faculty

Hannele Ruohola-Baker

hannele@u.washington.edu

University of Washington, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Stem Cell Biology

Faculty Contact Information

Building: UW Medicine at South Lake Union, S580 Room: S584 Box: 358056 Phone: 206-543-8468 http://depts.washington.edu/taneli/

Lab Information

Location: Institute for Stem Cells and Regenerative Medicine Building: SLU South Room: S580 Box: 358056 Phone: 206-543-1710 http://depts.washington.edu/taneli/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation.

Friedman CE, Nguyen Q, Lukowski SW, Helfer A, Chiu HS, Miklas J, Levy S, Suo S, Han JJ, Osteil P, Peng G, Jing N, Baillie GJ, Senabouth A, Christ AN, Bruxner TJ, Murry CE, Wong ES, Ding J, Wang Y, Hudson J, Ruohola-Baker H, Bar-Joseph Z, Tam PPL, Powell JE, Palpant NJ.

Cell Stem Cell. 2018 Oct 4; 4(23)586-598.e8

Inducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewal.

Ferreccio A, Mathieu J, Detraux D, Somasundaram L, Cavanaugh C, Sopher B, Fischer K, Bello T, M Hussein A, Levy S, Cook S, Sidhu SB, Artoni F, Palpant NJ, Reinecke H, Wang Y, Paddison P, Murry C, Jayadev S, Ware C, Ruohola-Baker H.

Cell Cycle. 2018; 5(17)535-549

Loss of <i>foxo</i> rescues stem cell aging in <i>Drosophila</i> germ line.

Artoni F, Kreipke RE, Palmeira O, Dixon C, Goldberg Z, Ruohola-Baker H.

Elife. 2017 Sep 19; (6)

First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor.

Moody JD, Levy S, Mathieu J, Xing Y, Kim W, Dong C, Tempel W, Robitaille AM, Dang LT, Ferreccio A, Detraux D, Sidhu S, Zhu L, Carter L, Xu C, Valensisi C, Wang Y, Hawkins RD, Min J, Moon RT, Orkin SH, Baker D, Ruohola-Baker H.

Proc Natl Acad Sci U S A. 2017 Sep 19; 38(114)10125-10130

Metabolic remodeling during the loss and acquisition of pluripotency.

Mathieu J, Ruohola-Baker H.

Development. 2017 Feb 15; 4(144)541-551

Research Summary

The Ruohola-Baker laboratory studies the molecules and cellular properties that are required for stem cell states and their differentiation capacity, both in normal and pathological situations. The key questions are (1) how do metabolic determinants of stem cells regulate epigenetics, (2) what are the key microRNAs controlling cellular maturation and (3) what is the molecular mechanism of stem cell protection against apoptosis.