Hannele Ruohola-Baker
hannele@u.washington.eduUniversity of Washington,
Cancer Biology
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Stem Cell Biology
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
The following publications were retrieved from PubMed:
Battle SL, Doni Jayavelu N, Azad RN, Hesson J, Ahmed FN, Overbey EG, Zoller JA, Mathieu J, Ruohola-Baker H, Ware CB, Hawkins RD.
Stem Cell Reports. 2019 May 14; 5(12)1129-1144
Integrated epigenomic profiling reveals endogenous retrovirus reactivation in renal cell carcinoma.
Siebenthall KT, Miller CP, Vierstra JD, Mathieu J, Tretiakova M, Reynolds A, Sandstrom R, Rynes E, Haugen E, Johnson A, Nelson J, Bates D, Diegel M, Dunn D, Frerker M, Buckley M, Kaul R, Zheng Y, Himmelfarb J, Ruohola-Baker H, Akilesh S.
EBioMedicine. 2019 Mar; (41)427-442
Metabolism as an early predictor of DPSCs aging.
Macrin D, Alghadeer A, Zhao YT, Miklas JW, Hussein AM, Detraux D, Robitaille AM, Madan A, Moon RT, Wang Y, Devi A, Mathieu J, Ruohola-Baker H.
Sci Rep. 2019 Feb 18; 1(9)2195
Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency.
Mathieu J, Detraux D, Kuppers D, Wang Y, Cavanaugh C, Sidhu S, Levy S, Robitaille AM, Ferreccio A, Bottorff T, McAlister A, Somasundaram L, Artoni F, Battle S, Hawkins RD, Moon RT, Ware CB, Paddison PJ, Ruohola-Baker H.
Nat Commun. 2019 Feb 7; 1(10)632
Friedman CE, Nguyen Q, Lukowski SW, Helfer A, Chiu HS, Miklas J, Levy S, Suo S, Han JJ, Osteil P, Peng G, Jing N, Baillie GJ, Senabouth A, Christ AN, Bruxner TJ, Murry CE, Wong ES, Ding J, Wang Y, Hudson J, Ruohola-Baker H, Bar-Joseph Z, Tam PPL, Powell JE, Palpant NJ.
Cell Stem Cell. 2018 Oct 4; 4(23)586-598.e8
Ferreccio A, Mathieu J, Detraux D, Somasundaram L, Cavanaugh C, Sopher B, Fischer K, Bello T, M Hussein A, Levy S, Cook S, Sidhu SB, Artoni F, Palpant NJ, Reinecke H, Wang Y, Paddison P, Murry C, Jayadev S, Ware C, Ruohola-Baker H.
Cell Cycle. 2018; 5(17)535-549
Loss of <i>foxo</i> rescues stem cell aging in <i>Drosophila</i> germ line.
Artoni F, Kreipke RE, Palmeira O, Dixon C, Goldberg Z, Ruohola-Baker H.
Elife. 2017 Sep 19; (6)
Moody JD, Levy S, Mathieu J, Xing Y, Kim W, Dong C, Tempel W, Robitaille AM, Dang LT, Ferreccio A, Detraux D, Sidhu S, Zhu L, Carter L, Xu C, Valensisi C, Wang Y, Hawkins RD, Min J, Moon RT, Orkin SH, Baker D, Ruohola-Baker H.
Proc Natl Acad Sci U S A. 2017 Sep 19; 38(114)10125-10130
Metabolic remodeling during the loss and acquisition of pluripotency.
Mathieu J, Ruohola-Baker H.
Development. 2017 Feb 15; 4(144)541-551
Brown K, Yang P, Salvador D, Kulikauskas R, Ruohola-Baker H, Robitaille AM, Chien AJ, Moon RT, Sherwood V.
Oncogene. 2017 Jun 1; 22(36)3119-3136
Drosophila melanogaster as a Model of Muscle Degeneration Disorders.
Kreipke RE, Kwon YV, Shcherbata HR, Ruohola-Baker H.
Curr Top Dev Biol. 2017; (121)83-109
Xu Z, Robitaille AM, Berndt JD, Davidson KC, Fischer KA, Mathieu J, Potter JC, Ruohola-Baker H, Moon RT.
Proc Natl Acad Sci U S A. 2016 Oct 18; 42(113)E6382-E6390
Mature Let-7 miRNAs fine tune expression of LIN28B in pluripotent human embryonic stem cells.
Rahkonen N, Stubb A, Malonzo M, Edelman S, Emani MR, Närvä E, Lähdesmäki H, Ruohola-Baker H, Lahesmaa R, Lund R.
Stem Cell Res. 2016 Nov; 3(17)498-503
Metabolic RemodeLIN of Pluripotency.
Mathieu J, Ruohola-Baker H.
Cell Stem Cell. 2016 Jul 7; 1(19)3-4
Metabolic remodeling in early development and cardiomyocyte maturation.
Ellen Kreipke R, Wang Y, Miklas JW, Mathieu J, Ruohola-Baker H.
Semin Cell Dev Biol. 2016 Apr; (52)84-92
Sperber H, Mathieu J, Wang Y, Ferreccio A, Hesson J, Xu Z, Fischer KA, Devi A, Detraux D, Gu H, Battle SL, Showalter M, Valensisi C, Bielas JH, Ericson NG, Margaretha L, Robitaille AM, Margineantu D, Fiehn O, Hockenbery D, Blau CA, Raftery D, Margolin AA, Hawkins RD, Moon RT, Ware CB, Ruohola-Baker H.
Nat Cell Biol. 2015 Dec; 12(17)1523-35
Kuppusamy KT, Jones DC, Sperber H, Madan A, Fischer KA, Rodriguez ML, Pabon L, Zhu WZ, Tulloch NL, Yang X, Sniadecki NJ, Laflamme MA, Ruzzo WL, Murry CE, Ruohola-Baker H.
Proc Natl Acad Sci U S A. 2015 May 26; 21(112)E2785-94
Tie-mediated signal from apoptotic cells protects stem cells in Drosophila melanogaster.
Xing Y, Su TT, Ruohola-Baker H.
Nat Commun. 2015 May 11; (6)7058
Yang X, Rodriguez M, Pabon L, Fischer KA, Reinecke H, Regnier M, Sniadecki NJ, Ruohola-Baker H, Murry CE.
J Mol Cell Cardiol. 2014 Jul; (72)296-304
miRNA sensitivity to Drosha levels correlates with pre-miRNA secondary structure.
Sperber H, Beem A, Shannon S, Jones R, Banik P, Chen Y, Ku S, Varani G, Yao S, Ruohola-Baker H.
RNA. 2014 May; 5(20)621-31
Mathieu J, Zhou W, Xing Y, Sperber H, Ferreccio A, Agoston Z, Kuppusamy KT, Moon RT, Ruohola-Baker H.
Cell Stem Cell. 2014 May 1; 5(14)592-605
Derivation of naive human embryonic stem cells.
Ware CB, Nelson AM, Mecham B, Hesson J, Zhou W, Jonlin EC, Jimenez-Caliani AJ, Deng X, Cavanaugh C, Cook S, Tesar PJ, Okada J, Margaretha L, Sperber H, Choi M, Blau CA, Treuting PM, Hawkins RD, Cirulli V, Ruohola-Baker H.
Proc Natl Acad Sci U S A. 2014 Mar 25; 12(111)4484-9
Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF, Childers MK.
Stem Cell Res. 2014 Mar; 2(12)467-80
Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy.
Nguyen-Tran DH, Hait NC, Sperber H, Qi J, Fischer K, Ieronimakis N, Pantoja M, Hays A, Allegood J, Reyes M, Spiegel S, Ruohola-Baker H.
Dis Model Mech. 2014 Jan; 1(7)41-54
Increased sphingosine-1-phosphate improves muscle regeneration in acutely injured mdx mice.
Ieronimakis N, Pantoja M, Hays AL, Dosey TL, Qi J, Fischer KA, Hoofnagle AN, Sadilek M, Chamberlain JS, Ruohola-Baker H, Reyes M.
Skelet Muscle. 2013 Aug 1; 1(3)20
Hypoxia induces re-entry of committed cells into pluripotency.
Mathieu J, Zhang Z, Nelson A, Lamba DA, Reh TA, Ware C, Ruohola-Baker H.
Stem Cells. 2013 Sep; 9(31)1737-48
Regulation of stem cell populations by microRNAs.
Mathieu J, Ruohola-Baker H.
Adv Exp Med Biol. 2013; (786)329-51
MicroRNA regulation and role in stem cell maintenance, cardiac differentiation and hypertrophy.
Kuppusamy KT, Sperber H, Ruohola-Baker H.
Curr Mol Med. 2013 Jun; 5(13)757-64
Use of somatic mutations to quantify random contributions to mouse development.
Zhou W, Tan Y, Anderson DJ, Crist EM, Ruohola-Baker H, Salipante SJ, Horwitz MS.
BMC Genomics. 2013 Jan 18; (14)39
Pantoja M, Ruohola-Baker H.
Rare Dis. 2013; (1)e24995
Genetic elevation of sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila.
Pantoja M, Fischer KA, Ieronimakis N, Reyes M, Ruohola-Baker H.
Development. 2013 Jan 1; 1(140)136-46
Zhou W, Choi M, Margineantu D, Margaretha L, Hesson J, Cavanaugh C, Blau CA, Horwitz MS, Hockenbery D, Ware C, Ruohola-Baker H.
EMBO J. 2012 May 2; 9(31)2103-16
Xing Y, Kurtz I, Thuparani M, Legard J, Ruohola-Baker H.
G3 (Bethesda). 2012 Mar; 3(2)343-51
Zhou W, Dosey TL, Biechele T, Moon RT, Horwitz MS, Ruohola-Baker H.
PLoS One. 2011; 11(6)e27460
HIF induces human embryonic stem cell markers in cancer cells.
Mathieu J, Zhang Z, Zhou W, Wang AJ, Heddleston JM, Pinna CM, Hubaud A, Stadler B, Choi M, Bar M, Tewari M, Liu A, Vessella R, Rostomily R, Born D, Horwitz M, Ware C, Blau CA, Cleary MA, Rich JN, Ruohola-Baker H.
Cancer Res. 2011 Jul 1; 13(71)4640-52
Mosqueira M, Willmann G, Ruohola-Baker H, Khurana TS.
PLoS One. 2010 Oct 20; 10(5)e13450
Vêncio EF, Pascal LE, Page LS, Denyer G, Wang AJ, Ruohola-Baker H, Zhang S, Wang K, Galas DJ, Liu AY.
J Cell Physiol. 2011 Jun; 6(226)1479-88
Assessing in vivo microRNA function in the germline stem cells of the Drosophila ovary.
Chan K, Ruohola-Baker H.
Methods Mol Biol. 2010; (650)201-12
Dystroglycan and mitochondrial ribosomal protein L34 regulate differentiation in the Drosophila eye.
Zhan Y, Melian NY, Pantoja M, Haines N, Ruohola-Baker H, Bourque CW, Rao Y, Carbonetto S.
PLoS One. 2010 May 5; 5(5)e10488
Characterization of microRNAs involved in embryonic stem cell states.
Stadler B, Ivanovska I, Mehta K, Song S, Nelson A, Tan Y, Mathieu J, Darby C, Blau CA, Ware C, Peters G, Miller DG, Shen L, Cleary MA, Ruohola-Baker H.
Stem Cells Dev. 2010 Jul; 7(19)935-50
microRNAs regulate human embryonic stem cell division.
Qi J, Yu JY, Shcherbata HR, Mathieu J, Wang AJ, Seal S, Zhou W, Stadler BM, Bourgin D, Wang L, Nelson A, Ware C, Raymond C, Lim LP, Magnus J, Ivanovska I, Diaz R, Ball A, Cleary MA, Ruohola-Baker H.
Cell Cycle. 2009 Nov 15; 22(8)3729-41
Yu JY, Reynolds SH, Hatfield SD, Shcherbata HR, Fischer KA, Ward EJ, Long D, Ding Y, Ruohola-Baker H.
Development. 2009 May; 9(136)1497-507
Yatsenko AS, Kucherenko MM, Pantoja M, Fischer KA, Madeoy J, Deng WM, Schneider M, Baumgartner S, Akey J, Shcherbata HR, Ruohola-Baker H.
BMC Dev Biol. 2009 Feb 27; (9)18
Bar M, Wyman SK, Fritz BR, Qi J, Garg KS, Parkin RK, Kroh EM, Bendoraite A, Mitchell PS, Nelson AM, Ruzzo WL, Ware C, Radich JP, Gentleman R, Ruohola-Baker H, Tewari M.
Stem Cells. 2008 Oct; 10(26)2496-505
Kucherenko MM, Pantoja M, Yatsenko AS, Shcherbata HR, Fischer KA, Maksymiv DV, Chernyk YI, Ruohola-Baker H.
PLoS One. 2008 Jun 11; 6(3)e2418
Shcherbata HR, Ward EJ, Fischer KA, Yu JY, Reynolds SH, Chen CH, Xu P, Hay BA, Ruohola-Baker H.
Cell Stem Cell. 2007 Dec 13; 6(1)698-709
microRNA and stem cell function.
Hatfield S, Ruohola-Baker H.
Cell Tissue Res. 2008 Jan; 1(331)57-66
Yatsenko AS, Gray EE, Shcherbata HR, Patterson LB, Sood VD, Kucherenko MM, Baker D, Ruohola-Baker H.
J Biol Chem. 2007 May 18; 20(282)15159-69
Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy.
Shcherbata HR, Yatsenko AS, Patterson L, Sood VD, Nudel U, Yaffe D, Baker D, Ruohola-Baker H.
EMBO J. 2007 Jan 24; 2(26)481-93
Stem cells signal to the niche through the Notch pathway in the Drosophila ovary.
Ward EJ, Shcherbata HR, Reynolds SH, Fischer KA, Hatfield SD, Ruohola-Baker H.
Curr Biol. 2006 Dec 5; 23(16)2352-8
Border of Notch activity establishes a boundary between the two dorsal appendage tube cell types.
Ward EJ, Zhou X, Riddiford LM, Berg CA, Ruohola-Baker H.
Dev Biol. 2006 Sep 15; 2(297)461-70
Jordan KC, Schaeffer V, Fischer KA, Gray EE, Ruohola-Baker H.
BMC Dev Biol. 2006 Mar 16; (6)16
The MicroRNA pathway plays a regulatory role in stem cell division.
Shcherbata HR, Hatfield S, Ward EJ, Reynolds S, Fischer KA, Ruohola-Baker H.
Cell Cycle. 2006 Jan; 2(5)172-5
Stem cell division is regulated by the microRNA pathway.
Hatfield SD, Shcherbata HR, Fischer KA, Nakahara K, Carthew RW, Ruohola-Baker H.
Nature. 2005 Jun 16; 7044(435)974-8
Althauser C, Jordan KC, Deng WM, Ruohola-Baker H.
Dev Dyn. 2005 Apr; 4(232)1013-20
Jordan KC, Hatfield SD, Tworoger M, Ward EJ, Fischer KA, Bowers S, Ruohola-Baker H.
Dev Dyn. 2005 Mar; 3(232)709-24
Shcherbata HR, Althauser C, Findley SD, Ruohola-Baker H.
Development. 2004 Jul; 13(131)3169-81
Schaeffer V, Althauser C, Shcherbata HR, Deng WM, Ruohola-Baker H.
Curr Biol. 2004 Apr 6; 7(14)630-6
Findley SD, Tamanaha M, Clegg NJ, Ruohola-Baker H.
Development. 2003 Mar; 5(130)859-71
Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila.
Deng WM, Schneider M, Frock R, Castillejo-Lopez C, Gaman EA, Baumgartner S, Ruohola-Baker H.
Development. 2003 Jan; 1(130)173-84
Deng WM, Althauser C, Ruohola-Baker H.
Development. 2001 Dec; 23(128)4737-46
Maelstrom is required to position the MTOC in stage 2-6 Drosophila oocytes.
Clegg NJ, Findley SD, Mahowald AP, Ruohola-Baker H.
Dev Genes Evol. 2001 Jan; 1(211)44-8
Role of Notch pathway in terminal follicle cell differentiation during Drosophila oogenesis.
Keller Larkin M, Deng WM, Holder K, Tworoger M, Clegg N, Ruohola-Baker H.
Dev Genes Evol. 1999 May; 5(209)301-11
Deng WM, Ruohola-Baker H.
Curr Biol. 2000 Jun 1; 11(10)683-6
Jordan KC, Clegg NJ, Blasi JA, Morimoto AM, Sen J, Stein D, McNeill H, Deng WM, Tworoger M, Ruohola-Baker H.
Nat Genet. 2000 Apr; 4(24)429-33
Bryant Z, Subrahmanyan L, Tworoger M, LaTray L, Liu CR, Li MJ, van den Engh G, Ruohola-Baker H.
Proc Natl Acad Sci U S A. 1999 May 11; 10(96)5559-64
Tworoger M, Larkin MK, Bryant Z, Ruohola-Baker H.
Genetics. 1999 Feb; 2(151)739-48
Clegg NJ, Frost DM, Larkin MK, Subrahmanyan L, Bryant Z, Ruohola-Baker H.
Development. 1997 Nov; 22(124)4661-71
Morimoto AM, Jordan KC, Tietze K, Britton JS, O'Neill EM, Ruohola-Baker H.
Development. 1996 Dec; 12(122)3745-54
Larkin MK, Holder K, Yost C, Giniger E, Ruohola-Baker H.
Development. 1996 Nov; 11(122)3639-50
Clark I, Giniger E, Ruohola-Baker H, Jan LY, Jan YN.
Curr Biol. 1994 Apr 1; 4(4)289-300
The role of gene cassettes in axis formation during Drosophila oogenesis.
Ruohola-Baker H, Jan LY, Jan YN.
Trends Genet. 1994 Mar; 3(10)89-94
Ruohola-Baker H, Grell E, Chou TB, Baker D, Jan LY, Jan YN.
Cell. 1993 Jun 4; 5(73)953-65
Research Summary
The Ruohola-Baker laboratory studies the molecules and cellular properties that are required for stem cell states and their differentiation capacity, both in normal and pathological situations. The key questions are (1) how do metabolic determinants of stem cells regulate epigenetics, (2) what are the key microRNAs controlling cellular maturation and (3) what is the molecular mechanism of stem cell protection against apoptosis.