Linda Wordeman
worde@uw.eduUniversity of Washington,
Cancer Biology
Developmental Biology, Stem Cells & Aging
Gene Expression, Cell Cycle & Chromosome Biology (Area Director)
Microtubule dynamics and Cell Division
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells
Diaz P, Horne E, Xu C, Hamel E, Wagenbach M, Petrov R, Uhlenbruck B, Haas B, Hothi P, Wordeman L, Gussio R, Stella N.
European journal of medicinal chemistry. Forthcoming;
Parker AL, Teo WS, Pandzic E, Vicente JJ, McCarroll JA, Wordeman L, Kavallaris M.
Life science alliance. 2018; 1(2). NIHMSID: NIHMS978392
- PMID:
- 30079401
- PMCID:
- PMC6070155
Arf GAPs and molecular motors.
Luo R, Reed CE, Sload JA, Wordeman L, Randazzo PA, Chen PW.
Small GTPases. 2017; :1-14.
- PMID:
- 28430047
Decarreau J, Wagenbach M, Lynch E, Halpern AR, Vaughan JC, Kollman J, Wordeman L.
Nature cell biology. 2017; 19(4):384-390. NIHMSID: NIHMS849667
- PMID:
- 28263957
- PMCID:
- PMC5376238
Luo R, Chen PW, Wagenbach M, Jian X, Jenkins L, Wordeman L, Randazzo PA.
The Journal of biological chemistry. 2016; 291(49):25761.
- PMID:
- 27913662
- PMCID:
- PMC5207271
Luo R, Chen PW, Wagenbach M, Jian X, Jenkins L, Wordeman L, Randazzo PA.
The Journal of biological chemistry. 2016; 291(41):21350-21362.
- PMID:
- 27531749
- PMCID:
- PMC5076806
Cherry AE, Haas BR, Naydenov AV, Fung S, Xu C, Swinney K, Wagenbach M, Freeling J, Canton DA, Coy J, Horne EA, Rickman B, Vicente JJ, Scott JD, Ho RJ, Liggitt D, Wordeman L, Stella N.
Molecular cancer therapeutics. 2016; 15(9):2018-29. NIHMSID: NIHMS795277
- PMID:
- 27325686
- PMCID:
- PMC5010991
Molecular insight into the regulation and function of MCAK.
Ritter A, Kreis NN, Louwen F, Wordeman L, Yuan J.
Critical reviews in biochemistry and molecular biology. 2016; 51(4):228-45.
- PMID:
- 27146484
Divergent microtubule assembly rates after short- versus long-term loss of end-modulating kinesins.
Wordeman L, Decarreau J, Vicente JJ, Wagenbach M.
Molecular biology of the cell. 2016; 27(8):1300-9.
- PMID:
- 26912793
- PMCID:
- PMC4831883
Oxidative stress decreases microtubule growth and stability in ventricular myocytes.
Drum BM, Yuan C, Li L, Liu Q, Wordeman L, Santana LF.
Journal of molecular and cellular cardiology. 2016; 93:32-43. NIHMSID: NIHMS766338
- PMID:
- 26902968
- PMCID:
- PMC4902331
Research Summary
My lab studies microtubule dynamics, microtubule motors and chromosome segregation. We use human and mammalian cell lines to investigate the impact of microtubule motors and regulators of microtubule polymerization on the fidelity of cell division and chromosome instability. We use high resolution and super-resolution live cell imaging and total internal fluorescence (TIRF) microscopy in conjunction with fluorescent proteins, bio-sensors and gene-edited cell lines to investigate dynamic processes that govern chromosome segregation during mitosis.