Kyle Hess (He/Him)email@example.com
University of Washington,
Biophysical and Structural Biology
Cell Signaling & Cell/Environment Interactions
The following publications were retrieved from PubMed:
Smith IR, Hess KN, Bakhtina AA, Valente AS, Rodríguez-Mias RA, Villén J.
Nat Methods. 2021 Jul; 7(18)760-762
Nguyen P, Hess K, Smulders L, Le D, Briseno C, Chavez CM, Nikolaidis N.
Int J Mol Sci. 2020 Dec 18; 24(21)
Hess K, Oliverio R, Nguyen P, Le D, Ellis J, Kdeiss B, Ord S, Chalkia D, Nikolaidis N.
Sci Rep. 2018 Mar 23; 1(8)5082
Next-gen sequencing has unearthed millions of missense variants in the human population, the vast majority of which are variants of uncertain significance. My research aims to annotate the impact of these variants using mass spectrometry. By rapidly generating thousands of protein variants using mistranslation, I specifically seek to characterize how amino acid substitutions impact protein folding, stability, and function.