faculty

Michael Ailion

mailion@uw.edu

Associate Professor

University of Washington

Biochemistry

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution

Neuroscience

Mechanisms of neuromodulation and speciation genetics

Faculty Contact Information

Building: Health Sciences Building Room: J341 Box: 357350 Phone: 206-685-0111 http://depts.washington.edu/ailion/

Research Summary

My lab has two major projects. (1) We study how neurons and endocrine cells make a unique organelle, the dense-core vesicle, that stores and releases peptide hormones such as insulin. (2) We study the genetics of hybrid incompatibility in C. elegans and related nematodes, aiming to identify genes that lead to speciation and to understand their molecular mechanisms.

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Publications

The following publications were retrieved from PubMed:

Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin.

LaBella ML, Hujber EJ, Moore KA, Rawson RL, Merrill SA, Allaire PD, Ailion M, Hollien J, Bastiani MJ, Jorgensen EM.

Dev Cell. 2020 Apr 6; 1(53)130

Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin.

LaBella ML, Hujber EJ, Moore KA, Rawson RL, Merrill SA, Allaire PD, Ailion M, Hollien J, Bastiani MJ, Jorgensen EM.

Dev Cell. 2020 Jan 6; 1(52)88-103.e18

Hybridization promotes asexual reproduction in Caenorhabditis nematodes.

Lamelza P, Young JM, Noble LM, Caro L, Isakharov A, Palanisamy M, Rockman MV, Malik HS, Ailion M.

PLoS Genet. 2019 Dec; 12(15)e1008520

EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells.

Topalidou I, Cattin-Ortolá J, Hummer B, Asensio CS, Ailion M.

Mol Biol Cell. 2020 Jan 1; 1(31)59-79

Pristionchus nematodes occur frequently in diverse rotting vegetal substrates and are not exclusively necromenic, while Panagrellus redivivoides is found specifically in rotting fruits.

Félix MA, Ailion M, Hsu JC, Richaud A, Wang J.

PLoS One. 2018; 8(13)e0200851

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