University of Washington,
Biophysical and Structural Biology (Area Director)
Cell Signaling & Cell/Environment Interactions
Microbiology, Infection & Immunity
Structure and function of self-assembling cellular machines
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We use cryo-EM to study the structures of large self assembling macromolecular complexes, including enzyme polymers that regulate cellular metabolism, cytoskeletal structures that organize the intracellular space, and piston-like protein machines that generate force to burst membranes as part of intercellular warfare. In each of these systems protein-protein interactions drive creation of large cellular structures with unique functional properties. We complement our structural work with functional studies using a broad array of biophysical, biochemical, and cell biological approaches.