faculty

Zhengui Xia

zxia@uw.edu

University of Washington, 

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Neuroscience

gene and environment interaction on adult neurogenesis and neurodegeneration

Faculty Contact Information

Building: HSB Room: F561C Box: 357234 Phone: 206-616-9433

Lab Information

Location: UW Building: HSB Room: F553 Box: 357234 Phone: 206-616-3634 Alt Phone: 2065436097 http://depts.washington.edu/xialab

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Winter
Permanent

Publications

Cadmium Exposure Impairs Cognition and Olfactory Memory in Male C57BL/6 Mice.

Wang H, Zhang L, Abel GM, Storm DR, Xia Z.

Toxicological sciences : an official journal of the Society of Toxicology. 2018; 161(1):87-102.

PubMed [journal]
PMID:
29029324
PMCID:
PMC5837361

Lead exposure in late adolescence through adulthood impairs short-term spatial memory and the neuronal differentiation of adult-born cells in C57BL/6 male mice.

Engstrom AK, Xia Z.

Neuroscience letters. 2017; 661:108-113. NIHMSID: NIHMS911546

PubMed [journal]
PMID:
28970130
PMCID:
PMC5671893

Correction to: Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice.

Engstrom AK, Snyder JM, Maeda N, Xia Z.

Molecular neurodegeneration. 2017; 12(1):81.

PubMed [journal]
PMID:
29100536
PMCID:
PMC5670524

Role of circadian rhythm and REM sleep for memory consolidation.

Xia Z, Storm D.

Neuroscience research. 2017; 118:13-20.

PubMed [journal]
PMID:
28434990

Cadmium impairs the survival and proliferation of cultured adult subventricular neural stem cells through activation of the JNK and p38 MAP kinases.

Wang H, Engstrom AK, Xia Z.

Toxicology. 2017; 380:30-37. NIHMSID: NIHMS853430

PubMed [journal]
PMID:
28163110
PMCID:
PMC5413202

Research Summary

It has been hypothesized that exposure to environmental factors may increase Alzheimer’s disease (AD) risk. However, there is a paucity of evidence supporting this hypothesis. The hippocampus is critical for cognition and especially vulnerable to damage at early stages of AD. We are using transgenic mouse models to test the hypotheses that a gene-environment interaction between environmental exposure and the presence of gene(s) with increased risk for AD impairs adult hippocampal neurogenesis and contributes to neuronal loss and cognitive decline in the initiation and progression of AD.