Yasemin Sancak
sancak@uw.eduUniversity of Washington,
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Mitochondrial signaling
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+.
Kamer KJ, Sancak Y, Fomina Y, Meisel JD, Chaudhuri D, Grabarek Z, Mootha VK.
Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(34):E7960-E7969.
- PMID:
- 30082385
- PMCID:
- PMC6112746
A Protective Role for Triacylglycerols during Apoptosis.
Li N, Sancak Y, Frasor J, Atilla-Gokcumen GE.
Biochemistry. 2018; 57(1):72-80. NIHMSID: NIHMS968213
- PMID:
- 29188717
- PMCID:
- PMC5975242
Bick AG, Wakimoto H, Kamer KJ, Sancak Y, Goldberger O, Axelsson A, DeLaughter DM, Gorham JM, Mootha VK, Seidman JG, Seidman CE.
Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(43):E9096-E9104.
- PMID:
- 29073106
- PMCID:
- PMC5664535
Architecture of the mitochondrial calcium uniporter.
Oxenoid K, Dong Y, Cao C, Cui T, Sancak Y, Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, Cong Y, Mootha VK, Chou JJ.
Nature. 2016; 533(7602):269-73. NIHMSID: NIHMS767129
- PMID:
- 27135929
- PMCID:
- PMC4874835
The uniporter: from newly identified parts to function.
Kamer KJ, Sancak Y, Mootha VK.
Biochemical and biophysical research communications. 2014; 449(4):370-2.
- PMID:
- 24814702
Reconstitution of the mitochondrial calcium uniporter in yeast.
Kovács-Bogdán E, Sancak Y, Kamer KJ, Plovanich M, Jambhekar A, Huber RJ, Myre MA, Blower MD, Mootha VK.
Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(24):8985-90.
- PMID:
- 24889638
- PMCID:
- PMC4066498
EMRE is an essential component of the mitochondrial calcium uniporter complex.
Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK.
Science (New York, N.Y.). 2013; 342(6164):1379-82. NIHMSID: NIHMS596317
- PMID:
- 24231807
- PMCID:
- PMC4091629
MCU encodes the pore conducting mitochondrial calcium currents.
Chaudhuri D, Sancak Y, Mootha VK, Clapham DE.
eLife. 2013; 2:e00704.
- PMID:
- 23755363
- PMCID:
- PMC3673318
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.
Csordás G, Golenár T, Seifert EL, Kamer KJ, Sancak Y, Perocchi F, Moffat C, Weaver D, de la Fuente Perez S, Bogorad R, Koteliansky V, Adijanto J, Mootha VK, Hajnóczky G.
Cell metabolism. 2013; 17(6):976-87. NIHMSID: NIHMS479782
- PMID:
- 23747253
- PMCID:
- PMC3722067
Plovanich M, Bogorad RL, Sancak Y, Kamer KJ, Strittmatter L, Li AA, Girgis HS, Kuchimanchi S, De Groot J, Speciner L, Taneja N, Oshea J, Koteliansky V, Mootha VK.
PloS one. 2013; 8(2):e55785.
- PMID:
- 23409044
- PMCID:
- PMC3567112
Research Summary
Mitochondria are fascinating organelles that coordinate cellular metabolism, generate ATP, function in protein quality control and regulate calcium signaling. Our laboratory is interested in understanding how mitochondria communicate with the rest of the cell to answer cellular needs, and how these communication pathways are altered in disease.