Benaroya Research Institute
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Gene Expression, Cell Cycle & Chromosome Biology
Microbiology, Infection & Immunity
Novel pathways of immune aging and autoimmunity in people with Down syndrome
Faculty Contact Information
We are interested in understanding novel pathways that regulate tolerance, how these are dysregulated in autoimmunity, and what therapies may restore immune homeostasis. We take a multidisciplinary approach that brings together genetics, chemistry, computational and clinical collaborators to highlight disease-relevant biology. A major interest of the lab is understanding the mechanistic basis of immune dysregulation in people with Down syndrome, and leveraging these efforts to identify novel therapies that may benefit both people with Down syndrome as well as people with other immune disorders. In example, recent work by the lab demonstrates advanced immune aging and an autoimmunity-poised state in people with Down syndrome. Understanding the underlying mechanistic drivers will enable precision therapies for people with and without Down syndrome.
As an immigrant from Singapore, a person with hemophilia, a first-generation college graduate, and a trainee of top 10 institutions, I have experienced bias and privilege. I have learned firsthand the tremendous value and power of mentors that encouraged and helped me at every stage of my career. In my lab I strive to pay it forward by recruiting talent from underrepresented backgrounds and training them towards their top career goals in an environment that is supportive and values the journey and success of all.
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Building: Benaroya Research Institute