student

Anja Ollodart

anjao@uw.edu
Entry Quarter: Autumn 2015
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_6038983bcef77a0c8008909a&retmode=json
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Publications

The following publications were retrieved from PubMed:

Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of Saccharomyces cerevisiae.

Sanchez JC, Ollodart A, Large CRL, Clough C, Alvino GM, Tsuchiya M, Crane M, Kwan EX, Kaeberlein M, Dunham MJ, Raghuraman MK, Brewer BJ.

Genetics. 2019 Sep; 1(213)229-249

Cooperation between distinct viral variants promotes growth of H3N2 influenza in cell culture.

Xue KS, Hooper KA, Ollodart AR, Dingens AS, Bloom JD.

Elife. 2016 Mar 15; (5)e13974

Mycobacterium tuberculosis supports protein tyrosine phosphorylation.

Kusebauch U, Ortega C, Ollodart A, Rogers RS, Sherman DR, Moritz RL, Grundner C.

Proc Natl Acad Sci U S A. 2014 Jun 24; 25(111)9265-70

Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch.

Ortega C, Liao R, Anderson LN, Rustad T, Ollodart AR, Wright AT, Sherman DR, Grundner C.

PLoS Biol. 2014 Jan; 1(12)e1001746

Mycobacterium tuberculosis Rv2179c protein establishes a new exoribonuclease family with broad phylogenetic distribution.

Abendroth J, Ollodart A, Andrews ES, Myler PJ, Staker BL, Edwards TE, Arcus VL, Grundner C.

J Biol Chem. 2014 Jan 24; 4(289)2139-47

Research Summary

My project focuses on developing a high-throughput and multiplexed way of determining mutation rate of genetically diverse microbial organisms using continuous culture. The first application of this method is to do a screen of variants in the DNA Mismatch repair pathway in yeast. Variants within this pathway are responsible for Lynch syndrome – a predisposition to a variety of cancers including colon cancer. A first pass at their functionality in yeast will allow a more focused view on potentially pathogenic variants of this pathway.

Lab Information

Advisor: Maitreya Dunham