faculty
Aakanksha Singhvi
asinghvi@fredhutch.org
Assistant Professor
Fred Hutch
,Basic Sciences
Cell Signaling & Cell/Environment Interactions
Neuroscience
Glia-Neuron Interactions
Faculty Contact Information
Building: Weintraub
Room: A3-177
Box: A3-020
Phone: 206-667-3606
Research Summary
Our nervous system has two major cell types, neurons and glia, in about equal numbers. These two cell types communicate extensively with each other, which is critical for proper nervous system function. Disrupted interactions between these two cell types underlie many neurological disorders of development, function (sensory or cognitive impairments) and aging.
Our lab is interested in building a molecular framework of how glia and neurons communicate with each other to regulate sensory perception, neuronal physiology, neural circuit activity, memory formation and animal behavior.
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Publications
The following publications were retrieved from PubMed:
Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior.
Raiders S, Black EC, Bae A, MacFarlane S, Klein M, Shaham S, Singhvi A.
Elife. 2021 Mar 24; (10)
Engulfed by Glia: Glial Pruning in Development, Function, and Injury across Species.
Raiders S, Han T, Scott-Hewitt N, Kucenas S, Lew D, Logan MA, Singhvi A.
J Neurosci. 2021 Feb 3; 5(41)823-833
Gourgou E, Willis AR, Giunti S, De Rosa MJ, Charlesworth AG, Hernandez Lima M, Glater E, Soo S, Pereira B, Akbaş K, Deb A, Kamak M, Moyle MW, Traa A, Singhvi A, Sural S, Jin EJ.
J Neurogenet. 2020 Sep-Dec; 3-4(34)549-560
Huang TT, Matsuyama HJ, Tsukada Y, Singhvi A, Syu RT, Lu Y, Shaham S, Mori I, Pan CL.
Aging Cell. 2020 May; 5(19)e13146
Glia-Neuron Interactions in Caenorhabditis elegans.
Singhvi A, Shaham S.
Annu Rev Neurosci. 2019 Jul 8; (42)149-168
Wallace SW, Singhvi A, Liang Y, Lu Y, Shaham S.
Cell Rep. 2016 Apr 19; 3(15)550-562
A Glial K/Cl Transporter Controls Neuronal Receptive Ending Shape by Chloride Inhibition of an rGC.
Singhvi A, Liu B, Friedman CJ, Fong J, Lu Y, Huang XY, Shaham S.
Cell. 2016 May 5; 4(165)936-48
Teuliere J, Cordes S, Singhvi A, Talavera K, Garriga G.
Genetics. 2014 Sep; 1(198)229-47
The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions.
Singhvi A, Teuliere J, Talavera K, Cordes S, Ou G, Vale RD, Prasad BC, Clark SG, Garriga G.
Curr Biol. 2011 Jun 7; 11(21)948-54
Building a sustainable career in science.
Singhvi A, Sachdev P.
Nat Biotechnol. 2010 Apr; 4(28)378-9
Asymmetric divisions, aggresomes and apoptosis.
Singhvi A, Garriga G.
Trends Cell Biol. 2009 Jan; 1(19)1-7
Singhvi A, Frank CA, Garriga G.
Genetics. 2008 Jun; 2(179)887-98
Taste representations in the Drosophila brain.
Wang Z, Singhvi A, Kong P, Scott K.
Cell. 2004 Jun 25; 7(117)981-91
PubMed Collection Link
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Permanent
Lab Information
Location: Fred Hutchinson Cancer Research Center
Building: Weintraub
Room: A3-185
Box: A3-020
Phone: 206-667-7486
http://www.singhvilab.org/
Building: Weintraub
Room: A3-185
Box: A3-020
Phone: 206-667-7486
http://www.singhvilab.org/