Genetics, Genomics & Evolution
The following publications were retrieved from PubMed:
Sanchez JC, Ollodart A, Large CRL, Clough C, Alvino GM, Tsuchiya M, Crane M, Kwan EX, Kaeberlein M, Dunham MJ, Raghuraman MK, Brewer BJ.
Genetics. 2019 Sep; 1(213)229-249
Xue KS, Hooper KA, Ollodart AR, Dingens AS, Bloom JD.
Elife. 2016 Mar 15; (5)e13974
Kusebauch U, Ortega C, Ollodart A, Rogers RS, Sherman DR, Moritz RL, Grundner C.
Proc Natl Acad Sci U S A. 2014 Jun 24; 25(111)9265-70
Ortega C, Liao R, Anderson LN, Rustad T, Ollodart AR, Wright AT, Sherman DR, Grundner C.
PLoS Biol. 2014 Jan; 1(12)e1001746
Abendroth J, Ollodart A, Andrews ES, Myler PJ, Staker BL, Edwards TE, Arcus VL, Grundner C.
J Biol Chem. 2014 Jan 24; 4(289)2139-47
Ansong C, Ortega C, Payne SH, Haft DH, Chauvignè-Hines LM, Lewis MP, Ollodart AR, Purvine SO, Shukla AK, Fortuin S, Smith RD, Adkins JN, Grundner C, Wright AT.
Chem Biol. 2013 Jan 24; 1(20)123-33
My project focuses on developing a high-throughput and multiplexed way of determining mutation rate of genetically diverse microbial organisms using continuous culture. The first application of this method is to do a screen of variants in the DNA Mismatch repair pathway in yeast. Variants within this pathway are responsible for Lynch syndrome – a predisposition to a variety of cancers including colon cancer. A first pass at their functionality in yeast will allow a more focused view on potentially pathogenic variants of this pathway.