student

Michelle Hays

mhays@uw.edu

Fred Hutchinson/ University of Washington, 

Molecular and Cellular Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution (Area Director)

Microbiology, Infection & Immunity

Entry Quarter: Autumn 2013

Lab Information

Advisor: Harmit Malik

Publications

Transcriptional Profiling of Biofilm Regulators Identified by an Overexpression Screen in Saccharomyces cerevisiae.

Cromie GA, Tan Z, Hays M, Sirr A, Jeffery EW, Dudley AM.

G3 (Bethesda). 2017 Aug 7;7(8):2845-2854. doi: 10.1534/g3.117.042440.

Dissecting Gene Expression Changes Accompanying a Ploidy-Based Phenotypic Switch.

Cromie GA, Tan Z, Hays M, Jeffery EW, Dudley AM.

G3 (Bethesda). 2017 Jan 5;7(1):233-246. doi: 10.1534/g3.116.036160.

Independent Origins of Yeast Associated with Coffee and Cacao Fermentation.

Ludlow CL, Cromie GA, Garmendia-Torres C, Sirr A, Hays M, Field C, Jeffery EW, Fay JC, Dudley AM.

Curr Biol. 2016 Apr 4;26(7):965-71. doi: 10.1016/j.cub.2016.02.012. Epub 2016 Mar 24.

Identification and characterization of a drug-sensitive strain enables puromycin-based translational assays in Saccharomyces cerevisiae.

Cary GA, Yoon SH, Torres CG, Wang K, Hays M, Ludlow C, Goodlett DR, Dudley AM.

Yeast. 2014 May;31(5):167-78. doi: 10.1002/yea.3007. Epub 2014 Mar 19.

Aneuploidy underlies a multicellular phenotypic switch.

Tan Z, Hays M, Cromie GA, Jeffery EW, Scott AC, Ahyong V, Sirr A, Skupin A, Dudley AM.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12367-72. doi: 10.1073/pnas.1301047110. Epub 2013 Jun 28.

Research Summary

Selfish genetic elements exploit host cell machinery for their own reproduction, hurting host fitness in the process. How do host cells evolve to defend themselves against these genetic parasites? The selfish 2-micron plasmid is one example of a selfish genetic element found in many budding yeasts. The plasmid must hijack host cellular machinery to replicate and segregate its genome, which confers a fitness cost to the host. The genetic tractability of the 2- micron and budding yeast make this an ideal system for exploring: 1) how a host and parasite interact 2) through what means host cells can evolve to fight genetic parasites and 3) if these solutions to combating plasmids are recurrently evolving in multiple lineages.