student

Tina Gall

Microbiology, Infection & Immunity

Entry Quarter: Summer 2013

Defining mechanisms of disease initiation through analysis of Helicobacter pylori interactions with gastric microbial communities and the host

Defense date: 05/31/2018
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Publications

The following publications were retrieved from PubMed:

Bacterial Composition of the Human Upper Gastrointestinal Tract Microbiome Is Dynamic and Associated with Genomic Instability in a Barrett's Esophagus Cohort.

Gall A, Fero J, McCoy C, Claywell BC, Sanchez CA, Blount PL, Li X, Vaughan TL, Matsen FA, Reid BJ, Salama NR.

PLoS One. 2015; 6(10)e0129055

Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.

Gall A, Treuting P, Elkon KB, Loo YM, Gale M Jr, Barber GN, Stetson DB.

Immunity. 2012 Jan 27; 1(36)120-31

Systemic effector and regulatory immune responses to chlamydial antigens in trachomatous trichiasis.

Gall A, Horowitz A, Joof H, Natividad A, Tetteh K, Riley E, Bailey RL, Mabey DC, Holland MJ.

Front Microbiol. 2011; (2)10

Pathway-focused arrays reveal increased matrix metalloproteinase-7 (matrilysin) transcription in trachomatous trichiasis.

Holland MJ, Jeffries D, Pattison M, Korr G, Gall A, Joof H, Manjang A, Burton MJ, Mabey DC, Bailey RL.

Invest Ophthalmol Vis Sci. 2010 Aug; 8(51)3893-902

Research Summary

I am interested in understanding how the gastric pathogen, Helicobacter pylori , interacts with its host. My projects are focused on elucidating the cellular and molecular mechanisms by which H. pylori triggers an innate immune response in gastric epithelial cells through the intracellular delivery of bacterial virulence factors into the host cell. Additionally, I am developing new tools for studying this host-pathogen interaction through the use of gastric organoid cell culture.

Lab Information

Advisor: Nina Salama