Michael Ailion
mailion@uw.eduUniversity of Washington,
Cell Signaling & Cell/Environment Interactions
Genetics, Genomics & Evolution
Neuroscience
Mechanisms of neuromodulation and speciation genetics
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
The following publications were retrieved from PubMed:
Félix MA, Ailion M, Hsu JC, Richaud A, Wang J.
PLoS One. 2018; 8(13)e0200851
Coleman B, Topalidou I, Ailion M.
Genetics. 2018 Jun; 2(209)523-535
Dopamine negatively modulates the NCA ion channels in C. elegans.
Topalidou I, Cooper K, Pereira L, Ailion M.
PLoS Genet. 2017 Oct; 10(13)e1007032
Genetics: Master Regulator or Master of Disguise?
Ailion M, Malik HS.
Curr Biol. 2017 Sep 11; 17(27)R844-R847
Cattin-Ortolá J, Topalidou I, Dosey A, Merz AJ, Ailion M.
Traffic. 2017 Nov; 11(18)720-732
The SEK-1 p38 MAP Kinase Pathway Modulates Gq Signaling in <i>Caenorhabditis elegans</i>.
Hoyt JM, Wilson SK, Kasa M, Rise JS, Topalidou I, Ailion M.
G3 (Bethesda). 2017 Sep 7; 9(7)2979-2989
Topalidou I, Chen PA, Cooper K, Watanabe S, Jorgensen EM, Ailion M.
Genetics. 2017 May; 1(206)265-282
Cytoplasmic-Nuclear Incompatibility Between Wild Isolates of <i>Caenorhabditis nouraguensis</i>.
Lamelza P, Ailion M.
G3 (Bethesda). 2017 Mar 10; 3(7)823-834
The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles.
Topalidou I, Cattin-Ortolá J, Pappas AL, Cooper K, Merrihew GE, MacCoss MJ, Ailion M.
PLoS Genet. 2016 May; 5(12)e1006074
Paquin N, Murata Y, Froehlich A, Omura DT, Ailion M, Pender CL, Constantine-Paton M, Horvitz HR.
Curr Biol. 2016 Apr 4; 7(26)862-71
Hollopeter G, Lange JJ, Zhang Y, Vu TN, Gu M, Ailion M, Lambie EJ, Slaughter BD, Unruh JR, Florens L, Jorgensen EM.
Elife. 2014 Oct 10; (3)
Two Rab2 interactors regulate dense-core vesicle maturation.
Ailion M, Hannemann M, Dalton S, Pappas A, Watanabe S, Hegermann J, Liu Q, Han HF, Gu M, Goulding MQ, Sasidharan N, Schuske K, Hullett P, Eimer S, Jorgensen EM.
Neuron. 2014 Apr 2; 1(82)167-80
Improved Mos1-mediated transgenesis in C. elegans.
Frøkjær-Jensen C, Davis MW, Ailion M, Jorgensen EM.
Nat Methods. 2012 Jan 30; 2(9)117-8
Kiontke KC, Félix MA, Ailion M, Rockman MV, Braendle C, Pénigault JB, Fitch DH.
BMC Evol Biol. 2011 Nov 21; (11)339
Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes.
McGrath PT, Xu Y, Ailion M, Garrison JL, Butcher RA, Bargmann CI.
Nature. 2011 Aug 17; 7364(477)321-5
Seidel HS, Ailion M, Li J, van Oudenaarden A, Rockman MV, Kruglyak L.
PLoS Biol. 2011 Jul; 7(9)e1001115
Luo L, Hannemann M, Koenig S, Hegermann J, Ailion M, Cho MK, Sasidharan N, Zweckstetter M, Rensing SA, Eimer S.
Mol Biol Cell. 2011 Jul 15; 14(22)2564-78
Teixeira-Castro A, Ailion M, Jalles A, Brignull HR, Vilaça JL, Dias N, Rodrigues P, Oliveira JF, Neves-Carvalho A, Morimoto RI, Maciel P.
Hum Mol Genet. 2011 Aug 1; 15(20)2996-3009
Jafari G, Burghoorn J, Kawano T, Mathew M, Mörck C, Axäng C, Ailion M, Thomas JH, Culotti JG, Swoboda P, Pilon M.
Genetics. 2010 Nov; 3(186)969-82
Reiner DJ, Ailion M, Thomas JH, Meyer BJ.
Curr Biol. 2008 Aug 5; 15(18)1101-9
Ammonium-acetate is sensed by gustatory and olfactory neurons in Caenorhabditis elegans.
Frøkjaer-Jensen C, Ailion M, Lockery SR.
PLoS One. 2008 Jun 18; 6(3)e2467
Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans.
Williams SL, Lutz S, Charlie NK, Vettel C, Ailion M, Coco C, Tesmer JJ, Jorgensen EM, Wieland T, Miller KG.
Genes Dev. 2007 Nov 1; 21(21)2731-46
Genetic analysis of dauer formation in Caenorhabditis briggsae.
Inoue T, Ailion M, Poon S, Kim HK, Thomas JH, Sternberg PW.
Genetics. 2007 Oct; 2(177)809-18
Speese S, Petrie M, Schuske K, Ailion M, Ann K, Iwasaki K, Jorgensen EM, Martin TF.
J Neurosci. 2007 Jun 6; 23(27)6150-62
Rodrigues AJ, Coppola G, Santos C, Costa Mdo C, Ailion M, Sequeiros J, Geschwind DH, Maciel P.
FASEB J. 2007 Apr; 4(21)1126-36
Li J, Brown G, Ailion M, Lee S, Thomas JH.
Development. 2004 Nov; 22(131)5741-52
Ailion M, Thomas JH.
Genetics. 2003 Sep; 1(165)127-44
Dauer formation induced by high temperatures in Caenorhabditis elegans.
Ailion M, Thomas JH.
Genetics. 2000 Nov; 3(156)1047-67
Daniels SA, Ailion M, Thomas JH, Sengupta P.
Genetics. 2000 Sep; 1(156)123-41
Neurosecretory control of aging in Caenorhabditis elegans.
Ailion M, Inoue T, Weaver CI, Holdcraft RW, Thomas JH.
Proc Natl Acad Sci U S A. 1999 Jun 22; 13(96)7394-7
Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G.
Genes Dev. 1999 Jun 1; 11(13)1438-52
Ailion M, Roth JR.
J Bacteriol. 1997 Oct; 19(179)6084-91
Genetic characterization of the pdu operon: use of 1,2-propanediol in Salmonella typhimurium.
Walter D, Ailion M, Roth J.
J Bacteriol. 1997 Feb; 4(179)1013-22
Five promoters integrate control of the cob/pdu regulon in Salmonella typhimurium.
Chen P, Ailion M, Bobik T, Stormo G, Roth J.
J Bacteriol. 1995 Oct; 19(177)5401-10
Chen P, Ailion M, Weyand N, Roth J.
J Bacteriol. 1995 Mar; 6(177)1461-9
Ailion M, Bobik TA, Roth JR.
J Bacteriol. 1993 Nov; 22(175)7200-8
A single regulatory gene integrates control of vitamin B12 synthesis and propanediol degradation.
Bobik TA, Ailion M, Roth JR.
J Bacteriol. 1992 Apr; 7(174)2253-66
Research Summary
My lab has two projects. (1) We study how neurons and endocrine cells make a unique organelle, the dense-core vesicle, that stores and releases peptide hormones such as insulin. (2) We study the genetics of hybrid incompatibility in C. elegans and related nematodes, aiming to identify genes that lead to speciation and to understand their molecular mechanisms.