Kristen Mittelsteadt

Benaroya Research Institute, 


Cell Signaling & Cell/Environment Interactions

Gene Expression, Cell Cycle & Chromosome Biology

Microbiology, Infection & Immunity (Area Director)

Entry Quarter: Autumn 2014

Lab Information

Advisor: Daniel Campbell
Box: 1201 9th Ave. Seattle, WA 98101


Lung pericyte-like cells are functional interstitial immune sentinel cells.

Hung CF, Mittelsteadt KL, Brauer R, McKinney BL, Hallstrand TS, Parks WC, Chen P, Schnapp LM, Liles WC, Duffield JS, Altemeier WA.

Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L556-L567. doi: 10.1152/ajplung.00349.2016. Epub 2017 Feb 10.

Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury.

Leaf IA, Nakagawa S, Johnson BG, Cha JJ, Mittelsteadt K, Guckian KM, Gomez IG, Altemeier WA, Duffield JS.

J Clin Invest. 2017 Jan 3;127(1):321-334. doi: 10.1172/JCI87532. Epub 2016 Nov 21.

Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis.

Hung C, Linn G, Chow YH, Kobayashi A, Mittelsteadt K, Altemeier WA, Gharib SA, Schnapp LM, Duffield JS.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):820-30. doi: 10.1164/rccm.201212-2297OC.

TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury.

Campanholle G, Mittelsteadt K, Nakagawa S, Kobayashi A, Lin SL, Gharib SA, Heinecke JW, Hamerman JA, Altemeier WA, Duffield JS.

PLoS One. 2013 Jul 3;8(7):e68640. doi: 10.1371/journal.pone.0068640. Print 2013.

Lipopolysaccharide-induced lung injury is independent of serum vitamin D concentration.

Klaff LS, Gill SE, Wisse BE, Mittelsteadt K, Matute-Bello G, Chen P, Altemeier WA.

PLoS One. 2012;7(11):e49076. doi: 10.1371/journal.pone.0049076. Epub 2012 Nov 19.

Research Summary

My research is aimed at defining key signaling pathways that control regulatory T cell development, maintenance, and function in the context of infection and autoimmunity.