Bernard Khor

Assistant Member

Benaroya Research Institute

Cell Signaling & Cell/Environment Interactions

Computational Biology

Developmental Biology, Stem Cells & Aging

Gene Expression, Cell Cycle & Chromosome Biology

Microbiology, Infection & Immunity

Novel pathways of immune aging and autoimmunity in people with Down syndrome

Faculty Contact Information

Building: Benaroya Research Institute Room: 270 Box: IN-RC Phone: 206-341-8900

Research Summary

We are interested in understanding novel pathways that regulate tolerance, how these are dysregulated in autoimmunity, and what therapies may restore immune homeostasis. We take a multidisciplinary approach that brings together genetics, chemistry, computational and clinical collaborators to highlight disease-relevant biology. A major interest of the lab is understanding the mechanistic basis of immune dysregulation in people with Down syndrome, and leveraging these efforts to identify novel therapies that may benefit both people with Down syndrome as well as people with other immune disorders. In example, recent work by the lab demonstrates advanced immune aging and an autoimmunity-poised state in people with Down syndrome. Understanding the underlying mechanistic drivers will enable precision therapies for people with and without Down syndrome.

DEI Statement

As an immigrant from Singapore, a person with hemophilia, a first-generation college graduate, and a trainee of top 10 institutions, I have experienced bias and privilege. I have learned firsthand the tremendous value and power of mentors that encouraged and helped me at every stage of my career. In my lab I strive to pay it forward by recruiting talent from underrepresented backgrounds and training them towards their top career goals in an environment that is supportive and values the journey and success of all.

Resource id #313 -- NULL

PubMed Collection Link

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter

Lab Information

Location: Benaroya Research Institute
Building: Benaroya Research Institute
Room: 270
Box: 270
Phone: 206-341-8900