faculty

Harmit Malik

hsmalik@fhcrc.org

Professor

Fred Hutch

Basic Sciences

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Evolutionary and functional studies of genetic conflicts

Faculty Contact Information

Building: Weintraub Building Room: A2-205 Box: A2-025 Phone: 206-667-5204 Alt Phone: 206-667-4512 http://research.fhcrc.org/malik/en.html

Research Summary

My lab studies how eukaryotic genetics and epigenetics have been shaped by diverse genetic conflicts. Projects in the lab can be roughly classified into two types: extrinsic (between genomes) conflicts that shape genes involved in host-pathogen interactions, and intrinsic (within genome) conflicts that shape eukaryotic genomes. We use studies that combine insights from evolutionary biology together with molecular/ cellular biology, virology, and genetics. While our primary research organism is Drosophila, we study a variety of model and non-systems depending on the research question.

DEI Statement

My lab is committed to enhancing diversity by increasing the participation of individuals from diverse backgrounds, including those from underrepresented groups, in biomedical sciences. Two of the eleven students who have finished their Ph.D. studies in my lab are from underrepresented communities. We have trained nearly two dozen undergraduate students from underrepresented groups in post-baccalaureate or research technician positions, and in summer internships; the vast majority of these students went on to Ph.D. or M.D. or M.D./Ph.D. studies.

Training Summary

My lab is also involved in the training of graduate and postdoctoral trainees. Our work is interdisciplinary and our trainees are trained in evolutionary, computational, cell and molecular biology. I consider my trainees and their success as my most significant contribution to science. The Malik lab seeks graduate trainees who desire being in a lab full of diverse projects, where they can design and implement an independent research program. We aim to provide a supportive and enriching training environment that will enable students to achieve their goals.

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Publications

The following publications were retrieved from PubMed:

The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity.

Forsberg KJ, Schmidtke DT, Werther R, Uribe RV, Hausman D, Sommer MOA, Stoddard BL, Kaiser BK, Malik HS.

PLoS Biol. 2021 Oct 13; 10(19)e3001428

Schroeder CM, Tomlin SA, Mejia Natividad I, Valenzuela JR, Young JM, Malik HS.

Elife. 2021 Jul 20; (10)

Gametic specialization of centromeric histone paralogs in Drosophila virilis.

Kursel LE, McConnell H, de la Cruz AFA, Malik HS.

Life Sci Alliance. 2021 Jul; 7(4)

Putting the brakes on centromere drive in Mimulus.

Chang CH, Malik HS.

PLoS Genet. 2021 Apr; 4(17)e1009494

A balancing act between primate lentiviruses and their receptor.

Ohainle M, Malik HS.

Proc Natl Acad Sci U S A. 2021 May 18; 20(118)

PubMed Collection Link

Accepting Students For:

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Lab Information

Location: Fred Hutch
Building: Weintraub
Room: A2-205
Box: A2-025
Phone: 206-667-4512
http://research.fhcrc.org/malik/en.html