student

Andrew Bondesson

abondess@uw.edu

Fred Hutch

Human Biology

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Gene Expression, Cell Cycle & Chromosome Biology

Entry Quarter: Autumn 2016

Current Position

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Publications

The following publications were retrieved from PubMed:

Measuring Real-time Drug Response in Organotypic Tumor Tissue Slices.

Nishida-Aoki N, Bondesson AJ, Gujral TS.

J Vis Exp. 2020 May 2; 159

Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β.

Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL.

Cell. 2020 Feb 6; 3(180)490-501.e16

Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells.

Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL.

JCI Insight. 2018 Oct 18; 20(3)

Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter.

Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL.

J Biol Chem. 2015 Jun 5; 23(290)14717-28

Research Summary

My work focuses on discovering molecular mechanisms of Hippo pathway signaling and its implications on drug resistance, epithelial to mesenychymal transition and metastasis. I am employing a systems level approach making use of discovery-based, transcriptomic and phosphoproteomic/mass-spec data analysis, as well as hypothesis driven bench-top validation. I have also developed new techniques in tumor tissue slicing techniques, a medium throughput platform for drug development incorporating tumor microenvironments.

Lab Information

Advisor: Taran Gujral