faculty

Kelley Harris

harriske@uw.edu
Assistant Professor

University of Washington

Computational Biology

Genetics, Genomics & Evolution

Population genetics and mutation rate evolution

Faculty Contact Information

Box: Foege 420

Research Summary

I use population genetic theory and high-throughput biological sequence analysis to study recent evolutionary history in humans and other species. One of my primary research interests is the evolution of mutagenesis–I want to understand the forces that control DNA replication fidelity, the mutational breakdown of established traits, and the ultimate origin of new traits. We are particularly interested in deciphering which evolutionary pressures (such as cancer, congenital disease, or life history) might be driving mutation rates and spectra to change over time.

DEI Statement

As a population geneticist, I work in a field whose origins have very problematic ties to eugenics and white supremacy. At the same time, population genetics is now an essential tool we will need to deliver equitable health care to people whose genetic backgrounds are not well represented by the European reference panels that have dominated most human genetics research. In my group, we try to have nuanced discussions of these issues and regularly examine how our work has the potential to impact society both positively and negatively.

Training Summary

2020: University of Minnesota online training on Optimizing the Practice of Mentoring: discussed strategies for facilitating mentoring and for overcoming challenges

2020: University of Wisconsin CIMER training on Culturally Aware Mentoring: explored how awareness of cultural heritage can improve mentoring

2021: Lavender Rights Project training aimed at making genomics inclusive for marginalized populations.

2021: CIMER Training on Mentoring Up

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_62bd0751e768773256152d27&retmode=json
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Publications

The following publications were retrieved from PubMed:

A natural mutator allele shapes mutation spectrum variation in mice.

Sasani TA, Ashbrook DG, Beichman AC, Lu L, Palmer AA, Williams RW, Pritchard JK, Harris K.

Nature. 2022 May; 7910(605)497-502

Resilience integrates concepts in aging research.

Promislow D, Anderson RM, Scheffer M, Crespi B, DeGregori J, Harris K, Horowitz BN, Levine ME, Riolo MA, Schneider DS, Spencer SL, Valenzano DR, Hochberg ME.

iScience. 2022 May 20; 5(25)104199

The apportionment of citations: a scientometric analysis of Lewontin 1972.

Carlson J, Harris K.

Philos Trans R Soc Lond B Biol Sci. 2022 Jun 6; 1852(377)20200409

The Mutationathon highlights the importance of reaching standardization in estimates of pedigree-based germline mutation rates.

Bergeron LA, Besenbacher S, Turner T, Versoza CJ, Wang RJ, Price AL, Armstrong E, Riera M, Carlson J, Chen HY, Hahn MW, Harris K, Kleppe AS, López-Nandam EH, Moorjani P, Pfeifer SP, Tiley GP, Yoder AD, Zhang G, Schierup MH.

Elife. 2022 Jan 12; (11)

Accepting Students For:

Rotation, Autumn
Permanent

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