Gene Expression, Cell Cycle & Chromosome Biology
Nuclear Envelope Dynamics and Diseases
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We are at the beginning of redefining the nuclear envelope as a dynamic structure and determining how defects in nuclear envelope stability impact cell function. My lab will use a combination of cell biology, biochemistry, and genomics tools to address the following questions: 1) What are the mechanisms that drive nuclear envelope remodeling and dynamics? and 2) What are the consequences of losing nucleus compartmentalization at the cellular level and how does this contribute to cancer and laminopathy diseases?