Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution (Area Director)
Microbiology, Infection & Immunity
Host determinants of 2-micron stability in budding yeast
The following publications were retrieved from PubMed:
Intosalmi J, Scott AC, Hays M, Flann N, Yli-Harja O, Lähdesmäki H, Dudley AM, Skupin A.
BMC Mol Cell Biol. 2019 Dec 19; 1(20)59
Cromie GA, Tan Z, Hays M, Sirr A, Jeffery EW, Dudley AM.
G3 (Bethesda). 2017 Aug 7; 8(7)2845-2854
Cromie GA, Tan Z, Hays M, Jeffery EW, Dudley AM.
G3 (Bethesda). 2017 Jan 5; 1(7)233-246
Ludlow CL, Cromie GA, Garmendia-Torres C, Sirr A, Hays M, Field C, Jeffery EW, Fay JC, Dudley AM.
Curr Biol. 2016 Apr 4; 7(26)965-71
Cary GA, Yoon SH, Torres CG, Wang K, Hays M, Ludlow C, Goodlett DR, Dudley AM.
Yeast. 2014 May; 5(31)167-78
Tan Z, Hays M, Cromie GA, Jeffery EW, Scott AC, Ahyong V, Sirr A, Skupin A, Dudley AM.
Proc Natl Acad Sci U S A. 2013 Jul 23; 30(110)12367-72
Ludlow CL, Scott AC, Cromie GA, Jeffery EW, Sirr A, May P, Lin J, Gilbert TL, Hays M, Dudley AM.
Nat Methods. 2013 Jul; 7(10)671-5
Carter GW, Hays M, Sherman A, Galitski T.
PLoS Genet. 2012; 10(8)e1003010
Carter GW, Hays M, Li S, Galitski T.
Pac Symp Biocomput. 2012; 19-30
Selfish genetic elements exploit host cell machinery for their own reproduction, hurting host fitness in the process. How do host cells evolve to defend themselves against these genetic parasites? The selfish 2-micron plasmid is one example of a selfish genetic element found in many budding yeasts. The plasmid must hijack host cellular machinery to replicate and segregate its genome, which confers a fitness cost to the host. The genetic tractability of the 2- micron and budding yeast make this an ideal system for exploring: 1) how a host and parasite interact 2) through what means host cells can evolve to fight genetic parasites and 3) if these solutions to combating plasmids are recurrently evolving in multiple lineages.