University of Washington,
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Mechanism and regulation of mitochondrial fusion.
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Mitochondrial membrane fusion is mechanistically unique and poorly understood. Mitochondrial dynamics are essential for mitochondrial function and are also integrated with other processes such as cell cycle progression, cellular immune responses, and apoptotic cell death. Impaired mitochondrial fusion leads to general mitochondrial dysfunction, which has been implicated in several significant public health burdens including Alzheimer’s disease and cancer.