student

Erica Hildebrand

ehildebr@uw.edu

Fred Hutch

Basic Sciences

Gene Expression, Cell Cycle & Chromosome Biology

Entry Quarter: Autumn 2010

Current Position

Regulation of centromeric histone localization in budding yeast

Defense date: 10/17/2016
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Publications

The following publications were retrieved from PubMed:

Mechanisms and Functions of Chromosome Compartmentalization.

Hildebrand EM, Dekker J.

Trends Biochem Sci. 2020 May; 5(45)385-396

Histone H4 Facilitates the Proteolysis of the Budding Yeast CENP-ACse4 Centromeric Histone Variant.

Deyter GM, Hildebrand EM, Barber AD, Biggins S.

Genetics. 2017 Jan; 1(205)113-124



Publications Link

Research Summary

My PhD research was focused on the question of how the centromeric histone variant (CENP-A/Cse4) is regulated so that it is bound only to the centromere and not to other parts of the genome. I used ChIP-seq to measure the genome-wide mislocalization pattern of CENP-A/Cse4 in the absence of Psh1, the E3 ubiquitin ligase that targets CENP-A/Cse4 for degradation and I also investigated other chromatin-based processes that control CENP-A/Cse4 localization to prevent ectopic nucleosome formation on chromosome arms.

Lab Information