student

Adam Dingens

adingens@uw.edu

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Entry Quarter: Autumn 2013

Complete mapping of HIV-1 escape from broadly neutralizing antibodies, vaccines, and drugs

Defense date: 01/07/2019
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Publications

The following publications were retrieved from PubMed:

Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5.

Roop JI, Cassidy NA, Dingens AS, Bloom JD, Overbaugh J.

Viruses. 2020 Feb 21; 2(12)

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody.

Schommers P, Gruell H, Abernathy ME, Tran MK, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MM, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fätkenheuer G, Seaman MS, Bloom JD, Bjorkman PJ, Klein F.

Cell. 2020 Feb 6; 3(180)471-489.e22

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.

Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schön A, Todd JP, Wang S, Wei H, Wu W, NISC Comparative Sequencing Program., Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR.

Cell. 2019 Jul 25; 3(178)567-584.e19

Massively Parallel Profiling of HIV-1 Resistance to the Fusion Inhibitor Enfuvirtide.

Dingens AS, Arenz D, Overbaugh J, Bloom JD.

Viruses. 2019 May 15; 5(11)

Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features.

Magaret CA, Benkeser DC, Williamson BD, Borate BR, Carpp LN, Georgiev IS, Setliff I, Dingens AS, Simon N, Carone M, Simpkins C, Montefiori D, Alter G, Yu WH, Juraska M, Edlefsen PT, Karuna S, Mgodi NM, Edugupanti S, Gilbert PB.

PLoS Comput Biol. 2019 Apr; 4(15)e1006952

Research Summary

I am developing new approaches to comprehensively map viral escape from anti-HIV antibodies, and using such approaches to interrogate Env function and evolution.

Lab Information

Advisor: Julie Overbaugh
Co-Advisor: Jesse Bloom