Liguo Wang


University of Washington, 

Biophysical and Structural Biology

Cell Signaling & Cell/Environment Interactions

Structural study of membrane proteins using cryo-EM

Faculty Contact Information

Building: HSB Room: G519 Box: 357420 Phone: 206-616-7894 http://wanglab.biostr.washington.edu/

Lab Information

Location: School of Medicine Building: HSB Room: G524 Phone: 206-616-8274 http://wanglab.biostr.washington.edu/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter

Research Summary

Our main research interest lies in probing the structures of membrane proteins and their complexes, and understanding the molecular basis of their biological functions. My aim is to establish an infrastructure wherein the structure of any membrane protein including its complexes can be investigated in any functional state. We have developed a novel and general method, called “random spherically constrained” (RSC) single-particle cryo-EM, to study membrane protein structures in membrane environments. Currently, our research focuses on HCN Channel and BK Channel.