student

Kyle Hess (He/Him)

kylehess@uw.edu

University of Washington

Genome Sciences

Biophysical and Structural Biology

Cell Signaling & Cell/Environment Interactions

Entry Quarter: Autumn 2016
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Publications

The following publications were retrieved from PubMed:

Identification of phosphosites that alter protein thermal stability.

Smith IR, Hess KN, Bakhtina AA, Valente AS, Rodríguez-Mias RA, Villén J.

Nat Methods. 2021 Jul; 7(18)760-762

Origin and Evolution of the Human Bcl2-Associated Athanogene-1 (BAG-1).

Nguyen P, Hess K, Smulders L, Le D, Briseno C, Chavez CM, Nikolaidis N.

Int J Mol Sci. 2020 Dec 18; 24(21)

Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals.

Hess K, Oliverio R, Nguyen P, Le D, Ellis J, Kdeiss B, Ord S, Chalkia D, Nikolaidis N.

Sci Rep. 2018 Mar 23; 1(8)5082



Publications Link

Research Summary

Next-gen sequencing has unearthed millions of missense variants in the human population, the vast majority of which are variants of uncertain significance. My research aims to annotate the impact of these variants using mass spectrometry. By rapidly generating thousands of protein variants using mistranslation, I specifically seek to characterize how amino acid substitutions impact protein folding, stability, and function.

Lab Information

Advisor: Judit Villen