faculty

Sue Biggins (she/her)

sbiggins@fredhutch.org

Professor

Fred Hutch

Basic Sciences

Biophysical and Structural Biology

Cancer Biology

Gene Expression, Cell Cycle & Chromosome Biology

Chromosome Segregation

Faculty Contact Information

Building: Weintraub Room: A2-155 Box: A2-168 Phone: 206-667-1351 http://research.fhcrc.org/biggins/en.html

LinkedIn Profile

Research Summary

Aneuploidy is the most common chromosome abnormality in cancers and is the cause of birth defects and other diseases. We therefore study the controls over cell division and chromosome segregation that ensure accurate self-renewal, proliferation and development. We take an interdisciplinary approach that combines biophysical, cell biological, biochemical and genetic techniques to tackle these questions using yeast and human cells as model systems.

DEI Statement

I seek to ensure a diverse and supportive lab environment where the opinions and perspectives of all lab members are respected and valued. I believe an inclusive and safe environment promotes scientific creativity and progress and we strive to maintain this culture. In addition to promoting diversity and inclusion in the lab, I am committed to this at the institutional level as well. I am a member of the Executive committee for the Office of DEI and I am the Executive Sponsor for Hutch United, a community that fosters a supportive and inclusive community for underrepresented scientists.

Training Summary

2018: Government to Government training to improve cultural awareness and further relationships with WA state’s federally recognized tribes

2020: University of Wisconsin CIMER training on Culturally Aware Mentoring

2021-2022: HHMI Gilliam Advisor mentorship training program; this is a year long serives of activities aimed at development of mentorship skills

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Publications

The following publications were retrieved from PubMed:

Computed structures of core eukaryotic protein complexes.

Humphreys IR, Pei J, Baek M, Krishnakumar A, Anishchenko I, Ovchinnikov S, Zhang J, Ness TJ, Banjade S, Bagde SR, Stancheva VG, Li XH, Liu K, Zheng Z, Barrero DJ, Roy U, Kuper J, Fernández IS, Szakal B, Branzei D, Rizo J, Kisker C, Greene EC, Biggins S, Keeney S, Miller EA, Fromme JC, Hendrickson TL, Cong Q, Baker D.

Science. 2021 Dec 10; 6573(374)eabm4805

Kinetochore-bound Mps1 regulates kinetochore-microtubule attachments via Ndc80 phosphorylation.

Sarangapani KK, Koch LB, Nelson CR, Asbury CL, Biggins S.

J Cell Biol. 2021 Dec 6; 12(220)

chTOG is a conserved mitotic error correction factor.

Herman JA, Miller MP, Biggins S.

Elife. 2020 Dec 30; (9)

Fifty years of cycling.

Biggins S, Hartwell L, Toczyski D.

Mol Biol Cell. 2020 Dec 15; 26(31)2868-2870

Cdk1 Phosphorylation of the Dam1 Complex Strengthens Kinetochore-Microtubule Attachments.

Gutierrez A, Kim JO, Umbreit NT, Asbury CL, Davis TN, Miller MP, Biggins S.

Curr Biol. 2020 Nov 16; 22(30)4491-4499.e5

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Permanent

Lab Information

Location: Fred Hutch
Building: Weintraub
Room: A2-149
Box: A2-025
Phone: 206-667-5766
http://research.fhcrc.org/biggins/en.html