faculty

Sue Biggins

sbiggins@fredhutch.org
Member

Fred Hutch

Basic Sciences

Biophysical and Structural Biology

Cancer Biology

Gene Expression, Cell Cycle & Chromosome Biology

Chromosome Segregation

Faculty Contact Information

Building: Weintraub Room: A2-155 Box: A2-168 Phone: 206-667-1351 http://research.fhcrc.org/biggins/en.html

Research Summary

Aneuploidy is the most common chromosome abnormality in cancers and is the cause of birth defects and other diseases. We therefore study the controls over cell division and chromosome segregation that ensure accurate self-renewal, proliferation and development. We take an interdisciplinary approach that combines biophysical, cell biological, biochemical and genetic techniques to tackle these questions using yeast and human cells as model systems.

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Publications

The following publications were retrieved from PubMed:

Kinetochore-associated Stu2 promotes chromosome biorientation in vivo.

Miller MP, Evans RK, Zelter A, Geyer EA, MacCoss MJ, Rice LM, Davis TN, Asbury CL, Biggins S.

PLoS Genet. 2019 Oct; 10(15)e1008423

Autophosphorylation is sufficient to release Mps1 kinase from native kinetochores.

Koch LB, Opoku KN, Deng Y, Barber A, Littleton AJ, London N, Biggins S, Asbury CL.

Proc Natl Acad Sci U S A. 2019 Aug 27; 35(116)17355-17360

The Bub1-TPR Domain Interacts Directly with Mad3 to Generate Robust Spindle Checkpoint Arrest.

Leontiou I, London N, May KM, Ma Y, Grzesiak L, Medina-Pritchard B, Amin P, Jeyaprakash AA, Biggins S, Hardwick KG.

Curr Biol. 2019 Jul 22; 14(29)2407-2414.e7

A Kinesin-5, Cin8, Recruits Protein Phosphatase 1 to Kinetochores and Regulates Chromosome Segregation.

Suzuki A, Gupta A, Long SK, Evans R, Badger BL, Salmon ED, Biggins S, Bloom K.

Curr Biol. 2018 Sep 10; 17(28)2697-2704.e3

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Lab Information

Location: Fred Hutch
Building: Weintraub
Room: A2-149
Box: A2-168
Phone: 206-667-5766
http://research.fhcrc.org/biggins/en.html