, Kim NG, Gumbiner BM.
Proc Natl Acad Sci U S A. 2013 Feb 12; 7(110)2569-74
Park KS, Gumbiner BM.
Dev Biol. 2012 Jun 15; 2(366)232-43
Petrova YI, Spano MM, Gumbiner BM.
Mol Biol Cell. 2012 Jun; 11(23)2092-108
p53 and microRNA-34 are suppressors of canonical Wnt signaling.
Kim NH, Kim HS, Kim NG, Lee I, Choi HS, Li XY, Kang SE, Cha SY, Ryu JK, Na JM, Park C, Kim K, Lee S, Gumbiner BM, Yook JI, Weiss SJ.
Sci Signal. 2011 Nov 1; 197(4)ra71
Axial protocadherin (AXPC) regulates cell fate during notochordal morphogenesis.
Yoder MD, Gumbiner BM.
Dev Dyn. 2011 Nov; 11(240)2495-504
E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.
Kim NG, Koh E, Chen X, Gumbiner BM.
Proc Natl Acad Sci U S A. 2011 Jul 19; 29(108)11930-5
Park KS, Gumbiner BM.
Development. 2010 Aug; 16(137)2691-701
A protocadherin-cadherin-FLRT3 complex controls cell adhesion and morphogenesis.
Chen X, Koh E, Yoder M, Gumbiner BM.
PLoS One. 2009 Dec 22; 12(4)e8411
Regulation of protein stability by GSK3 mediated phosphorylation.
Xu C, Kim NG, Gumbiner BM.
Cell Cycle. 2009 Dec 15; 24(8)4032-9
Identification of targets of the Wnt pathway destruction complex in addition to beta-catenin.
Kim NG, Xu C, Gumbiner BM.
Proc Natl Acad Sci U S A. 2009 Mar 31; 13(106)5165-70
Convergence and extension at gastrulation require a myosin IIB-dependent cortical actin network.
Skoglund P, Rolo A, Chen X, Gumbiner BM, Keller R.
Development. 2008 Aug; 14(135)2435-44
Vonica A, Gumbiner BM.
Dev Biol. 2007 Dec 1; 1(312)90-102
Chen X, Molino C, Liu L, Gumbiner BM.
J Biol Chem. 2007 Nov 2; 44(282)32128-37
Perrais M, Chen X, Perez-Moreno M, Gumbiner BM.
Mol Biol Cell. 2007 Jun; 6(18)2013-25
Cadherin conformations associated with dimerization and adhesion.
Tsuiji H, Xu L, Schwartz K, Gumbiner BM.
J Biol Chem. 2007 Apr 27; 17(282)12871-82
Characterization of a 60S complex of the adenomatous polyposis coli tumor suppressor protein.
Mahadevaiyer S, Xu C, Gumbiner BM.
Biochim Biophys Acta. 2007 Feb; 2(1773)120-30
Crosstalk between different adhesion molecules.
Chen X, Gumbiner BM.
Curr Opin Cell Biol. 2006 Oct; 5(18)572-8
Chen X, Gumbiner BM.
J Cell Biol. 2006 Jul 17; 2(174)301-13
Qin Y, Capaldo C, Gumbiner BM, Macara IG.
J Cell Biol. 2005 Dec 19; 6(171)1061-71
Regulation of cadherin-mediated adhesion in morphogenesis.
Gumbiner BM
Nat Rev Mol Cell Biol. 2005 Aug; 8(6)622-34
Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes.
Gottardi CJ, Gumbiner BM.
J Cell Biol. 2004 Oct 25; 2(167)339-49
Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions.
Gottardi CJ, Gumbiner BM.
Am J Physiol Cell Physiol. 2004 Apr; 4(286)C747-56
Suh EK, Gumbiner BM.
Exp Cell Res. 2003 Nov 1; 2(290)447-56
Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin.
Wong AS, Gumbiner BM.
J Cell Biol. 2003 Jun 23; 6(161)1191-203
Functional analysis of the structural basis of homophilic cadherin adhesion.
Zhu B, Chappuis-Flament S, Wong E, Jensen IE, Gumbiner BM, Leckband D.
Biophys J. 2003 Jun; 6(84)4033-42
Huen AC, Park JK, Godsel LM, Chen X, Bannon LJ, Amargo EV, Hudson TY, Mongiu AK, Leigh IM, Kelsell DP, Gumbiner BM, Green KJ.
J Cell Biol. 2002 Dec 23; 6(159)1005-17
Zygotic Wnt activity is required for Brachyury expression in the early Xenopus laevis embryo.
Vonica A, Gumbiner BM.
Dev Biol. 2002 Oct 1; 1(250)112-27
C-cadherin ectodomain structure and implications for cell adhesion mechanisms.
Boggon TJ, Murray J, Chappuis-Flament S, Wong E, Gumbiner BM, Shapiro L.
Science. 2002 May 17; 5571(296)1308-13
Cadherin-mediated cell sorting not determined by binding or adhesion specificity.
Niessen CM, Gumbiner BM.
J Cell Biol. 2002 Jan 21; 2(156)389-399
Adhesion signaling: how beta-catenin interacts with its partners.
Gottardi CJ, Gumbiner BM.
Curr Biol. 2001 Oct 2; 19(11)R792-4
Cadherin engagement regulates Rho family GTPases.
Noren NK, Niessen CM, Gumbiner BM, Burridge K.
J Biol Chem. 2001 Sep 7; 36(276)33305-8
Multiple cadherin extracellular repeats mediate homophilic binding and adhesion.
Chappuis-Flament S, Wong E, Hicks LD, Kay CM, Gumbiner BM.
J Cell Biol. 2001 Jul 9; 1(154)231-43
Gottardi CJ, Wong E, Gumbiner BM.
J Cell Biol. 2001 May 28; 5(153)1049-60
Sivasankar S, Gumbiner B, Leckband D.
Biophys J. 2001 Apr; 4(80)1758-68
Reinacher-Schick A, Gumbiner BM.
J Cell Biol. 2001 Feb 5; 3(152)491-502
Guger KA, Gumbiner BM.
Dev Biol. 2000 Jul 15; 2(223)441-8
Vonica A, Weng W, Gumbiner BM, Venuti JM.
Dev Biol. 2000 Jan 15; 2(217)230-43
Nelson RW, Gumbiner BM.
J Cell Biol. 1999 Oct 18; 2(147)367-74
Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains.
Sivasankar S, Brieher W, Lavrik N, Gumbiner B, Leckband D.
Proc Natl Acad Sci U S A. 1999 Oct 12; 21(96)11820-4
Lecuit M, Dramsi S, Gottardi C, Fedor-Chaiken M, Gumbiner B, Cossart P.
EMBO J. 1999 Jul 15; 14(18)3956-63
Analysis of C-cadherin regulation during tissue morphogenesis with an activating antibody.
Zhong Y, Brieher WM, Gumbiner BM.
J Cell Biol. 1999 Jan 25; 2(144)351-9
Nelson RW, Gumbiner BM.
Ann N Y Acad Sci. 1998 Oct 23; (857)86-98
Yap AS, Niessen CM, Gumbiner BM.
J Cell Biol. 1998 May 4; 3(141)779-89
Fagotto F, Glück U, Gumbiner BM.
Curr Biol. 1998 Feb 12; 4(8)181-90
Sehgal RN, Gumbiner BM, Reichardt LF.
J Cell Biol. 1997 Nov 17; 4(139)1033-46
Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, Perry WL 3rd, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F.
Cell. 1997 Jul 11; 1(90)181-92
Carcinogenesis: a balance between beta-catenin and APC.
Gumbiner BM
Curr Biol. 1997 Jul 1; 7(7)R443-6
Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function.
Yap AS, Brieher WM, Pruschy M, Gumbiner BM.
Curr Biol. 1997 May 1; 5(7)308-15
Vleminckx K, Wong E, Guger K, Rubinfeld B, Polakis P, Gumbiner BM.
J Cell Biol. 1997 Jan 27; 2(136)411-20
Wong V, Gumbiner BM.
J Cell Biol. 1997 Jan 27; 2(136)399-409
Molecular and functional analysis of cadherin-based adherens junctions.
Yap AS, Brieher WM, Gumbiner BM.
Annu Rev Cell Dev Biol. 1997; (13)119-46
Fagotto F, Guger K, Gumbiner BM.
Development. 1997 Jan; 2(124)453-60
Lateral dimerization is required for the homophilic binding activity of C-cadherin.
Brieher WM, Yap AS, Gumbiner BM.
J Cell Biol. 1996 Oct; 2(135)487-96
Desmosomal cadherin binding domains of plakoglobin.
Witcher LL, Collins R, Puttagunta S, Mechanic SE, Munson M, Gumbiner B, Cowin P.
J Biol Chem. 1996 May 3; 18(271)10904-9
Fagotto F, Funayama N, Gluck U, Gumbiner BM.
J Cell Biol. 1996 Mar; 6(132)1105-14
Cell adhesion: the molecular basis of tissue architecture and morphogenesis.
Gumbiner BM
Cell. 1996 Feb 9; 3(84)345-57
Guger KA, Gumbiner BM.
Dev Biol. 1995 Nov; 1(172)115-25
Cell-to-cell contact and extracellular matrix.
Gumbiner BM, Yamada KM.
Curr Opin Cell Biol. 1995 Oct; 5(7)615-8
Disruption of gastrulation movements in Xenopus by a dominant-negative mutant for C-cadherin.
Lee CH, Gumbiner BM.
Dev Biol. 1995 Oct; 2(171)363-73
Cell-cell recognition. Zipping together a cell adhesion interface.
Patel DJ, Gumbiner BM.
Nature. 1995 Mar 23; 6520(374)306-7
Funayama N, Fagotto F, McCrea P, Gumbiner BM.
J Cell Biol. 1995 Mar; 5(128)959-68
Heasman J, Crawford A, Goldstone K, Garner-Hamrick P, Gumbiner B, McCrea P, Kintner C, Noro CY, Wylie C.
Cell. 1994 Dec 2; 5(79)791-803
Fagotto F, Gumbiner BM.
Development. 1994 Dec; 12(120)3667-79
Regulation of C-cadherin function during activin induced morphogenesis of Xenopus animal caps.
Brieher WM, Gumbiner BM.
J Cell Biol. 1994 Jul; 2(126)519-27
Selective disruption of E-cadherin function in early Xenopus embryos by a dominant negative mutant.
Levine E, Lee CH, Kintner C, Gumbiner BM.
Development. 1994 Apr; 4(120)901-9
Induction of a secondary body axis in Xenopus by antibodies to beta-catenin.
McCrea PD, Brieher WM, Gumbiner BM.
J Cell Biol. 1993 Oct; 2(123)477-84
Proteins associated with the cytoplasmic surface of adhesion molecules.
Gumbiner BM
Neuron. 1993 Oct; 4(11)551-64
Catenins as mediators of the cytoplasmic functions of cadherins.
Gumbiner BM, McCrea PD.
J Cell Sci Suppl. 1993; (17)155-8
Peifer M, McCrea PD, Green KJ, Wieschaus E, Gumbiner BM.
J Cell Biol. 1992 Aug; 3(118)681-91
A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin.
McCrea PD, Turck CW, Gumbiner B.
Science. 1991 Nov 29; 5036(254)1359-61
Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.
Gumbiner B, Lowenkopf T, Apatira D.
Proc Natl Acad Sci U S A. 1991 Apr 15; 8(88)3460-4
McCrea PD, Gumbiner BM.
J Biol Chem. 1991 Mar 5; 7(266)4514-20
The distribution of E-cadherin during Xenopus laevis development.
Levi G, Gumbiner B, Thiery JP.
Development. 1991 Jan; 1(111)159-69
Generation and maintenance of epithelial cell polarity.
Gumbiner B
Curr Opin Cell Biol. 1990 Oct; 5(2)881-7
Choi YS, Sehgal R, McCrea P, Gumbiner B.
J Cell Biol. 1990 May; 5(110)1575-82
Choi YS, Gumbiner B.
J Cell Biol. 1989 Jun; 6(108)2449-58
Gumbiner B, Stevenson B, Grimaldi A.
J Cell Biol. 1988 Oct; 4(107)1575-87
Penetration of Salmonella through a polarized Madin-Darby canine kidney epithelial cell monolayer.
Finlay BB, Gumbiner B, Falkow S.
J Cell Biol. 1988 Jul; 1(107)221-30
Cadherins: a family of Ca2+-dependent adhesion molecules.
Gumbiner B
Trends Biochem Sci. 1988 Mar; 3(13)75-6
Structure, biochemistry, and assembly of epithelial tight junctions.
Gumbiner B
Am J Physiol. 1987 Dec; 6 Pt 1(253)C749-58
The role of uvomorulin in the formation of epithelial occluding junctions.
Gumbiner B, Simons K.
Ciba Found Symp. 1987; (125)168-86
The tight junction does not allow lipid molecules to diffuse from one epithelial cell to the next.
van Meer G, Gumbiner B, Simons K.
Nature. 1986 Aug 14-20; 6080(322)639-41
Gumbiner B, Simons K.
J Cell Biol. 1986 Feb; 2(102)457-68
Moore HP, Gumbiner B, Kelly RB.
J Cell Biol. 1983 Sep; 3(97)810-7
Chloroquine diverts ACTH from a regulated to a constitutive secretory pathway in AtT-20 cells.
Moore HP, Gumbiner B, Kelly RB.
Nature. 1983 Mar 31-Apr 6; 5907(302)434-6
Gumbiner B, Kelly RB.
Cell. 1982 Jan; 1(28)51-9
Gumbiner B, Kelly RB.
Proc Natl Acad Sci U S A. 1981 Jan; 1(78)318-22
Research Summary
We study the molecular processes controlling tissue architecture and morphogenesis, which are important for tissue development, regeneration, physiology, and tumor metastasis. We study the structural and biochemical mechanisms underlying regulation of cadherin adhesion at the cell surface as well as how cadherin regulation controls cell junctions during physiological processes. These include epithelial and endothelial barrier function in inflammation, and tumor metastasis. We also study how cadherins signal to control growth and differentiation through the Wnt-ß-catenin and Hippo pathways.