student

Scott Best

srbest@uw.edu

Fred Hutch

Human Biology

Cancer Biology

Microbiology, Infection & Immunity

Entry Quarter: Autumn 2019

Current Position

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_614e0327af36674948003c48&retmode=json
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Publications

The following publications were retrieved from PubMed:

Proapoptotic and immunomodulatory effects of SYK inhibitor entospletinib in combination with obinutuzumab in patients with chronic lymphocytic leukaemia.

Lam V, Best S, Kittai A, Orand K, Spurgeon SE, Liu T, Danilov AV.

Br J Clin Pharmacol. 2021 Jun 30;

What a city eats: Examining the dietary preferences of families living in communities at high risk for food insecurity.

Cummer E, Loyola Amador C, Montez K, Skelton JA, Ramirez B, Best S, Zimmer R, Palakshappa D.

J Clin Transl Sci. 2020 Oct 19; 1(5)e55

Entospletinib and obinutuzumab in patients with relapsed/refractory chronic lymphocytic leukemia and B-cell malignancies.

Kittai AS, Best S, Thurlow B, Lam V, Hashiguchi T, Goodyear S, Persky DO, Okada C, Park B, Spurgeon SE, Danilov AV.

Haematologica. 2021 Jul 1; 7(106)2022-2025

Immunomodulatory effects of pevonedistat, a NEDD8-activating enzyme inhibitor, in chronic lymphocytic leukemia-derived T cells.

Best S, Lam V, Liu T, Bruss N, Kittai A, Danilova OV, Murray S, Berger A, Pennock ND, Lind EF, Danilov AV.

Leukemia. 2021 Jan; 1(35)156-168

Cyclin-Dependent Kinase-9 Is a Therapeutic Target in MYC-Expressing Diffuse Large B-Cell Lymphoma.

Hashiguchi T, Bruss N, Best S, Lam V, Danilova O, Paiva CJ, Wolf J, Gilbert EW, Okada CY, Kaur P, Drew L, Cidado J, Hurlin P, Danilov AV.

Mol Cancer Ther. 2019 Sep; 9(18)1520-1532



Publications Link

Research Summary

I focus on investigating mechanisms of chemotherapy resistance in small cell lung cancer (SCLC). Specifically, am using CRISPR/Cas9 technology to interrogate how specific loss-of-function mutations drive in-vivo cisplatin/etoposide chemoresistance in SCLC patient-derived xenograft (PDX) models.

Lab Information

Advisor: David MacPherson