faculty

Matt Kaeberlein

kaeber@uw.edu

University of Washington, 

Developmental Biology, Stem Cells & Aging (Area Director)

Genetics, Genomics & Evolution

Basic and translational geroscience (biology of aging)

Faculty Contact Information

Building: Health Science Building Room: D-513 Box: 357470 Phone: 206-221-4849 Alt Phone: 206-221-3745 http://www.kaeberleinlab.org/

Lab Information

Location: University of Washington Building: Health Science Building Room: D-514 Box: 357470 Phone: 206-221-4849 Alt Phone: 2062214849 http://www.kaeberleinlab.org/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Winter
Permanent

Publications

Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes.

Lee MB, Dowsett IT, Carr DT, Wasko BM, Stanton SG, Chung MS, Ghodsian N, Bode A, Kiflezghi MG, Uppal PA, Grayden KA, Elala YC, Tang TT, Tran NHB, Tran THB, Diep AB, Hope M, Promislow DEL, Kennedy SR, Kaeberlein M, Herr AJ.

Proceedings of the National Academy of Sciences of the United States of America. 2019; 116(8):3062-3071.

PubMed [journal]
PMID:
30718408
PMCID:
PMC6386679

Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.

Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM.

Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(38):9586-9591.

PubMed [journal]
PMID:
30185560
PMCID:
PMC6156608

How healthy is the healthspan concept?

Kaeberlein M.

GeroScience. 2018; 40(4):361-364.

PubMed [journal]
PMID:
30084059
PMCID:
PMC6136295

Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans.

Burnaevskiy N, Chen S, Mailig M, Reynolds A, Karanth S, Mendenhall A, Van Gilst M, Kaeberlein M.

eLife. 2018; 7.

PubMed [journal]
PMID:
30070633
PMCID:
PMC6089596

The paths of mortality: how understanding the biology of aging can help explain systems behavior of single cells.

Crane MM, Kaeberlein M.

Current opinion in systems biology. 2018; 8:25-31. NIHMSID: NIHMS925979

PubMed [journal]
PMID:
29552673
PMCID:
PMC5851462

Research Summary

Age is the single greatest risk factor for nearly every major cause of morbidity and mortality in developed nations: Alzheimer’s disease, heart disease, most cancers, diabetes, kidney disease, etc. The Kaeberlein lab is interested in understanding the molecular mechanisms that drive the aging process and cause people to develop diseases and disabilities of aging. We hope to use this information to directly intervene in the aging process in order to promote healthy longevity.