faculty

Roland Strong

rstrong@fredhutch.org
Professor

Fred Hutch

Basic Sciences

Biophysical and Structural Biology

Microbiology, Infection & Immunity

Structural Molecular Immunology, Vaccinology, & Translational Biophysics

Faculty Contact Information

Building: Weintraub Room: B3-163 Box: 358080 Phone: 206-667-5587

Research Summary

Our focus is molecular immunology and vaccinology, studying how polyspecific/degenerate recognition mechanisms affect the functionality of innate and adaptive immunoreceptors, or can be exploited in engineering therapeutics and diagnostics. We study NK and T cell immunoreceptors, antibodies, and Siderocalins. Applications include identification of tumor markers, generating novel immunotherapeutics, and Siderocalin-based radionuclide capture systems. Key approaches include modular protein reengineering, x-ray crystallography, SPR (Biacore) binding affinity/kinetics analyses, and immunoassays.

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Publications

The following publications were retrieved from PubMed:

A TfR-Binding Cystine-Dense Peptide Promotes Blood-Brain Barrier Penetration of Bioactive Molecules.

Crook ZR, Girard E, Sevilla GP, Merrill M, Friend D, Rupert PB, Pakiam F, Nguyen E, Yin C, Ruff RO, Hopping G, Strand AD, Finton KAK, Coxon M, Mhyre AJ, Strong RK, Olson JM.

J Mol Biol. 2020 Jun 26; 14(432)3989-4009

A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure.

Cook Sangar ML, Girard EJ, Hopping G, Yin C, Pakiam F, Brusniak MY, Nguyen E, Ruff R, Gewe MM, Byrnes-Blake K, Nairn NW, Miller DM, Mehlin C, Strand AD, Mhyre AJ, Correnti CE, Strong RK, Simon JA, Olson JM.

Sci Transl Med. 2020 Mar 4; 533(12)

FliC's Hypervariable D3 Domain Is Required for Robust Anti-Flagellin Primary Antibody Responses.

López-Yglesias AH, Lu CC, Zhao X, Chou T, VandenBos T, Strong RK, Smith KD.

Immunohorizons. 2019 Sep 5; 9(3)422-432

Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes.

Bancroft T, DeBuysscher BL, Weidle C, Schwartz A, Wall A, Gray MD, Feng J, Steach HR, Fitzpatrick KS, Gewe MM, Skog PD, Doyle-Cooper C, Ota T, Strong RK, Nemazee D, Pancera M, Stamatatos L, McGuire AT, Taylor JJ.

J Exp Med. 2019 Oct 7; 10(216)2331-2347

Parsing the functional specificity of Siderocalin/Lipocalin 2/NGAL for siderophores and related small-molecule ligands.

Clifton MC, Rupert PB, Hoette TM, Raymond KN, Abergel RJ, Strong RK.

J Struct Biol X. 2019 Apr-Jun; (2)100008

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Lab Information

Location: Fred Hutch
Building: Weintraub
Room: B3-183
Box: 358080
Phone: 206-667-5588
http://research.fhcrc.org/strong/en.html