faculty

Roland Strong

rstrong@fredhutch.org
Professor

Fred Hutch

Basic Sciences

Biophysical and Structural Biology

Cancer Biology

Microbiology, Infection & Immunity

Structural Molecular Immunology, Vaccinology, & Translational Biophysics

Faculty Contact Information

Building: Weintraub Room: B3-163 Box: 358080 Phone: 206-667-5587

Research Summary

Our focus is molecular immunology and vaccinology, studying how polyspecific/degenerate recognition mechanisms affect the functionality of innate and adaptive immunoreceptors, or can be exploited in engineering therapeutics and diagnostics. We study NK and T cell immunoreceptors, antibodies, and Siderocalins. Applications include identification of tumor markers, generating novel immunotherapeutics, and Siderocalin-based radionuclide capture systems. Key approaches include modular protein reengineering, x-ray crystallography, SPR (Biacore) binding affinity/kinetics analyses, and immunoassays.

DEI Statement

I am committed to promoting diversity and inclusion in academia and the broader scientific community, based on an awareness, from an privileged viewpoint, of the manifest hurdles and obstacles that marginalized groups face to this day. This awareness was fostered during my training by my two female mentors, out of four total. This commitment is implemented by both striving to provide a rigorous, but fair, neutral, and supportive, training environment in my group, and by ensuring that research projects are conducted considering factors varying across diverse communities, whenever possible.

Training Summary

Bias Mitigation Education: Grounding and Commitment (Fred Hutch) – 2021

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_639157276fd7be61ff656232&retmode=json
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Publications

The following publications were retrieved from PubMed:

Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation.

Mao Z, Nesterenko PA, McLaughlin J, Deng W, Burton Sojo G, Cheng D, Noguchi M, Chour W, DeLucia DC, Finton KA, Qin Y, Obusan MB, Tran W, Wang L, Bangayan NJ, Ta L, Chen CC, Seet CS, Crooks GM, Phillips JW, Heath JR, Strong RK, Lee JK, Wohlschlegel JA, Witte ON.

Proc Natl Acad Sci U S A. 2022 Aug 2; 31(119)e2203410119

Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager.

Crook ZR, Girard EJ, Sevilla GP, Brusniak MY, Rupert PB, Friend DJ, Gewe MM, Clarke M, Lin I, Ruff R, Pakiam F, Phi TD, Bandaranayake A, Correnti CE, Mhyre AJ, Nairn NW, Strong RK, Olson JM.

Sci Transl Med. 2022 May 18; 645(14)eabn0402

Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays.

Sholukh AM, Fiore-Gartland A, Ford ES, Miner MD, Hou YJ, Tse LV, Kaiser H, Zhu H, Lu J, Madarampalli B, Park A, Lempp FA, St Germain R, Bossard EL, Kee JJ, Diem K, Stuart AB, Rupert PB, Brock C, Buerger M, Doll MK, Randhawa AK, Stamatatos L, Strong RK, McLaughlin C, Huang ML, Jerome KR, Baric RS, Montefiori D, Corey L.

J Clin Microbiol. 2021 Sep 20; 10(59)e0052721

ARTEMIS: A Novel Mass-Spec Platform for HLA-Restricted Self and Disease-Associated Peptide Discovery.

Finton KAK, Brusniak MY, Jones LA, Lin C, Fioré-Gartland AJ, Brock C, Gafken PR, Strong RK.

Front Immunol. 2021; (12)658372

Evaluation of SARS-CoV-2 neutralization assays for antibody monitoring in natural infection and vaccine trials.

Sholukh AM, Fiore-Gartland A, Ford ES, Hou Y, Tse LV, Lempp FA, Kaiser H, Saint Germain R, Bossard E, Kee JJ, Diem K, Stuart AB, Rupert PB, Brock C, Buerger M, Doll MK, Randhawa AK, Stamatatos L, Strong RK, McLaughlin C, Jerome KR, Baric RS, Montefiori D, Corey L.

medRxiv. 2020 Dec 8;



PubMed Collection Link

Accepting Students For:

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Lab Information

Location: Fred Hutch
Building: Weintraub
Room: B3-183
Box: 358080
Phone: 206-667-5588
http://research.fhcrc.org/strong/en.html