faculty

Michael Ailion

mailion@uw.edu
Associate Professor

University of Washington

Biochemistry

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution

Neuroscience

Mechanisms of neuromodulation and speciation genetics

Faculty Contact Information

Building: Health Sciences Building Room: J341 Box: 357350 Phone: 206-685-0111 http://depts.washington.edu/ailion/

Research Summary

My lab has two major projects. (1) We study how neurons and endocrine cells make a unique organelle, the dense-core vesicle, that stores and releases peptide hormones such as insulin. (2) We study the genetics of hybrid incompatibility in C. elegans and related nematodes, aiming to identify genes that lead to speciation and to understand their molecular mechanisms.

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Publications

The following publications were retrieved from PubMed:

Dopamine negatively modulates the NCA ion channels in C. elegans.

Topalidou I, Cooper K, Pereira L, Ailion M.

PLoS Genet. 2017 Oct; 10(13)e1007032

Genetics: Master Regulator or Master of Disguise?

Ailion M, Malik HS.

Curr Biol. 2017 Sep 11; 17(27)R844-R847

The dense-core vesicle maturation protein CCCP-1 binds RAB-2 and membranes through its C-terminal domain.

Cattin-Ortolá J, Topalidou I, Dosey A, Merz AJ, Ailion M.

Traffic. 2017 Nov; 11(18)720-732

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