faculty

Hannele Ruohola-Baker

hannele@u.washington.edu
Professor

University of Washington

Biochemistry

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Stem Cell Biology

Faculty Contact Information

Building: UW Medicine at South Lake Union, S580 Room: S584 Box: 358056 Phone: 206-543-8468 http://depts.washington.edu/taneli/

Research Summary

The Ruohola-Baker laboratory studies the molecules and cellular properties that are required for stem cell states and their differentiation capacity, both in normal and pathological situations. The key questions are (1) how do metabolic determinants of stem cells regulate epigenetics, (2) what are the key microRNAs controlling cellular maturation and (3) what is the molecular mechanism of stem cell protection against apoptosis.

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Publications

The following publications were retrieved from PubMed:

TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes.

Miklas JW, Clark E, Levy S, Detraux D, Leonard A, Beussman K, Showalter MR, Smith AT, Hofsteen P, Yang X, Macadangdang J, Manninen T, Raftery D, Madan A, Suomalainen A, Kim DH, Murry CE, Fiehn O, Sniadecki NJ, Wang Y, Ruohola-Baker H.

Nat Commun. 2019 Oct 11; 1(10)4671

Fatty Acids Enhance the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells.

Yang X, Rodriguez ML, Leonard A, Sun L, Fischer KA, Wang Y, Ritterhoff J, Zhao L, Kolwicz SC Jr, Pabon L, Reinecke H, Sniadecki NJ, Tian R, Ruohola-Baker H, Xu H, Murry CE.

Stem Cell Reports. 2019 Oct 8; 4(13)657-668

Enhancer Chromatin and 3D Genome Architecture Changes from Naive to Primed Human Embryonic Stem Cell States.

Battle SL, Doni Jayavelu N, Azad RN, Hesson J, Ahmed FN, Overbey EG, Zoller JA, Mathieu J, Ruohola-Baker H, Ware CB, Hawkins RD.

Stem Cell Reports. 2019 May 14; 5(12)1129-1144

Integrated epigenomic profiling reveals endogenous retrovirus reactivation in renal cell carcinoma.

Siebenthall KT, Miller CP, Vierstra JD, Mathieu J, Tretiakova M, Reynolds A, Sandstrom R, Rynes E, Haugen E, Johnson A, Nelson J, Bates D, Diegel M, Dunn D, Frerker M, Buckley M, Kaul R, Zheng Y, Himmelfarb J, Ruohola-Baker H, Akilesh S.

EBioMedicine. 2019 Mar; (41)427-442

Metabolism as an early predictor of DPSCs aging.

Macrin D, Alghadeer A, Zhao YT, Miklas JW, Hussein AM, Detraux D, Robitaille AM, Madan A, Moon RT, Wang Y, Devi A, Mathieu J, Ruohola-Baker H.

Sci Rep. 2019 Feb 18; 1(9)2195

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Lab Information

Location: Institute for Stem Cells and Regenerative Medicine
Building: SLU South
Room: S580
Box: 358056
Phone: 206-543-1710
http://depts.washington.edu/taneli/