faculty
Armita Nourmohammad
armita@uw.edu
Assistant Professor
University of Washington
Biophysical and Structural Biology
Computational Biology
Microbiology, Infection & Immunity
theoretical and computational approaches to evolution and immunology
Faculty Contact Information
Research Summary
We are broadly interested in questions at the interface of statistical physics and biology, and we address them be developing theoretical models and statistical inference from molecular data. A current interest of our group is the adaptive immune system: We aim to understand the principles underlying the organization and encoding of information in the adaptive immune system, in light of host-pathogen coevolution.
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Publications
The following publications were retrieved from PubMed:
Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1.
LaMont C, Otwinowski J, Vanshylla K, Gruell H, Klein F, Nourmohammad A.
Elife. 2022 Jul 19; (11)
Isacchini G, Spisak N, Nourmohammad A, Mora T, Walczak AM.
Phys Rev E. 2022 May; 5-2(105)055309
Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing.
Wang Y, Lei R, Nourmohammad A, Wu NC.
Elife. 2021 Dec 8; (10)
Montague Z, Lv H, Otwinowski J, DeWitt WS, Isacchini G, Yip GK, Ng WW, Tsang OT, Yuan M, Liu H, Wilson IA, Peiris JSM, Wu NC, Nourmohammad A, Mok CKP.
Cell Rep. 2021 May 25; 8(35)109173
Optimal evolutionary decision-making to store immune memory.
Schnaack OH, Nourmohammad A.
Elife. 2021 Apr 28; (10)
Deep generative selection models of T and B cell receptor repertoires with soNNia.
Isacchini G, Walczak AM, Mora T, Nourmohammad A.
Proc Natl Acad Sci U S A. 2021 Apr 6; 14(118)
Information-Geometric Optimization with Natural Selection.
Otwinowski J, LaMont CH, Nourmohammad A.
Entropy (Basel). 2020 Aug 31; 9(22)
SOS: online probability estimation and generation of T-and B-cell receptors.
Isacchini G, Olivares C, Nourmohammad A, Walczak AM, Mora T.
Bioinformatics. 2020 Aug 15; 16(36)4510-4512
Montague Z, Lv H, Otwinowski J, DeWitt WS, Isacchini G, Yip GK, Ng WW, Tsang OT, Yuan M, Liu H, Wilson IA, Peiris JSM, Wu NC, Nourmohammad A, Mok CKP.
medRxiv. 2021 Apr 5;
Montague Z, Lv H, Otwinowski J, DeWitt WS, Isacchini G, Yip GK, Ng WW, Tsang OT, Yuan M, Liu H, Wilson IA, Peiris JSM, Wu NC, Nourmohammad A, Mok CKP.
ArXiv. 2020 Jul 14;
Generative models of T-cell receptor sequences.
Isacchini G, Sethna Z, Elhanati Y, Nourmohammad A, Walczak AM, Mora T.
Phys Rev E. 2020 Jun; 6-1(101)062414
Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape.
Wu NC, Otwinowski J, Thompson AJ, Nycholat CM, Nourmohammad A, Wilson IA.
Nat Commun. 2020 Mar 6; 1(11)1233
The size of the immune repertoire of bacteria.
Bradde S, Nourmohammad A, Goyal S, Balasubramanian V.
Proc Natl Acad Sci U S A. 2020 Mar 10; 10(117)5144-5151
Fierce Selection and Interference in B-Cell Repertoire Response to Chronic HIV-1.
Nourmohammad A, Otwinowski J, Łuksza M, Mora T, Walczak AM.
Mol Biol Evol. 2019 Oct 1; 10(36)2184-2194
Gene expression variability across cells and species shapes innate immunity.
Hagai T, Chen X, Miragaia RJ, Rostom R, Gomes T, Kunowska N, Henriksson J, Park JE, Proserpio V, Donati G, Bossini-Castillo L, Vieira Braga FA, Naamati G, Fletcher J, Stephenson E, Vegh P, Trynka G, Kondova I, Dennis M, Haniffa M, Nourmohammad A, Lässig M, Teichmann SA.
Nature. 2018 Nov; 7730(563)197-202
Adaptive Evolution of Gene Expression in Drosophila.
Nourmohammad A, Rambeau J, Held T, Kovacova V, Berg J, Lässig M.
Cell Rep. 2017 Aug 8; 6(20)1385-1395
Nourmohammad A, Otwinowski J, Plotkin JB.
PLoS Genet. 2016 Jul; 7(12)e1006171
Universality and predictability in molecular quantitative genetics.
Nourmohammad A, Held T, Lässig M.
Curr Opin Genet Dev. 2013 Dec; 6(23)684-93
Formation of regulatory modules by local sequence duplication.
Nourmohammad A, Lässig M.
PLoS Comput Biol. 2011 Oct; 10(7)e1002167
Abdolvahab RH, Roshani F, Nourmohammad A, Sahimi M, Tabar MR.
J Chem Phys. 2008 Dec 21; 23(129)235102
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Lab Information
Location: Department of Physics, University of Washington
Building: PAB
Building: PAB