faculty

Andrew Hsieh

ahsieh@fredhutch.org

Fred Hutch, 

Biophysical and Computational Biology

Cancer Biology

Gene Expression, Cell Cycle & Chromosome Biology

POST-TRANSCRIPTIONAL GENE REGULATION IN CANCER

Faculty Contact Information

Building: Hutchinson Building Room: C2-167 Box: Mailstop C2-023 Phone: 206-667-5871 http://research.fhcrc.org/hsieh/en.html

Lab Information

Location: Fred Hutch Building: Hutchinson Building Room: C2-123 Box: C2-023 Phone: 206-667-5871 http://research.fhcrc.org/hsieh/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Mechanistic target of rapamycin (MTOR) protein expression in the tumor and its microenvironment correlates with more aggressive pathology at cystectomy.

Winters BR, Vakar-Lopez F, Brown L, Montgomery B, Seiler R, Black PC, Boormans JL, Dall Era M, Davincioni E, Douglas J, Gibb EA, van Rhijn BWG, van der Heijden MS, Hsieh AC, Wright JL, Lam HM.

Urologic oncology. 2018; 36(7):342.e7-342.e14.

PubMed [journal]
PMID:
29657089

A phase II study of the dual mTOR inhibitor MLN0128 in patients with metastatic castration resistant prostate cancer.

Graham L, Banda K, Torres A, Carver BS, Chen Y, Pisano K, Shelkey G, Curley T, Scher HI, Lotan TL, Hsieh AC, Rathkopf DE.

Investigational new drugs. 2018; 36(3):458-467. NIHMSID: NIHMS979738

PubMed [journal]
PMID:
29508246
PMCID:
PMC6050986

Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells.

Guzzi N, Cieśla M, Ngoc PCT, Lang S, Arora S, Dimitriou M, Pimková K, Sommarin MNE, Munita R, Lubas M, Lim Y, Okuyama K, Soneji S, Karlsson G, Hansson J, Jönsson G, Lund AH, Sigvardsson M, Hellström-Lindberg E, Hsieh AC, Bellodi C.

Cell. 2018; 173(5):1204-1216.e26.

PubMed [journal]
PMID:
29628141

Development of a stress response therapy targeting aggressive prostate cancer.

Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D.

Science translational medicine. 2018; 10(439). NIHMSID: NIHMS969586

PubMed [journal]
PMID:
29720449
PMCID:
PMC6045425

Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.

Bluemn EG, Coleman IM, Lucas JM, Coleman RT, Hernandez-Lopez S, Tharakan R, Bianchi-Frias D, Dumpit RF, Kaipainen A, Corella AN, Yang YC, Nyquist MD, Mostaghel E, Hsieh AC, Zhang X, Corey E, Brown LG, Nguyen HM, Pienta K, Ittmann M, Schweizer M, True LD, Wise D, Rennie PS, Vessella RL, Morrissey C, Nelson PS.

Cancer cell. 2017; 32(4):474-489.e6. NIHMSID: NIHMS905679

PubMed [journal]
PMID:
29017058
PMCID:
PMC5750052

Research Summary

Historically, cancer research has focused on alterations at the DNA and RNA levels as drivers of disease pathogenesis. However, there is an emerging realization that cancers often hijack the translational machinery to rewire gene expression networks towards transformation, metastasis, and drug resistance. The goal of our lab is to understand how deregulation of protein synthesis control determines the fate of epithelial cells in the multi-step process of cancer evolution. We aim to merge our fundamental discoveries in translational control biology with the clinical needs of cancer patients.