faculty

Suzanne Hoppins

shoppins@uw.edu

University of Washington, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Mechanism and regulation of mitochondrial fusion.

Faculty Contact Information

Building: Health Sciences Building Room: J383 Box: Box 357350 Phone: 206-616-7565 http://blogs.uw.edu/shoppins/

Lab Information

Location: University of Washington Building: Health Sciences Building Room: J379 Box: Box 357350 Phone: 206-616-8529 http://blogs.uw.edu/shoppins/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Mitochondrial dynamics and their potential as a therapeutic target.

Whitley BN, Engelhart EA, Hoppins S.

Mitochondrion. 2019 Jun 19;

Identification of a Mitofusin specificity region that confers unique activities to Mfn1 and Mfn2.

Sloat SR, Whitley BN, Engelhart EA, Hoppins S.

Mol Biol Cell. 2019 Jun 12; mbcE19050291

Aberrant Drp1-mediated mitochondrial division presents in humans with variable outcomes.

Whitley BN, Lam C, Cui H, Haude K, Bai R, Escobar L, Hamilton A, Brady L, Tarnopolsky MA, Dengle L, Picker J, Lincoln S, Lackner LL, Glass IA, Hoppins S.

Hum Mol Genet. 2018 Nov 1; 21(27)3710-3719

Research Summary

Mitochondrial membrane fusion is mechanistically unique and poorly understood. Mitochondrial dynamics are essential for mitochondrial function and are also integrated with other processes such as cell cycle progression, cellular immune responses, and apoptotic cell death. Impaired mitochondrial fusion leads to general mitochondrial dysfunction, which has been implicated in several significant public health burdens including Alzheimer’s disease and cancer.