Valeri Vasioukhin
vvasiouk@fhcrc.orgFred Hutch,
Cancer Biology (Area Director)
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
cell polarity and cell-cell adhesion in normal development and cancer
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells.
Jossin Y, Lee M, Klezovitch O, Kon E, Cossard A, Lien WH, Fernandez TE, Cooper JA, Vasioukhin V.
Developmental cell. 2017; 41(5):481-495.e5. NIHMSID: NIHMS874323
- PMID:
- 28552558
- PMCID:
- PMC5519327
Beattie R, Postiglione MP, Burnett LE, Laukoter S, Streicher C, Pauler FM, Xiao G, Klezovitch O, Vasioukhin V, Ghashghaei TH, Hippenmeyer S.
Neuron. 2017; 94(3):517-533.e3.
- PMID:
- 28472654
Sreenath TL, Macalindong SS, Mikhalkevich N, Sharad S, Mohamed A, Young D, Borbiev T, Xavier C, Gupta R, Jamal M, Babcock K, Tan SH, Nevalainen MT, Dobi A, Petrovics G, Sesterhenn IA, Rosner IL, Bieberich CJ, Nelson P, Vasioukhin V, Srivastava S.
Scientific reports. 2017; 7(1):1109.
- PMID:
- 28439080
- PMCID:
- PMC5430720
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.
Kwan J, Sczaniecka A, Heidary Arash E, Nguyen L, Chen CC, Ratkovic S, Klezovitch O, Attisano L, McNeill H, Emili A, Vasioukhin V.
Genes & development. 2016; 30(24):2696-2709.
- PMID:
- 28087714
- PMCID:
- PMC5238729
Li P, Silvis MR, Honaker Y, Lien WH, Arron ST, Vasioukhin V.
Genes & development. 2016; 30(7):798-811.
- PMID:
- 27013234
- PMCID:
- PMC4826396
Cadherin signaling: keeping cells in touch.
Klezovitch O, Vasioukhin V.
F1000Research. 2015; 4(F1000 Faculty Rev):550.
- PMID:
- 26339481
- PMCID:
- PMC4544379
Nguyen LT, Tretiakova MS, Silvis MR, Lucas J, Klezovitch O, Coleman I, Bolouri H, Kutyavin VI, Morrissey C, True LD, Nelson PS, Vasioukhin V.
Cancer cell. 2015; 27(6):797-808. NIHMSID: NIHMS690705
- PMID:
- 26058078
- PMCID:
- PMC4461839
Wang SH, Celic I, Choi SY, Riccomagno M, Wang Q, Sun LO, Mitchell SP, Vasioukhin V, Huganir RL, Kolodkin AL.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014; 34(38):12745-61.
- PMID:
- 25232112
- PMCID:
- PMC4166160
Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis.
Tang X, Mahajan SS, Nguyen LT, Béliveau F, Leduc R, Simon JA, Vasioukhin V.
Oncotarget. 2014; 5(5):1352-62.
- PMID:
- 24657880
- PMCID:
- PMC4012739
Your gut is right to turn left.
Klezovitch O, Vasioukhin V.
Developmental cell. 2013; 26(6):553-4. NIHMSID: NIHMS526354
- PMID:
- 24091006
- PMCID:
- PMC3888821
Research Summary
Three major research directions:
1. Cell polarity mechanisms responsible for asymmetric cell divisions that help to ensure the maintenance of pluripotent stem cells and normal differentiation.
2. Cell-cell adhesion structures as biosensors of cellular microenvironment involved in regulation of cell proliferation, differentiation and programmed cell death?
3. Molecular mechanisms and novel therapeutic approaches in human prostate cancer.