faculty

Supriya Saha

sksaha@fredhutch.org

Fred Hutch, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution

Pathogenic mechanisms and novel therapeutics in liver cancer

Faculty Contact Information

Building: Hutchinson Room: C1-019 Box: C1-015 Phone: 206-667-4052 https://www.fredhutch.org/en/labs/profiles/saha-supriya.html

Lab Information

Location: Fred Hutchinson Cancer Research Center Building: Hutchinson Building Room: C1-187 Box: C1-187 Phone: 206-667-6209 Alt Phone: 206-667-7016 http://research.fhcrc.org/saha/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Research Summary

Our laboratory has three main areas of focus. We use genetically engineered mouse models to study how cancer-associated mutations and liver injury interact to drive the pathogenesis of liver cancer. We use unbiased high-throughput approaches to explore novel dependencies and therapeutics in specific genetic subsets of this disease. Finally, we use the serial acquisition of clinical specimens obtained through ongoing clinical trials to identify new mechanisms that confer resistance to targeted therapies in this highly lethal malignancy.