student

Susana Orozco

slorozco@uw.edu

Cell Signaling & Cell/Environment Interactions

Microbiology, Infection & Immunity

Entry Quarter: Autumn 2012

RIPK3 activation: Necroptotic cell death and continued cytokine synthesis

Defense date: 05/23/2018
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Publications

The following publications were retrieved from PubMed:

RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity.

Orozco SL, Daniels BP, Yatim N, Messmer MN, Quarato G, Chen-Harris H, Cullen SP, Snyder AG, Ralli-Jain P, Frase S, Tait SWG, Green DR, Albert ML, Oberst A.

Cell Rep. 2019 Aug 27; 9(28)2275-2287.e5

Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity.

Snyder AG, Hubbard NW, Messmer MN, Kofman SB, Hagan CE, Orozco SL, Chiang K, Daniels BP, Baker D, Oberst A.

Sci Immunol. 2019 Jun 21; 36(4)

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.

Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, Roca A, Lopez J, Ichim G, Proïcs E, Rubio-Patiño C, Fort L, Yatim N, Woodham E, Orozco S, Taraborrelli L, Peltzer N, Lecis D, Machesky L, Walczak H, Albert ML, Milling S, Oberst A, Ricci JE, Ryan KM, Blyth K, Tait SWG.

Nat Cell Biol. 2017 Sep; 9(19)1116-1129

RIPK3 in cell death and inflammation: the good, the bad, and the ugly.

Orozco S, Oberst A.

Immunol Rev. 2017 May; 1(277)102-112

RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation.

Daniels BP, Snyder AG, Olsen TM, Orozco S, Oguin TH 3rd, Tait SWG, Martinez J, Gale M Jr, Loo YM, Oberst A.

Cell. 2017 Apr 6; 2(169)301-313.e11

Research Summary

In the Oberst Lab, we are interested in programmed cell death and immunity. My research focuses on how programmed necrosis, or “necroptosis,” leads to inflammation.

Lab Information

Advisor: Andrew Oberst
Box: 358059
206-221-2817