faculty

Yasemin Sancak

sancak@uw.edu

University of Washington, 

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Mitochondrial signaling

Faculty Contact Information

Building: Health Sciences Building K wing Room: K 536B https://sites.uw.edu/sancaklb/

Lab Information

Location: University of Washington Building: Health Sciences Building K Wing Room: K 526

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+.

Kamer KJ, Sancak Y, Fomina Y, Meisel JD, Chaudhuri D, Grabarek Z, Mootha VK.

Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(34):E7960-E7969.

PubMed [journal]
PMID:
30082385
PMCID:
PMC6112746

A Protective Role for Triacylglycerols during Apoptosis.

Li N, Sancak Y, Frasor J, Atilla-Gokcumen GE.

Biochemistry. 2018; 57(1):72-80. NIHMSID: NIHMS968213

PubMed [journal]
PMID:
29188717
PMCID:
PMC5975242

Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter.

Bick AG, Wakimoto H, Kamer KJ, Sancak Y, Goldberger O, Axelsson A, DeLaughter DM, Gorham JM, Mootha VK, Seidman JG, Seidman CE.

Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(43):E9096-E9104.

PubMed [journal]
PMID:
29073106
PMCID:
PMC5664535

Architecture of the mitochondrial calcium uniporter.

Oxenoid K, Dong Y, Cao C, Cui T, Sancak Y, Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, Cong Y, Mootha VK, Chou JJ.

Nature. 2016; 533(7602):269-73. NIHMSID: NIHMS767129

PubMed [journal]
PMID:
27135929
PMCID:
PMC4874835

The uniporter: from newly identified parts to function.

Kamer KJ, Sancak Y, Mootha VK.

Biochemical and biophysical research communications. 2014; 449(4):370-2.

PubMed [journal]
PMID:
24814702

Research Summary

Mitochondria are fascinating organelles that coordinate cellular metabolism, generate ATP, function in protein quality control and regulate calcium signaling. Our laboratory is interested in understanding how mitochondria communicate with the rest of the cell to answer cellular needs, and how these communication pathways are altered in disease.