University of Washington,
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Stem Cell Biology
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The Ruohola-Baker laboratory studies the molecules and cellular properties that are required for stem cell states and their differentiation capacity, both in normal and pathological situations. The key questions are (1) how do metabolic determinants of stem cells regulate epigenetics, (2) what are the key microRNAs controlling cellular maturation and (3) what is the molecular mechanism of stem cell protection against apoptosis.