Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Fasting protects against proteostasis defects induced by hypoxia
The following publications were retrieved from PubMed:
Iranon NN, Miller DL.
Front Genet. 2012; (3)257
My research investigates how fasting protects against proteostasis defects induced by hypoxia. More specifically, my work shows that fasting reduces the number of protein aggregates accrued during hypoxia, slows the accelerated paralysis rates associated with these aggregates, and also reduces the long-term defects in proteostasis that are induced by hypoxic insults. I’m investigating the nutrient-sensor AMP-activated protein kinase (AMPK) with the overarching goal of understanding how this kinase is differentially regulating hypoxia-induced protein aggregation in fed and fasted conditions.