faculty

Emily Hatch

ehatch@fredhutch.org
Assistant Professor

Fred Hutch

Basic Sciences

Cancer Biology

Gene Expression, Cell Cycle & Chromosome Biology

Nuclear membrane dynamics in mammalian cells

Faculty Contact Information

Building: Weintraub Room: B2-155 Box: A2-025 Phone: 206-667-5116 Alt Phone: 206-667-5116

Research Summary

We are at the beginning of redefining the nuclear envelope as a dynamic structure and determining how defects in nuclear envelope stability impact cell function. My lab uses a combination of cell biology, biochemistry, and genomics tools to address the following questions: 1) What are the mechanisms that drive nuclear envelope remodeling and dynamics? and 2) What are the consequences of losing nucleus compartmentalization at the cellular level and how does this contribute to cancer progression?

DEI Statement

Increased diversity in race, ethnicity, sexual orientation, nationality, gender, along with a commitment to accessibility are critical to enrich and accelerate the work being done in our lab and our scientific community. Along with her team, Dr. Hatch is committed to affirming and protecting the rights of everyone in the lab to a safe and supportive work environment. As part of this commitment, Dr. Hatch believes in mentoring lab members to achieve their best work and their unique professional goals, in addition to furthering scientific progress in the lab.

Training Summary

2019: University of Wisconsin CIMER training on Optimizing Research Mentoring Relationships: practical training for effective mentoring including aligning expectations, fostering independence, and promoting diversity.

2020: University of Wisconsin CIMER training on Culturally Aware Mentoring: explored how one’s cultural heritage impacts mentoring

2021: AAMC’s Transforming Conflict into Collaboration workshop: practical training for having difficult conversations and resolving conflict.

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Publications

The following publications were retrieved from PubMed:

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer.

Vichas A, Riley AK, Nkinsi NT, Kamlapurkar S, Parrish PCR, Lo A, Duke F, Chen J, Fung I, Watson J, Rees M, Gabel AM, Thomas JD, Bradley RK, Lee JK, Hatch EM, Baine MK, Rekhtman N, Ladanyi M, Piccioni F, Berger AH.

Nat Commun. 2021 Aug 9; 1(12)4789

Genome instability from nuclear catastrophe and DNA damage.

Mammel AE, Hatch EM.

Semin Cell Dev Biol. 2021 Apr 7;

Nuclear Membrane Rupture and Its Consequences.

Maciejowski J, Hatch EM.

Annu Rev Cell Dev Biol. 2020 Oct 6; (36)85-114

High-throughput, microscope-based sorting to dissect cellular heterogeneity.

Hasle N, Cooke A, Srivatsan S, Huang H, Stephany JJ, Krieger Z, Jackson D, Tang W, Pendyala S, Monnat RJ Jr, Trapnell C, Hatch EM, Fowler DM.

Mol Syst Biol. 2020 Jun; 6(16)e9442

BAF facilitates interphase nuclear membrane repair through recruitment of nuclear transmembrane proteins.

Young AM, Gunn AL, Hatch EM.

Mol Biol Cell. 2020 Jul 15; 15(31)1551-1560



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Lab Information

Location: Fred Hutchinson Cancer Research Center
Building: Weintraub
Room: B2-135
Box: A2-025
Phone: 206-667-4436
http://research.fhcrc.org/hatch/en.html