faculty

Liangcai Gu

gulc@uw.edu

University of Washington, 

Biophysical and Structural Biology

Microbiology, Infection & Immunity

Protein interaction profiling and engineering using in situ sequencing technologies

Faculty Contact Information

Building: HSB Room: J583 Box: UW Box 357350 Phone: 206-221-0382 Alt Phone: 206-221-7730 http://interactomelab.org/

Lab Information

Location: University of Washington Building: HSB Room: J579 Phone: 206-221-7730 http://interactomelab.org/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Winter
Permanent

Research Summary

We use quantitative protein interaction profiling to understand molecular recognition and guide computational protein design. We develop protein interaction sequencing technologies by coupling protein barcoding and in situ sequencing techniques to measure single-molecule proteins and complexes in massively parallel. Our current research is focused in three major areas: (1) engineering of ligand-responsive protein assemblies, (2) human protein interactome profiling and drug screening, and (3) functional profiling of antigen receptors.