faculty

Linda Wordeman

worde@uw.edu

University of Washington, 

Cancer Biology

Developmental Biology, Stem Cells & Aging

Gene Expression, Cell Cycle & Chromosome Biology (Area Director)

Microtubule dynamics and Cell Division

Faculty Contact Information

Building: Health Sciences Building Room: G403 Box: 357290 http://faculty.washington.edu/worde/

Lab Information

Location: University of Washington Building: Health Sciences Building Room: H412, H418 Box: 357290 Phone: 206-543-9184 http://faculty.washington.edu/worde/

Accepting Students For:

Rotation, Spring

Publications

Arf GAPs and molecular motors.

Luo R, Reed CE, Sload JA, Wordeman L, Randazzo PA, Chen PW.

Small GTPases. 2019; 10(3):196-209.

PubMed [journal]
PMID:
28430047
PMCID:
PMC6548297

Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells

Diaz P, Horne E, Xu C, Hamel E, Wagenbach M, Petrov R, Uhlenbruck B, Haas B, Hothi P, Wordeman L, Gussio R, Stella N.

European journal of medicinal chemistry. Forthcoming;

My Bibliography [journal]

Physical exertion exacerbates decline in the musculature of an animal model of Duchenne muscular dystrophy.

Hughes KJ, Rodriguez A, Flatt KM, Ray S, Schuler A, Rodemoyer B, Veerappan V, Cuciarone K, Kullman A, Lim C, Gutta N, Vemuri S, Andriulis V, Niswonger D, Barickman L, Stein W, Singhvi A, Schroeder NE, Vidal-Gadea AG.

Proceedings of the National Academy of Sciences of the United States of America. 2019; 116(9):3508-3517.

PubMed [journal]
PMID:
30755520
PMCID:
PMC6397527

Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells.

Diaz P, Horne E, Xu C, Hamel E, Wagenbach M, Petrov RR, Uhlenbruck B, Haas B, Hothi P, Wordeman L, Gussio R, Stella N.

European journal of medicinal chemistry. 2018; 159:74-89.

PubMed [journal]
PMID:
30268825

ő≤-tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cells.

Parker AL, Teo WS, Pandzic E, Vicente JJ, McCarroll JA, Wordeman L, Kavallaris M.

Life science alliance. 2018; 1(2). NIHMSID: NIHMS978392

PubMed [journal]
PMID:
30079401
PMCID:
PMC6070155

Research Summary

My lab studies microtubule dynamics, microtubule motors and chromosome segregation. We use human and mammalian cell lines to investigate the impact of microtubule motors and regulators of microtubule polymerization on the fidelity of cell division and chromosome instability. We use high resolution and super-resolution live cell imaging and total internal fluorescence (TIRF) microscopy in conjunction with fluorescent proteins, bio-sensors and gene-edited cell lines to investigate dynamic processes that govern chromosome segregation during mitosis.