Developmental Biology, Stem Cells & Aging
Epigenomic Regulation of Development and Regeneration in the Mammalian Retina
Mammalian regeneration in the retina after disease-associated cell loss is minimal to nonexistant. By overexpressing the neurogeneic transcription factor Ascl1 in the Müller Glia, some cell fate change and neronal regeneration can occur but is limited in neuron types and is restricted to young retinas. I hope to discover the epigenetic role in reprogramming repression and in development in general, specifically as related to novel histone repressors.