Gene Expression, Cell Cycle & Chromosome Biology
Regulation of the localization and activity of Mps1 kinase at the kinetochore
The precise distribution of genetic information during cell division is required for the survival and health of living organisms. Duplicated chromosomes must attach to microtubules via protein complexes called kinetochores to be segregated correctly into the two daughter cells. To ensure genome integrity, the cell has mechanisms to promote and sense productive kinetochore-microtubule (KT-MT) attachments. I am studying how an essential regulator of the KT-MT attachment, a protein kinase called Mps1, localizes to KTs and influences the attachment state.