faculty

Michael Ailion

mailion@uw.edu

Associate Professor

University of Washington

Biochemistry

Cell Signaling & Cell/Environment Interactions

Neuroscience

Mechanisms of neuromodulation and speciation genetics

Faculty Contact Information

Building: Health Sciences Building Room: J341 Box: 357350 Phone: 206-685-0111 http://depts.washington.edu/ailion/

Research Summary

My lab has two major projects. (1) We study how neurons and endocrine cells make a unique organelle, the dense-core vesicle, that stores and releases peptide hormones such as insulin. (2) We study the genetics of hybrid incompatibility in C. elegans and related nematodes, aiming to identify genes that lead to speciation and to understand their molecular mechanisms.

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Publications

The following publications were retrieved from PubMed:

Recurrent but Short-Lived Duplications of Centromeric Proteins in Holocentric Caenorhabditis Species.

Caro L, Raman P, Steiner FA, Ailion M, Malik HS.

Mol Biol Evol. 2022 Oct 7; 10(39)

Local adaptation and spatiotemporal patterns of genetic diversity revealed by repeated sampling of Caenorhabditis elegans across the Hawaiian Islands.

Crombie TA, Battlay P, Tanny RE, Evans KS, Buchanan CM, Cook DE, Dilks CM, Stinson LA, Zdraljevic S, Zhang G, Roberto NM, Lee D, Ailion M, Hodgins KA, Andersen EC.

Mol Ecol. 2022 Apr; 8(31)2327-2347

Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in C. elegans.

Xu Y, Zhang L, Liu Y, Topalidou I, Hassinan C, Ailion M, Zhao Z, Wang T, Chen Z, Bai J.

iScience. 2021 Apr 23; 4(24)102247

Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin.

LaBella ML, Hujber EJ, Moore KA, Rawson RL, Merrill SA, Allaire PD, Ailion M, Hollien J, Bastiani MJ, Jorgensen EM.

Dev Cell. 2020 Apr 6; 1(53)130

Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin.

LaBella ML, Hujber EJ, Moore KA, Rawson RL, Merrill SA, Allaire PD, Ailion M, Hollien J, Bastiani MJ, Jorgensen EM.

Dev Cell. 2020 Jan 6; 1(52)88-103.e18

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