student

Brittany Whitley

whitleyb@uw.edu

University of Washington

Biochemistry

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Entry Quarter: Autumn 2014

Characterizing the molecular mechanisms that maintain balanced mitochondrial fusion and division in healthy and diseased cells

Defense date: 08/05/2019
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_614ddfb82f176f30ae239655&retmode=json
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Publications

The following publications were retrieved from PubMed:

Noncoding Microdeletion in Mouse Hgf Disrupts Neural Crest Migration into the Stria Vascularis, Reduces the Endocochlear Potential, and Suggests the Neuropathology for Human Nonsyndromic Deafness DFNB39.

Morell RJ, Olszewski R, Tona R, Leitess S, Wafa TT, Taukulis I, Schultz JM, Thomason EJ, Richards K, Whitley BN, Hill C, Saunders T, Starost MF, Fitzgerald T, Wilson E, Ohyama T, Friedman TB, Hoa M.

J Neurosci. 2020 Apr 8; 15(40)2976-2992

Mitochondrial dynamics and their potential as a therapeutic target.

Whitley BN, Engelhart EA, Hoppins S.

Mitochondrion. 2019 Nov; (49)269-283

Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2.

Sloat SR, Whitley BN, Engelhart EA, Hoppins S.

Mol Biol Cell. 2019 Aug 1; 17(30)2309-2319

Aberrant Drp1-mediated mitochondrial division presents in humans with variable outcomes.

Whitley BN, Lam C, Cui H, Haude K, Bai R, Escobar L, Hamilton A, Brady L, Tarnopolsky MA, Dengle L, Picker J, Lincoln S, Lackner LL, Glass IA, Hoppins S.

Hum Mol Genet. 2018 Nov 1; 21(27)3710-3719

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.

Davis MY, Trinh K, Thomas RE, Yu S, Germanos AA, Whitley BN, Sardi SP, Montine TJ, Pallanck LJ.

PLoS Genet. 2016 Mar; 3(12)e1005944

Research Summary

I study regulation of the mitochondrial outer membrane fusion proteins, Mfn1 and Mfn2.

Lab Information

Advisor: Suzanne Hoppins