faculty

Hannele Ruohola-Baker

hannele@u.washington.edu

Professor

University of Washington

Biochemistry

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Stem Cell Biology

Faculty Contact Information

Building: UW Medicine at South Lake Union, S580 Room: S584 Box: 358056 Phone: 206-543-8468 http://depts.washington.edu/taneli/

Research Summary

The Ruohola-Baker laboratory studies the molecules and cellular properties that are required for stem cell states and their differentiation capacity, both in normal and pathological situations. The key questions are (1) how do metabolic determinants of stem cells regulate epigenetics, (2) what are the key microRNAs controlling cellular maturation and (3) what is the molecular mechanism of stem cell protection against apoptosis.

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Publications

The following publications were retrieved from PubMed:

Author Correction: TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes.

Miklas JW, Clark E, Levy S, Detraux D, Leonard A, Beussman K, Showalter MR, Smith AT, Hofsteen P, Yang X, Macadangdang J, Manninen T, Raftery D, Madan A, Suomalainen A, Kim DH, Murry CE, Fiehn O, Sniadecki NJ, Wang Y, Ruohola-Baker H.

Nat Commun. 2020 May 8; 1(11)2387

Epigenetic metabolites license stem cell states.

Somasundaram L, Levy S, Hussein AM, Ehnes DD, Mathieu J, Ruohola-Baker H.

Curr Top Dev Biol. 2020; (138)209-240

Germline stem cell aging in the Drosophila ovary.

Ishibashi JR, Taslim TH, Ruohola-Baker H.

Curr Opin Insect Sci. 2020 Feb; (37)57-62

Combinatorial metabolism drives the naive to primed pluripotent chromatin landscape.

Ehnes DD, Hussein AM, Ware CB, Mathieu J, Ruohola-Baker H.

Exp Cell Res. 2020 Apr 15; 2(389)111913

Metabolic Control over mTOR-Dependent Diapause-like State.

Hussein AM, Wang Y, Mathieu J, Margaretha L, Song C, Jones DC, Cavanaugh C, Miklas JW, Mahen E, Showalter MR, Ruzzo WL, Fiehn O, Ware CB, Blau CA, Ruohola-Baker H.

Dev Cell. 2020 Jan 27; 2(52)236-250.e7

Accepting Students For:

Rotation, Autumn

Rotation, Spring

Rotation, Summer

Rotation, Winter

Permanent

Lab Information

Location: Institute for Stem Cells and Regenerative Medicine
Building: SLU South
Room: S580
Box: 358056
Phone: 206-543-1710
http://depts.washington.edu/taneli/