faculty

Suzanne Hoppins

shoppins@uw.edu
Assistant Professor

University of Washington

Biochemistry

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Mechanism and regulation of mitochondrial fusion.

Faculty Contact Information

Building: Health Sciences Building Room: J383 Box: Box 357350 Phone: 206-616-7565 http://blogs.uw.edu/shoppins/

Research Summary

Mitochondrial membrane fusion is mechanistically unique and poorly understood. Mitochondrial dynamics are essential for mitochondrial function and are also integrated with other processes such as cell cycle progression, cellular immune responses, and apoptotic cell death. Impaired mitochondrial fusion leads to general mitochondrial dysfunction, which has been implicated in several significant public health burdens including Alzheimer’s disease and cancer.

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Publications

The following publications were retrieved from PubMed:

Mitochondrial dynamics and their potential as a therapeutic target.

Whitley BN, Engelhart EA, Hoppins S.

Mitochondrion. 2019 Jun 19;

Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2.

Sloat SR, Whitley BN, Engelhart EA, Hoppins S.

Mol Biol Cell. 2019 Aug 1; 17(30)2309-2319

Aberrant Drp1-mediated mitochondrial division presents in humans with variable outcomes.

Whitley BN, Lam C, Cui H, Haude K, Bai R, Escobar L, Hamilton A, Brady L, Tarnopolsky MA, Dengle L, Picker J, Lincoln S, Lackner LL, Glass IA, Hoppins S.

Hum Mol Genet. 2018 Nov 1; 21(27)3710-3719

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Lab Information

Location: University of Washington
Building: Health Sciences Building
Room: J379
Box: Box 357350
Phone: 206-616-8529
http://blogs.uw.edu/shoppins/