faculty

Hannele Ruohola-Baker

hannele@u.washington.edu

University of Washington, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Stem Cell Biology

Faculty Contact Information

Building: UW Medicine at South Lake Union, S580 Room: S584 Box: 358056 Phone: 206-543-8468 http://depts.washington.edu/taneli/

Lab Information

Location: Institute for Stem Cells and Regenerative Medicine Building: SLU South Room: S580 Box: 358056 Phone: 206-543-1710 http://depts.washington.edu/taneli/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Enhancer Chromatin and 3D Genome Architecture Changes from Naive to Primed Human Embryonic Stem Cell States.

Battle SL, Doni Jayavelu N, Azad RN, Hesson J, Ahmed FN, Overbey EG, Zoller JA, Mathieu J, Ruohola-Baker H, Ware CB, Hawkins RD.

Stem Cell Reports. 2019 May 14; 5(12)1129-1144

Integrated epigenomic profiling reveals endogenous retrovirus reactivation in renal cell carcinoma.

Siebenthall KT, Miller CP, Vierstra JD, Mathieu J, Tretiakova M, Reynolds A, Sandstrom R, Rynes E, Haugen E, Johnson A, Nelson J, Bates D, Diegel M, Dunn D, Frerker M, Buckley M, Kaul R, Zheng Y, Himmelfarb J, Ruohola-Baker H, Akilesh S.

EBioMedicine. 2019 Mar; (41)427-442

Metabolism as an early predictor of DPSCs aging.

Macrin D, Alghadeer A, Zhao YT, Miklas JW, Hussein AM, Detraux D, Robitaille AM, Madan A, Moon RT, Wang Y, Devi A, Mathieu J, Ruohola-Baker H.

Sci Rep. 2019 Feb 18; 1(9)2195

Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency.

Mathieu J, Detraux D, Kuppers D, Wang Y, Cavanaugh C, Sidhu S, Levy S, Robitaille AM, Ferreccio A, Bottorff T, McAlister A, Somasundaram L, Artoni F, Battle S, Hawkins RD, Moon RT, Ware CB, Paddison PJ, Ruohola-Baker H.

Nat Commun. 2019 Feb 7; 1(10)632

Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation.

Friedman CE, Nguyen Q, Lukowski SW, Helfer A, Chiu HS, Miklas J, Levy S, Suo S, Han JJ, Osteil P, Peng G, Jing N, Baillie GJ, Senabouth A, Christ AN, Bruxner TJ, Murry CE, Wong ES, Ding J, Wang Y, Hudson J, Ruohola-Baker H, Bar-Joseph Z, Tam PPL, Powell JE, Palpant NJ.

Cell Stem Cell. 2018 Oct 4; 4(23)586-598.e8

Research Summary

The Ruohola-Baker laboratory studies the molecules and cellular properties that are required for stem cell states and their differentiation capacity, both in normal and pathological situations. The key questions are (1) how do metabolic determinants of stem cells regulate epigenetics, (2) what are the key microRNAs controlling cellular maturation and (3) what is the molecular mechanism of stem cell protection against apoptosis.