University of Washington,
Developmental Biology, Stem Cells & Aging
Gene Expression, Cell Cycle & Chromosome Biology
Molecular cell biology and mechanics of asymmetric cell division
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My lab is studying asymmetric cell division (ACD), a process that generates cellular diversity.
We are using fly neural stem cells as a model to study the molecular cell biology and mechanics of asymmetric stem cell division. Our current research focus is on (1) the molecular mechanisms underlying the establishment and maintenance of centrosome asymmetry and biased centrosome segregation. (2) Cell cortex dynamics and cleavage furrow positioning during asymmetric cell division. (3) Mechanical and biophysical mechanisms involved in ACD.