faculty

Liangcai Gu

gulc@uw.edu

Assistant Professor

University of Washington

Biochemistry

Biophysical and Structural Biology

Microbiology, Infection & Immunity

Protein interaction profiling and engineering using in situ sequencing technologies

Faculty Contact Information

Building: HSB Room: J583 Box: UW Box 357350 Phone: 206-221-0382 Alt Phone: 206-221-7730 http://interactomelab.org/

Research Summary

We use quantitative protein interaction profiling to understand molecular recognition and guide computational protein design. We develop protein interaction sequencing technologies by coupling protein barcoding and in situ sequencing techniques to measure single-molecule proteins and complexes in massively parallel. Our current research is focused in three major areas: (1) engineering of ligand-responsive protein assemblies, (2) human protein interactome profiling and drug screening, and (3) functional profiling of antigen receptors.

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Publications

The following publications were retrieved from PubMed:

Creating Red Light-Switchable Protein Dimerization Systems as Genetically Encoded Actuators with High Specificity.

Huang Z, Li Z, Zhang X, Kang S, Dong R, Sun L, Fu X, Vaisar D, Watanabe K, Gu L.

ACS Synth Biol. 2020 Dec 18; 12(9)3322-3333

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library.

Gomez-Castillo L, Watanabe K, Jiang H, Kang S, Gu L.

J Vis Exp. 2020 Jan 14; 155

COMBINES-CID: An Efficient Method for De Novo Engineering of Highly Specific Chemically Induced Protein Dimerization Systems.

Kang S, Davidsen K, Gomez-Castillo L, Jiang H, Fu X, Li Z, Liang Y, Jahn M, Moussa M, DiMaio F, Gu L.

J Am Chem Soc. 2019 Jul 17; 28(141)10948-10952

Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase.

Khare D, Hale WA, Tripathi A, Gu L, Sherman DH, Gerwick WH, Håkansson K, Smith JL.

Structure. 2015 Dec 1; 12(23)2213-2223

Multiplex single-molecule interaction profiling of DNA-barcoded proteins.

Gu L, Li C, Aach J, Hill DE, Vidal M, Church GM.

Nature. 2014 Nov 27; 7528(515)554-7

Accepting Students For:

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Lab Information

Location: University of Washington
Building: HSB
Room: J579
Phone: 206-221-7730
http://interactomelab.org/