faculty

Sue Biggins (she/her)

sbiggins@fredhutch.org
Professor

Fred Hutch

Basic Sciences

Biophysical and Structural Biology

Cancer Biology

Gene Expression, Cell Cycle & Chromosome Biology

Chromosome Segregation

Faculty Contact Information

Building: Weintraub Room: A2-155 Box: A2-168 Phone: 206-667-1351 http://research.fhcrc.org/biggins/en.html

Research Summary

Aneuploidy is the most common chromosome abnormality in cancers and is the cause of birth defects and other diseases. We therefore study the controls over cell division and chromosome segregation that ensure accurate self-renewal, proliferation and development. We take an interdisciplinary approach that combines biophysical, cell biological, biochemical and genetic techniques to tackle these questions using yeast and human cells as model systems.

DEI Statement

I seek to ensure a diverse and supportive lab environment where the opinions and perspectives of all lab members are respected and valued. I believe an inclusive and safe environment promotes scientific creativity and progress and we strive to maintain this culture. In addition to promoting diversity and inclusion in the lab, I am committed to this at the institutional level as well. I am a member of the Executive committee for the Office of DEI and partner with Hutch United, a community that fosters a supportive and inclusive community for underrepresented scientists, to provide events to support DEI. I am an HHMI Gilliam Advisor and have provided support through this program to initiate the first monthly facilitated BIPOC group sessions. I am also an ASCB Mosaic program mentor.

Training Summary

HHMI Gilliam Advisor mentorship training program; this is a year long series of monthly activities aimed at development of mentorship skills – 2021-2022

University of Wisconsin CIMER training on Culturally Aware Mentoring – 2020

Government to Government training to improve cultural awareness and further relationships with WA state’s federally recognized tribes – 2018

ASCB Mosaic Mentor

Actively partner with office of DEI at Fred Hutch to address DEI issues throughout the Center.

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Publications

The following publications were retrieved from PubMed:

Microtubule integrity regulates budding yeast RAM pathway gene expression.

Lee CH, Biggins S.

Front Cell Dev Biol. 2022; (10)989820

Functional dissection of human mitotic genes using CRISPR-Cas9 tiling screens.

Herman JA, Arora S, Carter L, Zhu J, Biggins S, Paddison PJ.

Genes Dev. 2022 Apr 1; 7-8(36)495-510

Tension can directly suppress Aurora B kinase-triggered release of kinetochore-microtubule attachments.

de Regt AK, Clark CJ, Asbury CL, Biggins S.

Nat Commun. 2022 Apr 20; 1(13)2152

A transcriptional roadblock protects yeast centromeres.

Hedouin S, Logsdon GA, Underwood JG, Biggins S.

Nucleic Acids Res. 2022 Aug 12; 14(50)7801-7815

Computed structures of core eukaryotic protein complexes.

Humphreys IR, Pei J, Baek M, Krishnakumar A, Anishchenko I, Ovchinnikov S, Zhang J, Ness TJ, Banjade S, Bagde SR, Stancheva VG, Li XH, Liu K, Zheng Z, Barrero DJ, Roy U, Kuper J, Fernández IS, Szakal B, Branzei D, Rizo J, Kisker C, Greene EC, Biggins S, Keeney S, Miller EA, Fromme JC, Hendrickson TL, Cong Q, Baker D.

Science. 2021 Dec 10; 6573(374)eabm4805

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Lab Information

Location: Fred Hutch
Building: Weintraub
Room: A2-149
Box: A2-025
Phone: 206-667-5766
http://research.fhcrc.org/biggins/en.html