faculty
Aakanksha Singhvi
asinghvi@fredhutch.org
Assistant Professor
Fred Hutch
,Basic Sciences
Cell Signaling & Cell/Environment Interactions
Genetics, Genomics & Evolution
Neuroscience
Glia-Neuron Interactions
Faculty Contact Information
Building: Weintraub
Room: A3-177
Box: A3-020
Phone: 206-667-3606
Research Summary
Molecular conversations between glia and neurons, the two major cells of our nervous system, are critical to all aspects of nervous system biology. However, while defects in glia-neuron interactions link to many neurological diseases, they remain largely enigmatic at molecular resolution.
Our lab aims to define molecular mechanisms of glia-neuron interactions in health, aging and disease models. For this, we deploy techniques at multiple focus levels, from molecular genetic, -omic, biochemical) to cell-biology (various microscopy) and animal behavior studies, as needed.
DEI Statement
Biases are neither binary nor limited to one issue or culture. My commitment to an inclusive and egalitarian lab is deliberate. I pledge to being a constant ally, advocate and listener, and for the lab to be a safe space for all. Our lab aims to grow and learn together as a team, and consciously strive to do more and do better by each other.
We are a team of diverse individuals that support, enable and take pride in each other. As a mentor, I aim to listen and adapt to provide meaningful, individually tailored mentor-ship. My goal is to to support and guide trainees to achieve their full potential and goals that they set for themselves & beyond. Every lab alumnus thus far has successfully transitioned into the career phase they had aspired for, including PhD, MD-PhD, and postdoctoral fellowship.
Training Summary
Training
Faculty Mentorship Training (HHMI-Gilliam) – 2020-2023
Bias Mitigation Education Training Module (Fred Hutch) – 2021
Other Experiences
Faculty Advisory Committee, Office on Diversity and Inclusion, Fred Hutch – 2018-Present
Strategic Planning Committee, The Rockefeller University Diversity Initiative (represent all trainees) – 2015-2018
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Publications
The following publications were retrieved from PubMed:
Editorial: Accessory Cells of Sensory Systems and Their Functional Roles.
Ackerman SD, Singhvi A, Bianchi L.
Front Neurosci. 2022; (16)965580
Multiplexing Thermotaxis Behavior Measurement in Caenorhabditis elegans.
Raiders S, Klein M, Singhvi A.
Bio Protoc. 2022 Apr 5; 7(12)e4370
Charging Up the Periphery: Glial Ionic Regulation in Sensory Perception.
Ray S, Singhvi A.
Front Cell Dev Biol. 2021; (9)687732
Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior.
Raiders S, Black EC, Bae A, MacFarlane S, Klein M, Shaham S, Singhvi A.
Elife. 2021 Mar 24; (10)
Engulfed by Glia: Glial Pruning in Development, Function, and Injury across Species.
Raiders S, Han T, Scott-Hewitt N, Kucenas S, Lew D, Logan MA, Singhvi A.
J Neurosci. 2021 Feb 3; 5(41)823-833
Gourgou E, Willis AR, Giunti S, De Rosa MJ, Charlesworth AG, Hernandez Lima M, Glater E, Soo S, Pereira B, Akbaş K, Deb A, Kamak M, Moyle MW, Traa A, Singhvi A, Sural S, Jin EJ.
J Neurogenet. 2020 Sep-Dec; 3-4(34)549-560
Huang TT, Matsuyama HJ, Tsukada Y, Singhvi A, Syu RT, Lu Y, Shaham S, Mori I, Pan CL.
Aging Cell. 2020 May; 5(19)e13146
Glia-Neuron Interactions in Caenorhabditis elegans.
Singhvi A, Shaham S.
Annu Rev Neurosci. 2019 Jul 8; (42)149-168
Wallace SW, Singhvi A, Liang Y, Lu Y, Shaham S.
Cell Rep. 2016 Apr 19; 3(15)550-562
A Glial K/Cl Transporter Controls Neuronal Receptive Ending Shape by Chloride Inhibition of an rGC.
Singhvi A, Liu B, Friedman CJ, Fong J, Lu Y, Huang XY, Shaham S.
Cell. 2016 May 5; 4(165)936-48
Teuliere J, Cordes S, Singhvi A, Talavera K, Garriga G.
Genetics. 2014 Sep; 1(198)229-47
The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions.
Singhvi A, Teuliere J, Talavera K, Cordes S, Ou G, Vale RD, Prasad BC, Clark SG, Garriga G.
Curr Biol. 2011 Jun 7; 11(21)948-54
Building a sustainable career in science.
Singhvi A, Sachdev P.
Nat Biotechnol. 2010 Apr; 4(28)378-9
Asymmetric divisions, aggresomes and apoptosis.
Singhvi A, Garriga G.
Trends Cell Biol. 2009 Jan; 1(19)1-7
Singhvi A, Frank CA, Garriga G.
Genetics. 2008 Jun; 2(179)887-98
Taste representations in the Drosophila brain.
Wang Z, Singhvi A, Kong P, Scott K.
Cell. 2004 Jun 25; 7(117)981-91
PubMed Collection Link
Accepting Students For:
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Permanent
Lab Information
Location: Fred Hutchinson Cancer Research Center
Building: Weintraub
Room: A3-185
Box: A3-020
Phone: 206-667-7486
http://www.singhvilab.org/
Building: Weintraub
Room: A3-185
Box: A3-020
Phone: 206-667-7486
http://www.singhvilab.org/