faculty

Justin Kollman

jkoll@uw.edu
Associate Professor

University of Washington

Biochemistry

Biophysical and Structural Biology

Cell Signaling & Cell/Environment Interactions

Microbiology, Infection & Immunity

Structure and function of self-assembling cellular machines

Faculty Contact Information

Building: Health Sciences Building Room: J391 Box: 357350 Phone: 206-543-4051 http://sites.uw.edu/jkoll

Research Summary

We use cryo-EM to study the structures of large self assembling macromolecular complexes, including enzyme polymers that regulate cellular metabolism, cytoskeletal structures that organize the intracellular space, and piston-like protein machines that generate force to burst membranes as part of intercellular warfare. In each of these systems protein-protein interactions drive creation of large cellular structures with unique functional properties. We complement our structural work with functional studies using a broad array of biophysical, biochemical, and cell biological approaches.

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Publications

The following publications were retrieved from PubMed:

Computational design of transmembrane pores.

Xu C, Lu P, Gamal El-Din TM, Pei XY, Johnson MC, Uyeda A, Bick MJ, Xu Q, Jiang D, Bai H, Reggiano G, Hsia Y, Brunette TJ, Dou J, Ma D, Lynch EM, Boyken SE, Huang PS, Stewart L, DiMaio F, Kollman JM, Luisi BF, Matsuura T, Catterall WA, Baker D.

Nature. 2020 Sep; 7823(585)129-134

CTP synthase polymerization in germline cells of the developing Drosophila egg supports egg production.

Simonet JC, Foster MJ, Lynch EM, Kollman JM, Nicholas E, O'Reilly AM, Peterson JR.

Biol Open. 2020 Jul 21; 7(9)

Freedom of assembly: metabolic enzymes come together.

Simonet JC, Burrell AL, Kollman JM, Peterson JR.

Mol Biol Cell. 2020 Jun 1; 12(31)1201-1205

Lysogenic host-virus interactions in SAR11 marine bacteria.

Morris RM, Cain KR, Hvorecny KL, Kollman JM.

Nat Microbiol. 2020 Aug; 8(5)1011-1015

Filament formation by metabolic enzymes-A new twist on regulation.

Lynch EM, Kollman JM, Webb BA.

Curr Opin Cell Biol. 2020 Oct; (66)28-33

Accepting Students For:

Rotation, Autumn
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Permanent

Lab Information

Location: University of Washington
Room: 1959 NE Pacific St. Room J-387
Phone: 206-915-4319
Alt Phone: 2069154319
http://sites.uw.edu/jkoll