faculty
Aakanksha Singhvi
asinghvi@fredhutch.org
Assistant Professor
Fred Hutch
,Basic Sciences
Cell Signaling & Cell/Environment Interactions
Genetics, Genomics & Evolution
Neuroscience
Glia-Neuron Interactions
Faculty Contact Information
Building: Weintraub
Room: A3-177
Box: A3-020
Phone: 206-667-3606
Research Summary
Molecular conversations between glia and neurons, the two major cells of our nervous system, are critical to all aspects of nervous system biology. However, while defects in glia-neuron interactions link to many neurological diseases, they remain largely enigmatic at molecular resolution.
Our lab aims to define molecular mechanisms of glia-neuron interactions in health, aging and disease models. For this, we deploy techniques at multiple focus levels, from molecular genetic, -omic, biochemical) to cell-biology (various microscopy) and animal behavior studies, as needed.
DEI Statement
I commit to give each trainee the support and guidance they need to achieve their full potential and goals. This includes listening and adapting to provide meaningfully tailored mentorship. Biases are neither binary nor limited to one issue or culture. I commit to being an advocate and ally, and for the lab to be a safe space for all. My commitment to an inclusive and egalitarian lab is deliberate. Our lab aims to grow and learn together, and consciously strive to do more and do better by each other.
Training Summary
Training
2020-2023 HHMI-Gilliam Faculty Mentorship Training
2021 Fred Hutch Bias Mitigation Education Training Module
Other Experiences
2018- Faculty Advisory Committee, Office on Diversity and
Inclusion, Fred Hutch
2015-2018 Strategic Planning Committee, The Rockefeller
University Diversity Initiative (represent all trainees)
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Publications
The following publications were retrieved from PubMed:
Multiplexing Thermotaxis Behavior Measurement in Caenorhabditis elegans.
Raiders S, Klein M, Singhvi A.
Bio Protoc. 2022 Apr 5; 7(12)e4370
Charging Up the Periphery: Glial Ionic Regulation in Sensory Perception.
Ray S, Singhvi A.
Front Cell Dev Biol. 2021; (9)687732
Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior.
Raiders S, Black EC, Bae A, MacFarlane S, Klein M, Shaham S, Singhvi A.
Elife. 2021 Mar 24; (10)
Engulfed by Glia: Glial Pruning in Development, Function, and Injury across Species.
Raiders S, Han T, Scott-Hewitt N, Kucenas S, Lew D, Logan MA, Singhvi A.
J Neurosci. 2021 Feb 3; 5(41)823-833
Gourgou E, Willis AR, Giunti S, De Rosa MJ, Charlesworth AG, Hernandez Lima M, Glater E, Soo S, Pereira B, Akbaş K, Deb A, Kamak M, Moyle MW, Traa A, Singhvi A, Sural S, Jin EJ.
J Neurogenet. 2020 Sep-Dec; 3-4(34)549-560
Huang TT, Matsuyama HJ, Tsukada Y, Singhvi A, Syu RT, Lu Y, Shaham S, Mori I, Pan CL.
Aging Cell. 2020 May; 5(19)e13146
Glia-Neuron Interactions in Caenorhabditis elegans.
Singhvi A, Shaham S.
Annu Rev Neurosci. 2019 Jul 8; (42)149-168
Wallace SW, Singhvi A, Liang Y, Lu Y, Shaham S.
Cell Rep. 2016 Apr 19; 3(15)550-562
A Glial K/Cl Transporter Controls Neuronal Receptive Ending Shape by Chloride Inhibition of an rGC.
Singhvi A, Liu B, Friedman CJ, Fong J, Lu Y, Huang XY, Shaham S.
Cell. 2016 May 5; 4(165)936-48
Teuliere J, Cordes S, Singhvi A, Talavera K, Garriga G.
Genetics. 2014 Sep; 1(198)229-47
The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions.
Singhvi A, Teuliere J, Talavera K, Cordes S, Ou G, Vale RD, Prasad BC, Clark SG, Garriga G.
Curr Biol. 2011 Jun 7; 11(21)948-54
Building a sustainable career in science.
Singhvi A, Sachdev P.
Nat Biotechnol. 2010 Apr; 4(28)378-9
Asymmetric divisions, aggresomes and apoptosis.
Singhvi A, Garriga G.
Trends Cell Biol. 2009 Jan; 1(19)1-7
Singhvi A, Frank CA, Garriga G.
Genetics. 2008 Jun; 2(179)887-98
Taste representations in the Drosophila brain.
Wang Z, Singhvi A, Kong P, Scott K.
Cell. 2004 Jun 25; 7(117)981-91
PubMed Collection Link
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Permanent
Lab Information
Location: Fred Hutchinson Cancer Research Center
Building: Weintraub
Room: A3-185
Box: A3-020
Phone: 206-667-7486
http://www.singhvilab.org/
Building: Weintraub
Room: A3-185
Box: A3-020
Phone: 206-667-7486
http://www.singhvilab.org/