Biophysical and Structural Biology
Gene Expression, Cell Cycle & Chromosome Biology
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Aneuploidy is the most common chromosome abnormality in cancers and is the cause of birth defects and other diseases. We therefore study the controls over cell division and chromosome segregation that ensure accurate self-renewal, proliferation and development. We take an interdisciplinary approach that combines biophysical, cell biological, biochemical and genetic techniques to tackle these questions using yeast and human cells as model systems.