Jihong Bai
jbai@fredhutch.orgFred Hutch,
Biophysical and Structural Biology
Cell Signaling & Cell/Environment Interactions
Neuroscience (Area Director)
Molecular and Cellular Basis for Neural Communication
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
Chew YL, Tanizawa Y, Cho Y, Zhao B, Yu AJ, Ardiel EL, Rabinowitch I, Bai J, Rankin CH, Lu H, Beets I, Schafer WR.
Neuron. 2018; 99(6):1233-1246.e6.
- PMID:
- 30146306
- PMCID:
- PMC6162336
Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis.
Poudel KR, Roh-Johnson M, Su A, Ho T, Mathsyaraja H, Anderson S, Grady WM, Moens CB, Conacci-Sorrell M, Eisenman RN, Bai J.
Developmental cell. 2018; 45(6):738-752.e6. NIHMSID: NIHMS974590
- PMID:
- 29920278
- PMCID:
- PMC6095642
Thapliyal S, Vasudevan A, Dong Y, Bai J, Koushika SP, Babu K.
PLoS genetics. 2018; 14(3):e1007263.
- PMID:
- 29529030
- PMCID:
- PMC5864096
Dopamine signaling tunes spatial pattern selectivity in C. elegans.
Han B, Dong Y, Zhang L, Liu Y, Rabinowitch I, Bai J.
eLife. 2017; 6.
- PMID:
- 28349862
- PMCID:
- PMC5370180
Artificial Optogenetic TRN Stimulation of C. elegans.
Rabinowitch I, Treinin M, Bai J.
Bio-protocol. 2016; 6(20). NIHMSID: NIHMS913206
- PMID:
- 29170746
- PMCID:
- PMC5697792
MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation.
Anderson S, Poudel KR, Roh-Johnson M, Brabletz T, Yu M, Borenstein-Auerbach N, Grady WN, Bai J, Moens CB, Eisenman RN, Conacci-Sorrell M.
Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(37):E5481-90.
- PMID:
- 27566402
- PMCID:
- PMC5027433
Poudel KR, Dong Y, Yu H, Su A, Ho T, Liu Y, Schulten K, Bai J.
Molecular biology of the cell. 2016; 27(13):2119-32.
- PMID:
- 27170174
- PMCID:
- PMC4927284
The foundations of cross-modal plasticity.
Rabinowitch I, Bai J.
Communicative & integrative biology. 2016; 9(2):e1158378.
- PMID:
- 27195068
- PMCID:
- PMC4857785
Neuropeptide-Driven Cross-Modal Plasticity following Sensory Loss in Caenorhabditis elegans.
Rabinowitch I, Laurent P, Zhao B, Walker D, Beets I, Schoofs L, Bai J, Schafer WR, Treinin M.
PLoS biology. 2016; 14(1):e1002348.
- PMID:
- 26745270
- PMCID:
- PMC4712962
Synaptojanin cooperates in vivo with endophilin through an unexpected mechanism.
Dong Y, Gou Y, Li Y, Liu Y, Bai J.
eLife. 2015; 4.
- PMID:
- 25918845
- PMCID:
- PMC4435004
Research Summary
Our research goal is to understand how synapses develop into functional circuits. Synaptic connections undergo constant fine-tuning to support information delivery and storage in the brain. Regulation of these connections can occur through altering the strength of existing synapses or through synapse assembly and disassembly. We utilize a combination of genetic, biochemical, imaging, and electrophysiological techniques to ask biological questions at the levels of individual synapses and functional circuits.