Michelle Hays
mhays@uw.eduFred Hutchinson/ University of Washington,
Molecular and Cellular Biology
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution (Area Director)
Microbiology, Infection & Immunity
Lab Information
Publications
Cromie GA, Tan Z, Hays M, Sirr A, Jeffery EW, Dudley AM.
G3 (Bethesda). 2017 Aug 7;7(8):2845-2854. doi: 10.1534/g3.117.042440.
- PMID:
- 28673928
Dissecting Gene Expression Changes Accompanying a Ploidy-Based Phenotypic Switch.
Cromie GA, Tan Z, Hays M, Jeffery EW, Dudley AM.
G3 (Bethesda). 2017 Jan 5;7(1):233-246. doi: 10.1534/g3.116.036160.
- PMID:
- 27836908
Independent Origins of Yeast Associated with Coffee and Cacao Fermentation.
Ludlow CL, Cromie GA, Garmendia-Torres C, Sirr A, Hays M, Field C, Jeffery EW, Fay JC, Dudley AM.
Curr Biol. 2016 Apr 4;26(7):965-71. doi: 10.1016/j.cub.2016.02.012. Epub 2016 Mar 24.
- PMID:
- 27020745
Cary GA, Yoon SH, Torres CG, Wang K, Hays M, Ludlow C, Goodlett DR, Dudley AM.
Yeast. 2014 May;31(5):167-78. doi: 10.1002/yea.3007. Epub 2014 Mar 19.
- PMID:
- 24610064
Aneuploidy underlies a multicellular phenotypic switch.
Tan Z, Hays M, Cromie GA, Jeffery EW, Scott AC, Ahyong V, Sirr A, Skupin A, Dudley AM.
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12367-72. doi: 10.1073/pnas.1301047110. Epub 2013 Jun 28.
- PMID:
- 23812752
High-throughput tetrad analysis.
Ludlow CL, Scott AC, Cromie GA, Jeffery EW, Sirr A, May P, Lin J, Gilbert TL, Hays M, Dudley AM.
Nat Methods. 2013 Jul;10(7):671-5. doi: 10.1038/nmeth.2479. Epub 2013 May 12.
- PMID:
- 23666411
Use of pleiotropy to model genetic interactions in a population.
Carter GW, Hays M, Sherman A, Galitski T.
PLoS Genet. 2012;8(10):e1003010. doi: 10.1371/journal.pgen.1003010. Epub 2012 Oct 11.
- PMID:
- 23071457
Predicting the effects of copy-number variation in double and triple mutant combinations.
Carter GW, Hays M, Li S, Galitski T.
Pac Symp Biocomput. 2012:19-30.
- PMID:
- 22174259
Research Summary
Selfish genetic elements exploit host cell machinery for their own reproduction, hurting host fitness in the process. How do host cells evolve to defend themselves against these genetic parasites? The selfish 2-micron plasmid is one example of a selfish genetic element found in many budding yeasts. The plasmid must hijack host cellular machinery to replicate and segregate its genome, which confers a fitness cost to the host. The genetic tractability of the 2- micron and budding yeast make this an ideal system for exploring: 1) how a host and parasite interact 2) through what means host cells can evolve to fight genetic parasites and 3) if these solutions to combating plasmids are recurrently evolving in multiple lineages.