faculty

Arvind "Rasi" Subramaniam

rasi@fredhutch.org

Fred Hutch, 

Biophysical and Computational Biology

Computational Biology

Genetics, Genomics & Evolution

Regulation of mRNA translation in health and disease

Faculty Contact Information

Building: Weintraub Room: B3-155 Box: A3-015 Phone: 206-667-4679 Alt Phone: 206-667-4522

Lab Information

Location: Fred Hutch Building: Weintraub Room: B3-135 Box: A3-105 Phone: 206-667-4522 http://rasilab.org/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells.

Darnell AM, Subramaniam AR, O'Shea EK.

Molecular cell. 2018; 71(2):229-243.e11.

PubMed [journal]
PMID:
30029003

Kinetic modeling predicts a stimulatory role for ribosome collisions at elongation stall sites in bacteria.

Ferrin MA, Subramaniam AR.

eLife. 2017; 6.

PubMed [journal]
PMID:
28498106
PMCID:
PMC5446239

An integrated approach reveals regulatory controls on bacterial translation elongation.

Subramaniam AR, Zid BM, O'Shea EK.

Cell. 2014; 159(5):1200-1211. NIHMSID: NIHMS638990

PubMed [journal]
PMID:
25416955
PMCID:
PMC4243059

A serine sensor for multicellularity in a bacterium.

Subramaniam AR, Deloughery A, Bradshaw N, Chen Y, O'Shea E, Losick R, Chai Y.

eLife. 2013; 2:e01501.

PubMed [journal]
PMID:
24347549
PMCID:
PMC3862929

Environmental perturbations lift the degeneracy of the genetic code to regulate protein levels in bacteria.

Subramaniam AR, Pan T, Cluzel P.

Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(6):2419-24.

PubMed [journal]
PMID:
23277573
PMCID:
PMC3568297

Research Summary

Our lab studies regulation of mRNA translation using microbial and mammalian experimental models. We combine genomic and biochemical experimental approaches with computational analyses with the goal of formulating and testing kinetic models of mRNA translation.