student

Nicole Iranon

iranon@uw.edu

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Entry Quarter: Summer 2011

Fasting protects against proteostasis defects induced by hypoxia

Defense date: 05/21/2018
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_5fc111000b74a62a5518af75&retmode=json
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Publications

The following publications were retrieved from PubMed:



Publications Link

Research Summary

My research investigates how fasting protects against proteostasis defects induced by hypoxia. More specifically, my work shows that fasting reduces the number of protein aggregates accrued during hypoxia, slows the accelerated paralysis rates associated with these aggregates, and also reduces the long-term defects in proteostasis that are induced by hypoxic insults. I’m investigating the nutrient-sensor AMP-activated protein kinase (AMPK) with the overarching goal of understanding how this kinase is differentially regulating hypoxia-induced protein aggregation in fed and fasted conditions.

Lab Information

Advisor: Dana Miller