faculty

David Beier

david.beier@seattlechildrens.org
Professor

Seattle Childrens Research Institute

Developmental Biology, Stem Cells & Aging

Developmental genetic analysis in model organisms.

Faculty Contact Information

Building: Jack MacDonald Building, 1900 9th Ave, Seattle, 98101 Room: 535 Box: Jack MacDonald Building - Office 535 Phone: 206-884-1419 http://depts.washington.edu/cdbrm/wordpress/research-labs/beier-lab/

Research Summary

My research focuses on using genetic methods for the identification of genes causing human disease and developmental defects. We have positionally cloned the causal gene for over 50 mutations, many encoding previously uncharacterized genes. Our research has used many of the major tools in model organism analysis, including gene mapping and genomic analysis, characterization of modifying genes and QTLs, ENU mutagenesis for developmental investigation, SNP genotyping and next-gen sequencing for genetic mapping in the mouse and zebrafish, and genome-editing methods such as CRISPR.

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Publications

The following publications were retrieved from PubMed:

Reelin Mediates Hippocampal Cajal-Retzius Cell Positioning and Infrapyramidal Blade Morphogenesis.

Ha S, Tripathi PP, Daza RA, Hevner RF, Beier DR.

J Dev Biol. 2020 Sep 18; 3(8)

Differential requirements of tubulin genes in mammalian forebrain development.

Bittermann E, Abdelhamed Z, Liegel RP, Menke C, Timms A, Beier DR, Stottmann RW.

PLoS Genet. 2019 Aug; 8(15)e1008243

Loss of function of Colgalt1 disrupts collagen post-translational modification and causes musculoskeletal defects.

Geister KA, Lopez-Jimenez AJ, Houghtaling S, Ho TH, Vanacore R, Beier DR.

Dis Model Mech. 2019 Jun 17; 6(12)

Applicability of the Mutation-Selection Balance Model to Population Genetics of Heterozygous Protein-Truncating Variants in Humans.

Weghorn D, Balick DJ, Cassa C, Kosmicki JA, Daly MJ, Beier DR, Sunyaev SR.

Mol Biol Evol. 2019 Aug 1; 8(36)1701-1710

Reply to 'Selective effects of heterozygous protein-truncating variants'.

Cassa CA, Weghorn D, Balick DJ, Jordan DM, Nusinow D, Samocha KE, O'Donnell-Luria A, MacArthur DG, Daly MJ, Beier DR, Sunyaev SR.

Nat Genet. 2019 Jan; 1(51)3-4

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Lab Information

Location: Seattle Children's Research Institute
Building: Jack MacDonald Building
http://depts.washington.edu/cdbrm/wordpress/research-labs/beier-lab/