faculty

Aakanksha Singhvi

asinghvi@fredhutch.org
Assistant Member

Fred Hutch

Basic Sciences

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution

Neuroscience

Glia-Neuron Interactions

Faculty Contact Information

Building: Weintraub Room: A3-177 Box: A3-020 Phone: 206-667-3606

Research Summary

Our nervous system has two major cell types, neurons and glia, in about equal numbers. These two cell types communicate extensively with each other, which is critical for proper nervous system function. Disrupted interactions between these two cell types underlie many neurological disorders of development, function (sensory or cognitive impairments) and aging.

Our lab is interested in building a molecular framework of how glia and neurons communicate with each other to regulate sensory perception, neuronal physiology, neural circuit activity, memory formation and animal behavior.

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Publications

The following publications were retrieved from PubMed:

Glia-Neuron Interactions in <i>Caenorhabditis elegans</i>.

Singhvi A, Shaham S.

Annu Rev Neurosci. 2019 Jul 8; (42)149-168

PROS-1/Prospero Is a Major Regulator of the Glia-Specific Secretome Controlling Sensory-Neuron Shape and Function in C. elegans.

Wallace SW, Singhvi A, Liang Y, Lu Y, Shaham S.

Cell Rep. 2016 Apr 19; 3(15)550-562

A Glial K/Cl Transporter Controls Neuronal Receptive Ending Shape by Chloride Inhibition of an rGC.

Singhvi A, Liu B, Friedman CJ, Fong J, Lu Y, Huang XY, Shaham S.

Cell. 2016 May 5; 4(165)936-48

Asymmetric neuroblast divisions producing apoptotic cells require the cytohesin GRP-1 in Caenorhabditis elegans.

Teuliere J, Cordes S, Singhvi A, Talavera K, Garriga G.

Genetics. 2014 Sep; 1(198)229-47

The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions.

Singhvi A, Teuliere J, Talavera K, Cordes S, Ou G, Vale RD, Prasad BC, Clark SG, Garriga G.

Curr Biol. 2011 Jun 7; 11(21)948-54

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Lab Information

Location: Fred Hutchinson Cancer Research Center
Building: Weintraub
Room: A3-185
Box: A3-020
Phone: 206-667-7486
http://www.singhvilab.org/