faculty

Aakanksha Singhvi

asinghvi@fredhutch.org
Assistant Professor

Fred Hutch

Basic Sciences

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution

Neuroscience

Glia-Neuron Interactions

Faculty Contact Information

Building: Weintraub Room: A3-177 Box: A3-020 Phone: 206-667-3606

Research Summary

Molecular conversations between glia and neurons, the two major cells of our nervous system, are critical to all aspects of nervous system biology. However, while defects in glia-neuron interactions link to many neurological diseases, they remain largely enigmatic at molecular resolution.

Our lab aims to define molecular mechanisms of glia-neuron interactions in health, aging and disease models. For this, we deploy techniques at multiple focus levels, from molecular genetic, -omic, biochemical) to cell-biology (various microscopy) and animal behavior studies, as needed.

DEI Statement

I commit to give each trainee the support and guidance they need to achieve their full potential and goals. This includes listening and adapting to provide meaningfully tailored mentorship. Biases are neither binary nor limited to one issue or culture. I commit to being an advocate and ally, and for the lab to be a safe space for all. My commitment to an inclusive and egalitarian lab is deliberate. Our lab aims to grow and learn together, and consciously strive to do more and do better by each other.

Training Summary

Training
2020-2023 HHMI-Gilliam Faculty Mentorship Training
2021 Fred Hutch Bias Mitigation Education Training Module

Other Experiences
2018- Faculty Advisory Committee, Office on Diversity and
Inclusion, Fred Hutch
2015-2018 Strategic Planning Committee, The Rockefeller
University Diversity Initiative (represent all trainees)

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Publications

The following publications were retrieved from PubMed:

Charging Up the Periphery: Glial Ionic Regulation in Sensory Perception.

Ray S, Singhvi A.

Front Cell Dev Biol. 2021; (9)687732

Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior.

Raiders S, Black EC, Bae A, MacFarlane S, Klein M, Shaham S, Singhvi A.

Elife. 2021 Mar 24; (10)

Engulfed by Glia: Glial Pruning in Development, Function, and Injury across Species.

Raiders S, Han T, Scott-Hewitt N, Kucenas S, Lew D, Logan MA, Singhvi A.

J Neurosci. 2021 Feb 3; 5(41)823-833

A journey to 'tame a small metazoan organism', seen through the artistic eyes of C. elegans researchers.

Gourgou E, Willis AR, Giunti S, De Rosa MJ, Charlesworth AG, Hernandez Lima M, Glater E, Soo S, Pereira B, Akbaş K, Deb A, Kamak M, Moyle MW, Traa A, Singhvi A, Sural S, Jin EJ.

J Neurogenet. 2020 Sep-Dec; 3-4(34)549-560

Age-dependent changes in response property and morphology of a thermosensory neuron and thermotaxis behavior in Caenorhabditis elegans.

Huang TT, Matsuyama HJ, Tsukada Y, Singhvi A, Syu RT, Lu Y, Shaham S, Mori I, Pan CL.

Aging Cell. 2020 May; 5(19)e13146



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Lab Information

Location: Fred Hutchinson Cancer Research Center
Building: Weintraub
Room: A3-185
Box: A3-020
Phone: 206-667-7486
http://www.singhvilab.org/