Roland Strong
rstrong@fhcrc.orgFred Hutch,
Biophysical and Structural Biology
Microbiology, Infection & Immunity
Structural Molecular Immunology, Vaccinology, & Translational Biophysics
Faculty Contact Information
Lab Information
Publications
Patient HLA Germline Variation and Transplant Survivorship.
Petersdorf EW, Stevenson P, Malkki M, Strong RK, Spellman SR, Haagenson MD, Horowitz MM, Gooley T, Wang T.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018; 36(24):2524-2531.
- PMID:
- 29902106
- PMCID:
- PMC6097831
Crook ZR, Sevilla GP, Friend D, Brusniak MY, Bandaranayake AD, Clarke M, Gewe M, Mhyre AJ, Baker D, Strong RK, Bradley P, Olson JM.
Nature communications. 2018; 9(1):1072.
- PMID:
- 29523778
- PMCID:
- PMC5844863
Screening, large-scale production and structure-based classification of cystine-dense peptides.
Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl CD, Olson JM, Strong RK.
Nature structural & molecular biology. 2018; 25(3):270-278. NIHMSID: NIHMS937122
- PMID:
- 29483648
- PMCID:
- PMC5840021
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets.
Crook ZR, Sevilla GP, Friend D, Brusniak MY, Bandaranayake AD, Clarke M, Gewe M, Mhyre AJ, Baker D, Strong RK, Bradley P, Olson JM.
Nature communications. 2017; 8(1):2244.
- PMID:
- 29269835
- PMCID:
- PMC5740061
Chelation and stabilization of berkelium in oxidation state +IV.
Deblonde GJ, Sturzbecher-Hoehne M, Rupert PB, An DD, Illy MC, Ralston CY, Brabec J, de Jong WA, Strong RK, Abergel RJ.
Nature chemistry. 2017; 9(9):843-849.
- PMID:
- 28837177
Control of Tumor Initiation by NKG2D Naturally Expressed on Ovarian Cancer Cells.
Cai X, Caballero-Benitez A, Gewe MM, Jenkins IC, Drescher CW, Strong RK, Spies T, Groh V.
Neoplasia (New York, N.Y.). 2017; 19(6):471-482.
- PMID:
- 28499126
- PMCID:
- PMC5429243
Captain I, Deblonde GJ, Rupert PB, An DD, Illy MC, Rostan E, Ralston CY, Strong RK, Abergel RJ.
Inorganic chemistry. 2016; 55(22):11930-11936.
- PMID:
- 27802058
Disposal of iron by a mutant form of lipocalin 2.
Barasch J, Hollmen M, Deng R, Hod EA, Rupert PB, Abergel RJ, Allred BE, Xu K, Darrah SF, Tekabe Y, Perlstein A, Wax R, Bruck E, Stauber J, Corbin KA, Buchen C, Slavkovich V, Graziano J, Spitalnik SL, Bao G, Strong RK, Qiu A.
Nature communications. 2016; 7:12973.
- PMID:
- 27796299
- PMCID:
- PMC5095531
HLA-F and MHC-I Open Conformers Bind Natural Killer Cell Ig-Like Receptor KIR3DS1.
Burian A, Wang KL, Finton KA, Lee N, Ishitani A, Strong RK, Geraghty DE.
PloS one. 2016; 11(9):e0163297.
- PMID:
- 27649529
- PMCID:
- PMC5029895
The Broadly Neutralizing, Anti-HIV Antibody 4E10: an Open and Shut Case?
Strong RK, Finton KA.
Journal of virology. 2016; 90(6):3274-5.
- PMID:
- 26921372
- PMCID:
- PMC4810635
Research Summary
Our research focus is molecular immunology and vaccinology, studying how recognition mechanisms increase the breadth and utility of innate and adaptive immunoreceptors, and can be exploited in engineering therapeutics and diagnostics, and immunogens that elicit targeted responses. We use biophysical approaches to study NK, T, and B cell receptors, understand immunorecognition of siderophores, further prophylactic and therapeutic vaccine development, and engineer targeted immunotheranostics. Key approaches include macromolecular structure determination by x-ray crystallography and surface plasm