faculty

Lakshmi Rajagopal

LAKSHMI.RAJAGOPAL@seattlechildrens.org
Professor

Seattle Childrens Research Institute

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

The Rajagopal Lab utilizes genetic, molecular, biochemical and proteomic approaches to study infectious diseases caused by bacteria.

Faculty Contact Information

Building: SCRI/307 Westlake Room: #223 Box: 359300/307W Phone: 206-884-7336 http://www.seattlechildrens.org/research/global-infectious-disease-research/rajagopal-lab/

Research Summary

The human pathogens that we study are group B Streptococcus and Staphylococcus aureus. Although both GBS and S. aureus are commensal organisms, these bacteria can also become disease-causing pathogens. Research projects on GBS are focused on understanding how the pathogen migrates through different host niches during infections. Research includes identifying the environmental cues/signals that are sensed by the pathogen for regulation of toxins and other virulence factors. Our studies on S. aureus are focused on elucidating factors that regulate antibiotic resistance & virulence of pathogen.

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Publications

The following publications were retrieved from PubMed:

Bacterial and Host Determinants of Group B Streptococcal Vaginal Colonization and Ascending Infection in Pregnancy.

Brokaw A, Furuta A, Dacanay M, Rajagopal L, Adams Waldorf KM.

Front Cell Infect Microbiol. 2021; (11)720789

The oxidatively damaged DNA and amyloid-β oligomer hypothesis of Alzheimer's disease.

Sanders OD, Rajagopal L, Rajagopal JA.

Free Radic Biol Med. 2021 Sep 8;

Non-human Primate Models to Investigate Mechanisms of Infection-Associated Fetal and Pediatric Injury, Teratogenesis and Stillbirth.

Li M, Brokaw A, Furuta AM, Coler B, Obregon-Perko V, Chahroudi A, Wang HY, Permar SR, Hotchkiss CE, Golos TG, Rajagopal L, Adams Waldorf KM.

Front Genet. 2021; (12)680342

Does oxidatively damaged DNA drive amyloid-β generation in Alzheimer's disease? A hypothesis.

Sanders OD, Rajagopal L, Rajagopal JA.

J Neurogenet. 2021 Jul 20; 1-7

Group B Streptococcus cpsE Is Required for Serotype V Capsule Production and Aids in Biofilm Formation and Ascending Infection of the Reproductive Tract during Pregnancy.

Noble K, Lu J, Guevara MA, Doster RS, Chambers SA, Rogers LM, Moore RE, Spicer SK, Eastman AJ, Francis JD, Manning SD, Rajagopal L, Aronoff DM, Townsend SD, Gaddy JA.

ACS Infect Dis. 2021 Sep 10; 9(7)2686-2696

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Lab Information

Location: SCRI
Building: 307 Westlake
Room: 2nd Floor
Box: 359300/307W
http://www.seattlechildrens.org/research/global-infectious-disease-research/rajagopal-lab/