faculty

Jihong Bai

jbai@fredhutch.org

Fred Hutch, 

Biophysical and Structural Biology

Cell Signaling & Cell/Environment Interactions

Neuroscience (Area Director)

Molecular and Cellular Basis for Neural Communication

Faculty Contact Information

Building: Weintraub Building Room: A3-161 Phone: 206-667-1281 Alt Phone: 206-667-5025 http://research.fhcrc.org/bai/en.html

Lab Information

Location: FredHutchinsonCancerResearch Center Building: Weintraub Building A2-185 Room: 1100 Fairview Ave. N Phone: 206-667-5025 Alt Phone: 2066675025

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

γ-Neurexin and Frizzled Mediate Parallel Synapse Assembly Pathways Antagonized by Receptor Endocytosis.

Kurshan PT, Merrill SA, Dong Y, Ding C, Hammarlund M, Bai J, Jorgensen EM, Shen K.

Neuron. 2018; 100(1):150-166.e4. NIHMSID: NIHMS1506285

PubMed [journal]
PMID:
30269993
PMCID:
PMC6181781

An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans.

Chew YL, Tanizawa Y, Cho Y, Zhao B, Yu AJ, Ardiel EL, Rabinowitch I, Bai J, Rankin CH, Lu H, Beets I, Schafer WR.

Neuron. 2018; 99(6):1233-1246.e6.

PubMed [journal]
PMID:
30146306
PMCID:
PMC6162336

Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis.

Poudel KR, Roh-Johnson M, Su A, Ho T, Mathsyaraja H, Anderson S, Grady WM, Moens CB, Conacci-Sorrell M, Eisenman RN, Bai J.

Developmental cell. 2018; 45(6):738-752.e6. NIHMSID: NIHMS974590

PubMed [journal]
PMID:
29920278
PMCID:
PMC6095642

The C-terminal of CASY-1/Calsyntenin regulates GABAergic synaptic transmission at the Caenorhabditis elegans neuromuscular junction.

Thapliyal S, Vasudevan A, Dong Y, Bai J, Koushika SP, Babu K.

PLoS genetics. 2018; 14(3):e1007263.

PubMed [journal]
PMID:
29529030
PMCID:
PMC5864096

Dopamine signaling tunes spatial pattern selectivity in C. elegans.

Han B, Dong Y, Zhang L, Liu Y, Rabinowitch I, Bai J.

eLife. 2017; 6.

PubMed [journal]
PMID:
28349862
PMCID:
PMC5370180

Research Summary

Our research goal is to understand how synapses develop into functional circuits. Synaptic connections undergo constant fine-tuning to support information delivery and storage in the brain. Regulation of these connections can occur through altering the strength of existing synapses or through synapse assembly and disassembly. We utilize a combination of genetic, biochemical, imaging, and electrophysiological techniques to ask biological questions at the levels of individual synapses and functional circuits.